Results 21 to 30 of about 157,947 (291)

Effect of combining glucocorticoids with Compound A on glucocorticoid receptor responsiveness in lymphoid malignancies [PDF]

, 2018
Glucocorticoids (GCs) are a cornerstone in the treatment of lymphoid malignancies such as multiple myeloma (MM) and acute lymphoblastic leukemia (ALL).
Beck, Ilse, Clarisse, Dorien, De Bosscher, Karolien, Offner, Fritz, Tavernier, Jan, Van Wesemael, Karlien   +5 more
core   +3 more sources

Novel Markers in Pediatric Acute Lymphoid Leukemia: The Role of ADAM6 in B Cell Leukemia

Frontiers in Cell and Developmental Biology, 2021
BackgroundThe extensive genetic heterogeneity found in the B cell precursor acute lymphoblastic leukemia (BCP-ALL) subtype of childhood ALL represents a potential repository of biomarkers. To explore this potential, we have carried out in silico analysis
Laila Alsuwaidi, Mahmood Hachim, Mahmood Hachim, Abiola Senok   +3 more
doaj   +1 more source

The frequency of aberrant lymphoid antigens expression in 202 Iraqi patients with de novo acute myeloid leukemia

Iraqi Journal of Hematology, 2017
Background: Immunophenotyping improves both accuracy and reproducibility of acute leukemia classification and is considered, particularly useful for identifying acute myeloid leukemia (AML) with lymphoid marker expression.
Wafaa Mohammed Al-Anizi, Mohammed Abdul Rassoul Al-Mashta   +1 more
doaj   +1 more source

Biphenotypic Acute Leukemia versus Myeloid Antigen-Positive ALL: Clinical Relevance of WHO Criteria for Mixed Phenotype Acute Leukemia

Case Reports in Hematology, 2018
Updated WHO criteria define mixed phenotype acute leukemia (MPAL) with more stringent diagnostic criteria than the formerly described entity biphenotypic acute leukemia (BAL). The changes in diagnostic criteria influence management by assigning weight to
William A. Hammond, Pooja Advani, Rhett P. Ketterling, Daniel Van Dyke, James M. Foran, Liuyan Jiang   +5 more
doaj   +1 more source

Causal pathways in lymphoid leukemia: the gut microbiota, immune cells, and serum metabolites

Frontiers in Immunology
BackgroundWe employed Mendelian randomization (MR) to investigate the causal relationship between the gut microbiota and lymphoid leukemia, further exploring the causal relationships among immune cells, lymphoid leukemia, and potential metabolic ...
Xin Zhuang, Qingning Yin, Rong Yang, Xiaoying Man, Ruochen Wang, Hui Geng, Yifen Shi, Yifen Shi, Yifen Shi   +8 more
doaj   +1 more source

Retrovirus-Mediated Expression of E2A-PBX1 Blocks Lymphoid Fate but Permits Retention of Myeloid Potential in Early Hematopoietic Progenitors.

PLoS ONE, 2015
The oncogenic transcription factor E2A-PBX1 is expressed consequent to chromosomal translocation 1;19 and is an important oncogenic driver in cases of pre-B-cell acute lymphoblastic leukemia (ALL).
Mark W Woodcroft, Kyster Nanan, Patrick Thompson, Kathrin Tyryshkin, Steven P Smith, Robert K Slany, David P LeBrun   +6 more
doaj   +1 more source

Role of the bone morphogenic protein pathway in developmental haemopoiesis and leukaemogenesis [PDF]

, 2016
Myeloid leukaemias share the common characteristics of being stem cell-derived clonal diseases, characterised by excessive proliferation of one or more myeloid lineage.
Toofan, Parto, Wheadon, Helen
core   +1 more source

Clonal Evolution of B-Cell Acute Lymphoblastic Leukemia with del(9)(p13p21) into Mixed Phenotype Acute Leukemia Presenting as an Isolated Testicular Relapse

Reports, 2019
Lineage switch in acute leukemias is a well-reported occurrence; however, most of these cases involve a switch from either lymphoid to myeloid or myeloid to lymphoid lineage.
Lane H. Miller, Sunita I. Park, Debra Saxe, Glen Lew, Sunil S. Raikar   +4 more
doaj   +1 more source

Cytogenetic aberration in mixed-phenotype acute leukemia in children: A single-center retrospective review

Pediatrics and Neonatology, 2021
Background: Mixed-phenotype acute leukemia (MPAL) poses a diagnostic and therapeutic dilemma. No consensus exists on the strategy to assign patients with MPAL to either lymphoid- or myeloid-directed treatment.
Tsung-Yen Chang, Shih-Hsiang Chen, Tang-Her Jaing, Shu-Ho Yang, Yu-Chuan Wen, Chao-Ping Yang, Iou-Jih Hung   +6 more
doaj   +1 more source

Fludarabine as a cost-effective adjuvant to enhance engraftment of human normal and malignant hematopoiesis in immunodeficient mice [PDF]

, 2018
There is still an unmet need for xenotransplantation models that efficiently recapitulate normal and malignant human hematopoiesis. Indeed, there are a number of strategies to generate humanized mice and specific protocols, including techniques to ...
A Rambaldi, A Terenzi, AM Carroll, AM Carroll, BS Andersson, CR Giver, D Niederwieser, DA Frank, DE Mosier, E McCormack, F Aversa, IF Khouri, K Tajima, L Luznik, L Weiss, M Furukawa, NC Kirkiles-Smith, S Goyama   +17 more
core   +1 more source