Results 181 to 190 of about 152,467 (287)

SHBs Mitigates Sorafenib‐Induced Apoptosis in Hepatocellular Carcinoma via Activation of RAF1/MEK/ERK Signaling Pathway

Cancer Science, EarlyView.
Hepatitis B virus (HBV) infection is a major driver of hepatocellular carcinoma (HCC) and is associated with resistance to sorafenib, the first‐line treatment for advanced HCC. This study demonstrates that the small HBV surface antigen (SHBs) promotes sorafenib resistance by activating the RAF1/MEK/ERK signaling pathway, inhibiting apoptosis in HCC ...
Shuxiang Wu, Yuxiang Hong, Hang Li, Mengxian Lin, Xiaohuang Lin, Xinjian Lin, Xu Lin   +6 more
wiley   +1 more source

Radiographic Peri‐Implant Bone Changes in Osteoporotic Women Treated With a Ti‐Zr, Bone Level Tapered Implant With a Hydrophilic Surface: A 12‐Month Prospective Case‐Series

Clinical Oral Implants Research, EarlyView.
ABSTRACT Objectives This study assessed 12‐month post‐loading 3D peri‐implant radiographic bone changes in osteoporotic women receiving a single titanium‐zirconium bone‐level tapered dental implant with a hydrophilic surface. Materials and Methods This was a prospective case series involving 18 post‐menopausal osteoporotic women in need of a single ...
Calciolari Elena, Mardas Nikos, Palaska Iro, Tagliaferri Sara, Donos Nikolaos   +4 more
wiley   +1 more source

Targeting SHP‐1‐Mediated Inhibition of STAT3 and ERK Signalling Pathways Rescues the Hyporesponsiveness of MHC‐I‐Deficient NK‐92MI

Cell Proliferation, EarlyView.
B2M knockout (KO) represents a crucial strategy for generating universal NK‐92MI cell products. This approach results in increased phosphorylation of SHP‐1 and inhibited phosphorylation of STAT3 and ERK, which ultimately affect their cytotoxic capabilities. SHP‐1 KO facilitates the restoration of cytotoxic function in B2M KO NK‐92MI cells.
Kuo Yu, Xiaolong Liu, Guangyuan Wu, Zhongyao An, Xin Wang, Yang Liu, Hailong Wang, Mingli Huang, Linlin Zhao, Ce Shi, Xin Sun, Lu Xu, Sen Qi, Xin Zhang, Yueqiu Teng, Song Guo Zheng, Zhiren Zhang, Zhenkun Wang   +17 more
wiley   +1 more source

Maternal Nutritional Status Governs Fetal Development by Modulating Imprinting Gene GAB1‐Mediated Trophoblast Differentiation in the Placenta

Cell Proliferation, EarlyView.
Maternal nutrient restriction disrupts placental homeostasis via GAB1 dysregulation—involving both transcriptional downregulation and autophagy‐dependent protein degradation. These molecular alterations inhibit MAPK signalling‐mediated trophoblast fusion, leading to structural and functional deficits in the maternal–fetal exchange interface.
Mingming Fan, Hongyu Wu, Yuan Xie, Ming Liu, Xin Yu, Feiyang Wang, Zhenyu Xiao, Hongmei Wang, Xuan Shao, Yan‐Ling Wang   +9 more
wiley   +1 more source

Pyrimethamine Triggers the Apoptotic Pathway in Mucoepidermoid Carcinoma in Cell‐Based Models

Journal of Oral Pathology &Medicine, EarlyView.
ABSTRACT Background Mucoepidermoid carcinoma (MEC) is the most prevalent salivary gland malignancy, with a poor prognosis in high‐grade tumors at diagnosis. This highlights the need for effective antitumor agents for treating MEC. Therefore, we aimed to investigate the antineoplastic efficacy of pyrimethamine (PYR), a Food and Drug Administration ...
Hyun‐Ji Kim, Dong‐Guk Park, Su‐Jung Choi, Jae‐Jin Cho, Seong‐Doo Hong, Sung‐Dae Cho   +5 more
wiley   +1 more source

Frecuencia de leucosis enzoótica bovina en hatos bovinos del Eje Cafetero, Colombia [PDF]

, 2018
La leucosis enzoótica bovina (LEB) es una enfermedad del ganado bovino adulto causada por el retrovirus de la leucemia bovina (BLV). El ganado puede infectarse a cualquier edad, incluida la fase embrionaria. La mayoría de las infecciones son subclínicas,
Martínez Medina, María Alejandra, Ramírez González, Wendy Catalina   +1 more
core  

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

Journal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed, Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Aiah A. El‐Rashidy, Marwa M. S. Abbass, Christof E. Dörfer   +6 more
wiley   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, Volume 19, Issue 8, Page 2431-2455, August 2025.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Fast pH‐Driven Solubilization Method of Realgar (As4S4) to Reduce the Toxicity of Arsenic [As(III)] for Medicinal Purposes

Advanced Science, Volume 12, Issue 29, August 7, 2025.
Arsenic trioxide transformed acute promyelocytic leukemia therapy and shows promise against HIV. A new method to solubilize the mineral realgar produces different arsenic species depleting the main arsenic target, nuclear PML protein, and retaining effects on leukemic and HIV reservoir cells, while minimizing off‐target damage.
Bojana Lucic, Douglas Santana Franciscato, Helton Pereira Nogueira, Lara Gallucci, Alceu Totti Silveira Junior, Asmaa Mohamed Ismail, Millie Robinson, Teresa Dallinger, Claudia Gutfleisch, Jochen Kurz, Maytê Toledo, Jessica Dias da Silva Ferraz, Mohammad Tarek, Danilo Dias, Ricardo Sobhie Diaz, Mahmoud ElHefnawi, Mattia Forcato, Hugo P Monteiro, Marina Lusic, Iart Luca Shytaj, Andrea Savarino   +20 more
wiley   +1 more source

Multi‐omics integration analysis identifies INPP4B as a T‐cell‐specific activation suppressor

Clinical and Translational Medicine, Volume 15, Issue 8, August 2025.
A comprehensive multi‐omics characterisation of INPP4B across immune cell populations. Discovery of a T‐cell‐specific expression and interaction domain of INPP4B. INPP4B functions as a T‐cell‐specific activation suppressor. INPP4B is upregulated in exhausted T cells within the tumour microenvironment. Abstract Background Naïve T cells are maintained in
Ting Peng, Qing Fang, Zihao Zhao, Yingjun Chang, Xiangyu Zhao, Cheng Li   +5 more
wiley   +1 more source