Results 31 to 40 of about 92,971 (266)

Retrovirus-Mediated Expression of E2A-PBX1 Blocks Lymphoid Fate but Permits Retention of Myeloid Potential in Early Hematopoietic Progenitors.

PLoS ONE, 2015
The oncogenic transcription factor E2A-PBX1 is expressed consequent to chromosomal translocation 1;19 and is an important oncogenic driver in cases of pre-B-cell acute lymphoblastic leukemia (ALL).
Mark W Woodcroft, Kyster Nanan, Patrick Thompson, Kathrin Tyryshkin, Steven P Smith, Robert K Slany, David P LeBrun   +6 more
doaj   +1 more source

Clonal Evolution of B-Cell Acute Lymphoblastic Leukemia with del(9)(p13p21) into Mixed Phenotype Acute Leukemia Presenting as an Isolated Testicular Relapse

Reports, 2019
Lineage switch in acute leukemias is a well-reported occurrence; however, most of these cases involve a switch from either lymphoid to myeloid or myeloid to lymphoid lineage.
Lane H. Miller, Sunita I. Park, Debra Saxe, Glen Lew, Sunil S. Raikar   +4 more
doaj   +1 more source

Predictive value of proinflammatory activation in prognosis of cardiovascular events after treatment of chronic lymphoid leukemia

Zaporožskij Medicinskij Žurnal, 2017
Aim: To evaluate the prognostic value of circulating interleukin-6 and CD40 ligand in patients after chronic lymphoid leukemia treatment. Materials and Methods: 193 patients with chronic lymphoid leukemia after chemotherapy were included in the study.
B. B. Samura
doaj   +1 more source

A Tale of Two Hematological Malignancies: CML Followed by CLL in the Same Patient

Annals of Internal Medicine: Clinical Cases, 2023
Studies have reported second malignancies occurring in patients with chronic myeloid leukemia (CML) or chronic lymphoid leukemia (CLL). We discuss the case of a 77-year-old man diagnosed with CLL who later developed CML.
Insija Selene, Aasems Jacob, Zain Mary El-Amir, Sanjivani Sathe, Asma Taj   +4 more
doaj   +1 more source

A retinoic acid-dependent stroma-leukemia crosstalk promotes chronic lymphocytic leukemia progression

Nature Communications, 2018
The stromal microenvironment plays a key role in the expansion of chronic lymphocytic leukemia. Here, the authors use the Eµ-TCL1 mouse model to show that leukemic B-cells induce the activation of retinoic acid synthesis in stromal cells of the lymphoid ...
Diego Farinello, Monika Wozińska, Elisa Lenti, Luca Genovese, Silvia Bianchessi, Edoardo Migliori, Nicolò Sacchetti, Alessia di Lillo, Maria Teresa Sabrina Bertilaccio, Claudia de Lalla, Roberta Valsecchi, Sabrina Bascones Gleave, David Lligé, Cristina Scielzo, Laura Mauri, Maria Grazia Ciampa, Lydia Scarfò, Rosa Bernardi, Dejan Lazarevic, Blanca Gonzalez-Farre, Lucia Bongiovanni, Elias Campo, Andrea Cerutti, Maurilio Ponzoni, Linda Pattini, Federico Caligaris-Cappio, Paolo Ghia, Andrea Brendolan   +27 more
doaj   +1 more source

Cytogenetic aberration in mixed-phenotype acute leukemia in children: A single-center retrospective review

Pediatrics and Neonatology, 2021
Background: Mixed-phenotype acute leukemia (MPAL) poses a diagnostic and therapeutic dilemma. No consensus exists on the strategy to assign patients with MPAL to either lymphoid- or myeloid-directed treatment.
Tsung-Yen Chang, Shih-Hsiang Chen, Tang-Her Jaing, Shu-Ho Yang, Yu-Chuan Wen, Chao-Ping Yang, Iou-Jih Hung   +6 more
doaj   +1 more source

Analysis of lymphocytic leukemia trends among gender, race, age, and regional groups in the U.S. between 1999-2022: a CDC-WONDER database study

Frontiers in Oncology
BackgroundLymphocytic leukemia (LL) is a prominent group of hematological cancers afflicting both children and adults of all backgrounds and demographics.
Shannon Blee, Bob Weng, Taylor Billion, Ali Bin Abdul Jabbar, Abubakar Tauseef, Mohsin Mirza   +5 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Prevalence of Leukemia and Associated Factors among Patients with Abnormal Hematological Parameters in Jimma Medical Center, Southwest Ethiopia: A Cross-Sectional Study

Advances in Hematology, 2020
Introduction. Leukemia is a heterogeneous group of hematological disorder which comprise several diverse and biologically distinct subgroups. Leukemia represents the 11th and 10th most frequent cause of cancer morbidity and mortality worldwide ...
Woldeteklehaymanot Kassahun, Girum Tesfaye, Lealem Gedefaw Bimerew, Diriba Fufa, Wondimagen Adissu, Tilahun Yemane   +5 more
doaj   +1 more source

Treatment of Acute Lymphoid Leukemia Refractory to Classic First-Line and Rescue Protocols

International Journal of Hematology-Oncology and Stem Cell Research, 2020
Acute Lymphoblastic Leukemia is a very aggressive malignant disorder of lymphoid cells in adults, with recurrence (30 to 60% of the cases) after the initial treatment.
Flávia Tobaldini Russo, Maria Cristina Martins de Almeida Macedo, Pedro Amoedo Fernandes, Larissa Yukari Okada, Lucas Augusto Monetta da Silva, Camila Menin Simões, Jamilla Neves Cavalcante, Aline de Almeida Simões, Manuella de Souza Sampaio Almeida, Maricy Almeida Viol Ferreira Lopes, Roberto Luiz da Silva   +10 more
doaj   +1 more source