Results 91 to 100 of about 734,180 (319)

Targeting Susceptible Signaling Pathways in Chronic Lymphocytic Leukemia [PDF]

, 2016
Chronic lymphocytic leukemia (CLL) is a cancer of B cells and is the most common leukemia in North America. Current therapies are fraught with challenges, and drug resistance and disease relapse remain common occurrences.
Dielschneider, Rebecca
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Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Epigenetic landscape correlates with genetic subtype but does not predict outcome in childhood acute lymphoblastic leukemia [PDF]

, 2015
Although children with acute lymphoblastic leukemia (ALL) generally have a good outcome, some patients do relapse and survival following relapse is poor.
Mitchell, Chris D, Steven C Clifford (779057), Gabriel, Alem, Clifford, Steven, Schwalbe, Edward C, Mitchell, Chris, Nakjang, Sirintra, Alem S Gabriel (779049), Clifford, Steven C, Lafta, Fadhel M, Strathdee, Gordon, Simon J Cockell (779052), Kinsey, Sally, Vikki Rand (779056), Iliasova, Alice, Christine J Harrison (779061), Schwalbe, Ed, Harrison, Christine, Anthony V Moorman (779062), Lafta, Fadhel, Kinsey, Sally E, Sally E Kinsey (779058), Chris D Mitchell (779059), Vora, Ajay, Cockell, Simon J, Rand, Vikki, Edward C Schwalbe (779051), Gordon Strathdee (779063), Enshaei, Amir, Sirintra Nakjang (124590), Harris, Christine J, Gabriel, Alem S, Moorman, Anthony, Amir Enshaei (779054), Fadhel M Lafta (779050), Claire Schwab (779055), Moorman, Anthony V, Rand, Vikki; id_orcid, Schwab, Claire, Ajay Vora (779060), Cockell, Simon, Alice Iliasova (779053)   +41 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

P506: ACHIEVEMENT OF MEASURABLE RESIDUAL DISEASE CLEARANCE IS A STRONGER PREDICTOR OF PATIENT OUTCOME THAN TREATMENT INTENSITY IN NEWLY DIAGNOSED PATIENTS WITH ACUTE MYELOID LEUKEMIA

HemaSphere, 2022
A. Bazinet, T. Kadia, N. Short, G. Borthakur, S. Wang, S. Loghavi, J. Jorgensen, K. Patel, C. DiNardo, N. Daver, Y. Alvarado, F. Haddad, S. Pierce, M. Andreeff, E. Jabbour, M. Konopleva, H. Kantarjian, F. Ravandi   +17 more
doaj   +1 more source

Leukemia surveillance report no. 3, July 1971 [PDF]

This report contains data obtained through a program of leukemia surveillance established by the Center for Disease Control in 1966, in collaboration with certain state and local health departments.

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Negative Prognostic Impact Of Pten Mutation In Pediatric T-cell Acute Lymphoblastic Leukemia [PDF]

, 2015
[No abstract available]241239242Silva, A., Yunes, J.A., Cardoso, B.A., Martins, L.R., Jotta, P.Y., Abecasis, M., PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability (2008) J Clin ...
Barata J.T., Viana M.B., Zambaldi L.J.G., Jotta P.Y., Ganazza M.A., Da Silva M.J., Yunes J.A., Silva A., Brandalise S.R.   +8 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Leukemia surveillance program report no. 2, December 1, 1967 [PDF]

The leukemia surveillance program was begun in 1966 by the National Communicable Disease Center (NCDC) in association with the National Cancer Institute (NCI). The program consists of a series of leukemia case reporting projects in different parts of the

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Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6 [PDF]

, 2013
The authors acknowledge TENOVUS Tayside for funding the studyTenovin-6 (Tnv-6) is a bioactive small molecule with anti-neoplastic activity. Inhibition of the Sirtuin class of protein deacetylases with activation of p53 function is associated with the pro-
Coates, Philip J., Groves, M.J., Prescott, A.R., Nicolaou, A., Murray, Karen, Ganley, Ian G.; id_orcid, Lain, S., Tauro, S., Haydock, S., Appleyard, V., Ganley, I.G., James, John, Nicolaou, Anna; id_orcid, Cunningham, Joan, Cunningham, J., Tauro, Sudhir, Murray, K., Prescott, Alan R., Drbal, Abed Alnaser A.A., Coates, P.J., James, J., MacCallum, S., Lain, Sonia, Drbal, A.A., MacCallum, Stephanie F., Drbal, Abed A., Haydock, Sally, Westwood, N.J., Prescott, Alan R.; id_orcid, Ganley, Ian G., Groves, Michael J., Nicolaou, Anna, Westwood, Nicholas J., Appleyard, Virginia   +33 more
core   +1 more source