Results 111 to 120 of about 554,772 (269)

Emerging applications of long-read sequencing in hematological malignancies: highlights from the 2025 ASH annual meeting. [PDF]

Biomark Res
Liu B, Jiang Y, Zhao B, Zhu HH.
europepmc   +1 more source

NUDT21 Drives T‐Cell Acute Lymphoblastic Leukemia Through Dual Regulation of Alternative Polyadenylation and Transcriptional Activation

Advanced Science, EarlyView.
In summary, our study defines a coordinated oncogenic model in which NUDT21 integrates alternative polyadenylation–dependent UBE2D3 stabilization and transcriptional activation to sustain MYC‐driven T‐ALL cell survival, thereby establishing NUDT21 as a central regulatory node and a promising therapeutic target.
Conglian Qiu, Jianwei Wang, Zhiheng Li, Qi Ji, Hui Zhang, Qinyi Zhang, Senlin Zhang, Juanjuan Yu, Yanfang Tao, Yijun Wu, Chunxia Shi, Zong Zai, Zimu Zhang, Yizhen Li, Zhenjiang Bai, Shaoyan Hu, Jian Pan, Yang Yang, Shuiyan Wu   +18 more
wiley   +1 more source

Rare coincident NPM1 and RUNX1 mutations in intermediate risk acute myeloid leukemia display similar patterns to single mutated cases

Haematologica, 2014
Annette Fasan, Claudia Haferlach, Alexander Kohlmann, Frank Dicker, Christiane Eder, Wolfgang Kern, Torsten Haferlach, Susanne Schnittger   +7 more
doaj   +1 more source

A gene signature derived from leukemia associated macrophages provides a compelling risk stratification for human AML patients. [PDF]

Biomark Res
Nicolet D, Zhang T, Walker CJ, Ameyi J, Mori SF, Fang X, Zhang L, Cortes J, Hedrick CC, Cowell JK, Eisfeld AK, Hu T.   +11 more
europepmc   +1 more source

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source

“Somatic” and “pathogenic” - is the classification strategy applicable in times of large-scale sequencing?

Haematologica, 2019
Constance Baer, Wencke Walter, Stephan Hutter, Sven Twardziok, Manja Meggendorfer, Wolfgang Kern, Torsten Haferlach, Claudia Haferlach   +7 more
doaj   +1 more source

P576: A PHASE I/II STUDY OF MILADEMETAN (DS3032B) IN COMBINATION WITH LOW DOSE CYTARABINE WITH OR WITHOUT VENETOCLAX IN ACUTE MYELOID LEUKEMIA

HemaSphere, 2022
J. Senapati, J. Ishizawa, H. A. Abbas, S. Loghavi, G. Borthakur, G. C. Issa, S. I. Dara, R. Pourebrahim, N. Daver, E. J. Jabbour, S. M. Kornblau, N. Pemmaraju, G. Garcia-Manero, F. Ravandi, M. Muftuoglu, J. Khoury, C. DiNardo, M. Andreeff   +17 more
doaj   +1 more source

Using period analysis to timely provide serial data on long-term survival for patients with hematological malignancies from Taizhou, Eastern China. [PDF]

Front Oncol
Mo X, Bing X, Hua L, Xu C, Lei R, Chen X, Song Y, Chen T.   +7 more
europepmc   +1 more source

CD28‐Targeted Enzyme‐Responsive Conformation‐Switching Peptide Self‐Assembly for Selective T‐Cell Acute Lymphoblastic Leukemia (T‐ALL) Therapy

Advanced Science, EarlyView.
We developed the enzyme‐responsive peptide SAp‐CD28 to selectively target CD28‐overexpressing T‐ALL cells. Following phosphatase‐mediated activation, SAp‐CD28 undergoes conformational switching and nanooligomerization, resulting in the disruption of CD28 downstream signaling.
Jun Li, Ziyu Jia, Dekun Li, Zhi‐Wen Hu, Yinghao Ding, Shengyi Zhang, Shengkun Tuo, Zhimou Yang, Huisheng Fu, Ling Wang, Man‐Di Wang   +10 more
wiley   +1 more source

Myeloid neoplasms with MYC-positive double minutes: towards recognition as a distinct entity

Blood Cancer Journal
Isolde Summerer, Wencke Walter, Manja Meggendorfer, Torsten Haferlach, Frank Dicker, Stephan Hutter, Niroshan Nadarajah, Anna Stengel, Constanze Kuehn, Wolfgang Kern, John M. Bennett, Claudia Haferlach, Christian Pohlkamp   +12 more
doaj   +1 more source