Results 101 to 110 of about 76,259 (245)

Chronic Lymphocytic Leukemia and other Chronic Lymphoid Leukemias

DeckerMed Medicine, 2017
The chronic lymphoid leukemias are a group of generally indolent B cell malignancies that include chronic lymphocytic leukemia (CLL), prolymphocytic leukemia, hairy cell leukemia, and large granular lymphocyte leukemia. The unique aspects of diagnosis and management for each condition are discussed separately, with the primary focus being on CLL, the ...
openaire   +1 more source

Efficacy and Safety of the Third‐Generation Tyrosine Kinase Inhibitor Olverembatinib in Combination With Inotuzumab Ozogamicin for the Treatment of Adult Philadelphia Chromosome‐Positive Acute Lymphoblastic Leukemia Patients With Refractory/Relapsed Disease or Persistent Minimal Residual Disease Bridging to Hematopoietic Stem Cell Transplantation

American Journal of Hematology, EarlyView.
Xiaoyu Zhang, Yigeng Cao, Jialin Wei, Weihua Zhai, Qiaoling Ma, Chen Liang, Xin Chen, Wenbin Cao, Donglin Yang, Aiming Pang, Yi He, Sizhou Feng, Mingzhe Han, Rongli Zhang, Erlie Jiang   +14 more
wiley   +1 more source

RORγt‐APCs: The New Masters of Oral Tolerance

Barrier Immunity, EarlyView.
ABSTRACT Oral tolerance is defined by the hypo‐responsiveness of our body to fed antigens, and its failure can lead to immune‐mediated diseases, such as allergy, chronic inflammation and autoimmune diseases. Decades of research have demonstrated that antigen‐presenting cells (APCs) promote oral tolerance by inducing regulatory T cells (Tregs) and/or ...
Thierry Gauthier, WanJun Chen
wiley   +1 more source

Expert Perspective: Hematologic Malignancies and Vasculitis

Arthritis &Rheumatology, EarlyView.
Michelle L. Robinette, Hetty E. Carraway
wiley   +1 more source

The Nutritional and Bioactive Components, Potential Health Function and Comprehensive Utilization of Hawthorn: A Review

Food Frontiers, EarlyView.
This review systematically and comprehensively analyzes hawthorn (Crataegus spp.), covering its bioactive constituents, properties, and processed products. ABSTRACT Hawthorn is widely cultivated in China, with excellent varieties and steadily increasing production.
Wenteng Yang, Quanhong Gao, Kun Ran, Mingyue Jiao, Xiaodan Fu, Zhenlin Han, Chao Liu, Ningyang Li   +7 more
wiley   +1 more source

Lineage assignment role of immunophenotyping in acute leukemia

Journal of Associated Medical Sciences, 2012
Objective: To assess the role of routine multiparameter flow cytometry, for lineage assignment of leukemic cells in patients with acute leukemia. Materials and Methods: One hundred cases of adult and children patients diagnosed with acute leukemia ...
Nopporn Juengpichanvanich, Charin Ya-in, Lertlakana Bhoopat, Lalita Norasetthada   +3 more
doaj  

Precursor B Cell Acute Lymphoblastic Leukemia Presenting with Repeated Episodes of Hemophagocytic Lymphohistiocytosis

Indian Journal of Medical and Paediatric Oncology
Hemophagocytic lymphohistiocytosis (HLH) is a rare disorder characterized by dysregulated activation of cytotoxic T-lymphocytes and macrophages, resulting in excessive cytokine release and tissue damage.
Nihar Desai, Dinesh Chandra, Ruchi Gupta, Rajesh Kashyap   +3 more
doaj   +1 more source

Mechanisms of enhancer‐driven oncogene activation

International Journal of Cancer, EarlyView.
Abstract An aggressive subtype of acute myeloid leukemia (AML) is caused by enhancer hijacking resulting in MECOM overexpression. Several chromosomal rearrangements can lead to this: the most common (inv(3)/t(3;3)) results in a hijacked GATA2 enhancer, and there are several atypical MECOM rearrangements involving enhancers from other hematopoietic ...
Joyce Vriend, Ruud Delwel, Dorien Pastoors   +2 more
wiley   +1 more source

A t (9;11) translocation in childhood acute mixed leukemia

São Paulo Medical Journal
We present the case of a child with acute lymphoid leukemia (ALL) who was morphologically classified as FAB L1 (PAS and peroxidase were negative). Remission was achieved with an ALL-type protocol (GBTLI). Five months after the discontinuation of therapy,
Maria de Lourdes Lopes Ferrari Chauffaille, Mihoko Yamamoto, Vicente Odone Filho, Maria Thereza Almeida, Paulo Maluf Jr., Lilian M. Cristofani, José Kerbauy, Suzana C. Raimondi   +7 more
doaj   +1 more source

Targeting the Menin–KMT2A interaction in leukemia: Lessons learned and future directions

International Journal of Cancer, EarlyView.
Abstract Chromosomal rearrangements involving the Mixed Lineage Leukemia gene (MLL1, KMT2A) are defining a genetically distinct subset in about 10% of human acute leukemias. Translocations involving the KMT2A‐locus at chromosome 11q23 are resulting in the formation of a chimeric oncogene, where the N‐terminal part of KMT2A is fused to a variety of ...
Florian Perner, Jayant Y. Gadrey, Scott A. Armstrong, Michael W. M. Kühn   +3 more
wiley   +1 more source