Results 21 to 30 of about 388,053 (254)

Identification of cooperating genetic events in acute leukemia [PDF]

, 2009
The genetic alterations associated with acute leukemia can be divided into two functional groups. The class I mutations enhance cellular proliferation and survival by constitutive activation of mainly protein tyrosine kinases signaling pathways.
Liu, Ting
core   +1 more source

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

Hepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan, André Megarbane, Aziz Chouchane, Deepak Karthik, Ramzi Temanni, Atilio Reyes Romero, Huiying Hua, Chun Pan, Xixi Chen, Murugan Subramanian, Chadi Saad, Hamdi Mbarek, Cybel Mehawej, Eliane Chouery, Sirin W. Abuaqel, Alexander Dömling, Sami Remadi, Cesar Yaghi, Pu Li, Lotfi Chouchane   +19 more
wiley   +1 more source

A novel spliced fusion of MLL with CT45A2 in a pediatric biphenotypic acute leukemia [PDF]

, 2010
Background: Abnormalities of 11q23 involving the MLL gene are found in approximately 10% of human leukemias. To date, nearly 100 different chromosome bands have been described in rearrangements involving 11q23 and 64 fusion genes have been cloned and ...
Meyer, Claus, Santos Joana, Claus Meyer, Lucília Norton, Susana Bizarro, Lisboa, Susana, Joana Santos, Cecília Correia, Lisboa Susana, Susana Lisboa, Meyer Claus, Teixeira Manuel R, Nuno Cerveira, Torres, Lurdes, Marschalek Rolf, Torres Lurdes, Norton Lucília, Correia, Cecilia, Pinheiro Manuela, Santos, Joana, Bizarro, Susana, Correia Cecília, Teixeira, Manuel R., Manuel R Teixeira, Pinheiro, Manuela, Cerveira Nuno, Marschalek, Rolf (Prof. Dr.), Rolf Marschalek, Lurdes Torres, Manuela Pinheiro, Cerveira, Nuno, Norton, Lucilia, Bizarro Susana   +32 more
core   +2 more sources

Characterization of lymphoid tissue inducer cells and lymphoid tissue development in adult interleukin 7 transgenic mice [PDF]

, 2008
During embryogenesis, the development of secondary lymphoid organs (SLOs) such as lymph nodes (LNs) and Peyer’s patches (PPs) requires the cellular crosstalk between vascular cell adhesion molecule (VCAM)-1+ mesenchymal organizer cells and CD45+CD4 ...
Schmutz, Sandrine
core   +1 more source

A comprehensive microarray-based DNA methylation study of 367 hematological neoplasms [PDF]

, 2011
Background: Alterations in the DNA methylation pattern are a hallmark of leukemias and lymphomas. However, most epigenetic studies in hematologic neoplasms (HNs) have focused either on the analysis of few candidate genes or many genes and few HN entities,
Dreyling, Martin, Stein, Harald, Agirre, Xabier, Vater, Inga, Hartmann, Sylvia, Martin-Subero, Jose Ignacio, Deckert, Martina, Román-Gómez, José, Haferlach, Claudia, Küppers, Ralf, Bug, Stefanie, Bibikova, Marina, Harder, Lana, Nagel, Inga, Montesinos-Rongen, Manuel, Trümper, Lorenz, Hansmann, Martin-Leo, Suela, Javier, Calasanz, Maria J., Gesk, Stefan, Cruz Cigudosa, Juan, Wickham-Garcia, Eliza, Du, Ming Q., Siebert, Reiner, Seifert, Marc, Richter, Julia, Klapper, Wolfram, Brüggemann, Monika, Dyer, Martin J. S., Ammerpohl, Ole, Fan, Jian-Bing, Dürig, Jan, Alvarez, Sara, Pott, Christiane, Prosper, Felipe   +34 more
core   +2 more sources

Obesity is a risk factor for acute promyelocytic leukemia: evidence from population and cross-sectional studies and correlation with FLT3 mutations and polyunsaturated fatty acid metabolism

Haematologica, 2020
Obesity correlates with hematologic malignancies including leukemias, but risk of specific leukemia subtypes like acute promyelocytic leukemia and underlying molecular mechanisms are poorly understood.
Luca Mazzarella, Edoardo Botteri, Anthony Matthews, Elena Gatti, Davide Di Salvatore, Vincenzo Bagnardi, Massimo Breccia, Pau Montesinos, Teresa Bernal, Cristina Gil, Timothy J Ley, Miguel Sanz, Krishnan Bhaskaran, Francesco Lo Coco, Pier Giuseppe Pelicci   +14 more
doaj   +1 more source

Uncommon CD markers in acute myeloid leukemia

Bangabandhu Sheikh Mujib Medical University Journal, 2018
This study was done to assess the unusual CD expression in 100 cases of acute myeloid leukemia from October 2016 to April 2018. The age limit was from 3 to 50 years.
Azad Abul Kalam, Md. Rafiquzzaman Khan, A. B. M. Hassan Habib, Masuda Begum   +3 more
doaj   +1 more source

Superoxide Dismutase and Vitamin E Levels in Serum as Indicators in Patients with Acute and Chronic Leukemia [PDF]

Journal of Applied Sciences and Nanotechnology, 2022
Oxidative stress has been linked to the development of a variety of malignancies, including leukemia. Furthermore, the incidence of leukemia increases with age due to an increase in the number of free radicals reacting with age and a lower ability of the
Reem Al-Qaisi, Abdulnasser Al-Gebori, Mohammed Alosami   +2 more
doaj   +1 more source

Biphenotypic Acute Leukemia versus Myeloid Antigen-Positive ALL: Clinical Relevance of WHO Criteria for Mixed Phenotype Acute Leukemia

Case Reports in Hematology, 2018
Updated WHO criteria define mixed phenotype acute leukemia (MPAL) with more stringent diagnostic criteria than the formerly described entity biphenotypic acute leukemia (BAL). The changes in diagnostic criteria influence management by assigning weight to
William A. Hammond, Pooja Advani, Rhett P. Ketterling, Daniel Van Dyke, James M. Foran, Liuyan Jiang   +5 more
doaj   +1 more source

The frequency of aberrant lymphoid antigens expression in 202 Iraqi patients with de novo acute myeloid leukemia

Iraqi Journal of Hematology, 2017
Background: Immunophenotyping improves both accuracy and reproducibility of acute leukemia classification and is considered, particularly useful for identifying acute myeloid leukemia (AML) with lymphoid marker expression.
Wafaa Mohammed Al-Anizi, Mohammed Abdul Rassoul Al-Mashta   +1 more
doaj   +1 more source