Results 61 to 70 of about 802,617 (317)

Relationship between FLT3 mutation status, biologic characteristics, and response to targeted therapy in acute promyelocytic leukemia [PDF]

, 2005
The prognostic significance of FLT3 mutations in acute promyelocytic leukemia (APL) is not firmly established and is of particular interest given the opportunities for targeted therapies using FLT3 inhibitors.
Gilkes, Amanda F., Ellen Solomon, Linch, D C, Gale, Rosmary E., Burnett, Alan Kenneth, Gale, RE, David C. Linch, Pizzey, AR, Elizabeth Nugent, Keith Wheatley, Grimwade, D., Grimwade, D, Solomon, E, Pizzey, A R, Solomon, Ellen, Kenneth I. Mills, Swirsky, D, Pizzey, A.R., Burnett, A K, Alan K. Burnett, Hills, Robert Kerrin, Swirsky, David, Kottaridis, Panagiotis D., Grimwade, David, Linch, David C., ?, ?, Hills, R., David Swirsky, Gale, R E, Gilkes, A F, Kottaridis, PD, Solomon, E., Robert Hills, Linch, D.C., Arnold R. Pizzey, Nugent, E., Rosemary E. Gale, Mills, KI, Nugent, Elizabeth, Gale, R.E., Swirsky, D., Hills, Robert, Hills, R, NCRI Adult Leukaemia Working Party, David Grimwade, Kottaridis, P D, Linch, DC, Wheatley, K., Amanda F. Gilkes, Wheatley, Keith, Gilkes, AF, Nugent, E, Panagiotis D. Kottaridis, Mills, K I, Mills, Ken; id_orcid, Kottaridis, P.D., Burnett, AK, Burnett, A.K., Mills, Kenneth I., Gilkes, A.F., Wheatley, K, Pizzey, Arnold R.   +61 more
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

P371: HYPER-CVAD WITH SEQUENTIAL BLINATUMOMAB, WITH OR WITHOUT INOTUZUMAB OZOGAMICIN, IN ADULTS WITH NEWLY DIAGNOSED PHILADELPHIA CHROMOSOME-NEGATIVE B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA

HemaSphere, 2022
N. Short, H. Kantarjian, F. Ravandi, M. Yilmaz, T. Kadia, P. Thompson, X. Huang, M. Konopleva, A. Ferrajoli, N. Jain, K. Sasaki, Y. Alvarado, G. Borthakur, C. Dinardo, M. Ohanian, W. Macaron, S. Kornblau, M. Zhao, M. Kwari, C. Loiselle, R. Delumpa, A. Milton, J. Rivera, S. Lewis, R. Garris, E. Jabbour   +25 more
doaj   +1 more source

Serial assessment of suspected myelodysplastic syndromes: significance of flow cytometric findings validated by cytomorphology, cytogenetics, and molecular genetics

Haematologica, 2013
The significance of flow cytometry indicating myelodysplasia without proof of myelodysplasia by cytomorphology remains to be clarified. We evaluated follow-up analyses in 142 patients analyzed in parallel by flow cytometry, cytomorphology and ...
Wolfgang Kern, Claudia Haferlach, Susanne Schnittger, Tamara Alpermann, Torsten Haferlach   +4 more
doaj   +1 more source

Continuing high early death rate in acute promyelocytic leukemia: a population-based report from the Swedish Adult Acute Leukemia Registry

, 2011
Our knowledge about acute promyelocytic leukemia (APL) patients is mainly based on data from clinical trials, whereas population-based information is scarce.
S Lehmann, Derolf, A. R., M Höglund, S Deneberg, Antunovic, P, Juliusson, G, Stockelberg, D.,, Möllgård, L, Wennstrom, L., Wennström, L, A Ravn, P Antunovic, Ravn, A., Carlsson, L., Derolf, A Rangert, Wennstrom, L.,, Antunovic, P., Hoglund, M.,, Rangert Derolf, Å, Lehmann, S.,, Tidefelt, U, D Stockelberg, Carlsson, L, Hoglund, M., Antunovic, Petar,, A Wahlin, Carlsson, L.,, Lehmann, S, L Möllgård, G Juliusson, Å Rangert Derolf, Deneberg, S., Tidefelt, Ulf,, Höglund, Martin,, Stockelberg, D, Wahlin, A, Lund University., Juliusson, Gunnar, L Wennström, Mollgard, L., Derolf, A. Rangert, Juliusson, Gunnar,, Ravn, S, Ravn, A, Lehmann, S., Juliusson, G., Wennström, Lovisa,, Stockelberg, D., Wahlin, A., Tidefelt, U., Rangert Derolf, A.,, Lehmann, Sören, Mollgard, L.,, Deneberg, S, Höglund, M, Ravn, A.,, U Tidefelt, Wahlin, A.,, Wahlin, Anders,, Juliusson, G.,, Tidefelt, U.,, L Carlsson, Stockelberg, Dick,, Högberg, M, Deneberg, S.,   +64 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

S149: LONG TERM OUTCOMES OF IFCG REGIMEN FOR FIRSTLINE TREATMENT OF PATIENTS WITH CLL WITH MUTATED IGHV AND WITHOUT DEL(17P)/TP53 MUTATION

HemaSphere, 2022
N. Jain, P. Thompson, J. Burger, A. Ferrajoli, K. Takahashi, Z. Estrov, G. Borthakur, P. Bose, T. Kadia, N. Pemmaraju, K. Sasaki, M. Konopleva, E. Jabbour, N. Garg, X. Wang, R. Kanagal-Shamanna, K. Patel, W. Wang, S. Wang, J. Jorgensen, W. Lopez, A. Ayala, W. Plunkett, V. Gandhi, H. Kantarjian, S. O’Brien, M. Keating, W. Wierda   +27 more
doaj   +1 more source

Late effects in survivors of infant leukemia

, 2000
Little is known about the incidence of and risk factor for late effects of infant leukemia. We evaluated 19 children with acute lymphoblastic leukemia and 15 with acute myeloid leukemia who were diagnosed at age 12 months or younger and have survived for
Sandlund, J. T., Evans, W. E., Leung, W., Bowman, L. C., Kun, L., Ribeiro, R. C., Pui, C. H., Rivera, G. K., Hudson, M., Zhu, Y.   +9 more
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

P770: A COMPARATIVE STUDY OF LEUKEMIC TRANSFORMATION IN THERAPY-RELATED AND DE NOVO MYELODYSPLASTIC SYNDROME AFTER HYPOMETHYLATING AGENT FAILURE

HemaSphere, 2022
K. Kim, F. Ong, Z. Li, R. Kanagal-Shamanna, G. Montalban-Bravo, T. Kadia, E. Jabbour, N. Pemmaraju, D. Hammond, N. Short, F. Ravandi, Y. Alvarado, S. Pierce, X. Q. Dong, H. Kantarjian, G. Garcia-Manero, K. Chien   +16 more
doaj   +1 more source