Results 101 to 110 of about 388,053 (254)

Critical Modulation of Hematopoietic Lineage Fate by Hepatic Leukemia Factor

Cell Reports, 2017
A gradual restriction in lineage potential of multipotent stem/progenitor cells is a hallmark of adult hematopoiesis, but the underlying molecular events governing these processes remain incompletely understood.
Martin Wahlestedt, Vasileios Ladopoulos, Isabel Hidalgo, Manuel Sanchez Castillo, Rebecca Hannah, Petter Säwén, Haixia Wan, Monika Dudenhöffer-Pfeifer, Mattias Magnusson, Gudmundur L. Norddahl, Berthold Göttgens, David Bryder   +11 more
doaj   +1 more source

Cytotoxic capacity of IL-15-stimulated cytokine-induced killer cells against human acute myeloid leukemia and rhabdomyosarcoma in humanized preclinical mouse models [PDF]

, 2012
Allogeneic stem cell transplantation (allo-SCT) has become an important treatment modality for patients with high-risk acute myeloid leukemia (AML) and is also under investigation for soft tissue sarcomas.
Wels, Winfried, Simone eFulda, Bader, Peter, Eva eRettinger, Koscielniak, Ewa, Winfried eWels, Meyer, Vida, Hermann eKreyenberg, Andreas eVolk, Selim Kuçi, Volk, Andreas, Simone Fulda, Thomas eKlingebiel, Willasch, Andre Manfred, Andreas Volk, Halvard Boenig, Klingebiel, Thomas, Kuçi, Selim, Peter Bader, Eva Rettinger, Thomas Klingebiel, Vida Meyer, Ewa eKoscielniak, Fulda, Simone, Andre eWillasch, Kreyenberg, Hermann, Halvard eBoenig, Bönig, Halvard-Björn, Rettinger, Eva, Vida eMeyer, Hermann Kreyenberg, Peter eBader, Selim eKuci, Ewa Koscielniak, Andre Willasch, Winfried S. Wels   +35 more
core   +1 more source

In Utero HSC Transplantation for Sickle Cell Disease: A Potential Therapeutic Approach That Overcomes Complications of Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide but has limited treatment options, most of which carry significant side effects. At present, the only curative treatment for SCD is allogeneic or gene‐modified autologous hematopoietic stem cell (HSC) transplantation (Tx).
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

Nanomedicine applications in lymphoma: Advancing precision diagnostics, targeted therapeutics, and prospective developments

VIEW, EarlyView.
Lymphoma is a group of blood cancers that can appear in lymph nodes, blood, bone marrow, spleen, liver, or the central nervous system, which makes drug delivery and disease monitoring difficult. This review summarizes how nanomedicine technologies may improve targeted treatment and imaging, while carefully separating approved or guideline‐supported ...
Mohd Ahmar Rauf, Yara Mashal, Afeefa Rao, Nasar Ata, Arun K. Iyer, Farhan Shah   +5 more
wiley   +1 more source

Basophils in Immunity: Activation Pathways, Roles in Allergy and AllergoOncology and Application of the Basophil Activation Test

Allergy, EarlyView.
ABSTRACT Basophils, the least abundant leukocytes, are increasingly recognised as potent immunomodulators. Upon activation, they rapidly release preformed granule‐associated mediators including histamine and lipid mediators such as LTC4, while cytokine production occurs over a longer timescale, contributing to downstream immune responses.
Jitesh Chauhan, Sofia Vlasova, Alicia Chenoweth, Debra H. Josephs, Heather J. Bax, Sophia N. Karagiannis   +5 more
wiley   +1 more source

Establishing Human Niche Xenograft Models for Myeloid and Lymphoid Leukemia Driven By MLL-AF9

, 2014
The MLL-AF9 fusion oncogene is found in pediatric leukemia of both the myeloid and lymphoid lineage, while in adults the same oncogene is predominantly associated with myeloid leukemia.
Martens, Anton C., Carretta, Marco, Jaques, Jennifer, Schuringa, Jan Jacob, de Boer, Bauke; id_orcid, de Boer, Bauke, Yuan, Huipin, Vellenga, Edo, Groen, Richard W. J.   +8 more
core  

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

Treatment of Leukemia Cutis Secondary to T-Cell Prolymphocytic Leukemia With Upadacitinib. [PDF]

EJHaem
eJHaem, Volume 7, Issue 5, October 2026.
Fraser K, Langille C, Chen LYC, Purdy K.
europepmc   +2 more sources

Neoplastic Risk in Patients With Klinefelter Syndrome

Andrology, EarlyView.
ABSTRACT Background Besides gonadal involvement (hypogonadism, male factor infertility, and testicular hypotrophy), patients with Klinefelter syndrome (KS) may suffer from several extra‐gonadic complications, including neoplastic events. Objective The aim of this review is to summarize all major clinical evidence dealing with the association between KS
Andrea Graziani, Giuseppe Grande, Riccardo Selice, Antonella Di Mambro, Alberto Ferlin   +4 more
wiley   +1 more source

Análise dos polimorfismos dos transcritos da translocação T(15;17)(Q22;Q21) na leucemia promielocítica aguda [PDF]

, 2013
TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Biologia.As leucemias agudas (LAs) constituem um grupo de neoplasias malignas caracterizado pela proliferação descontrolada de células hematopoiéticas na medula óssea
Silveira, Amanda da Silva
core