Results 191 to 200 of about 152,467 (287)

Discovering new hub genes of dilated cardiomyopathy

ESC Heart Failure, Volume 12, Issue 4, Page 2487-2498, August 2025.
Abstract Aims Dilated cardiomyopathy (DCM) has a poor prognosis and exhibits a complex and diverse aetiology and genetic profile. The genes responsible for the pathogenesis of DCM have not been fully identified. The present study aimed to explore new hub genes of DCM by mining the human DCM databases and further by experimental validation.
Jun‐Yan Zhu, Yu Han, Jing‐Yu Yang, De‐Ping Wang, Li‐Juan Gao, Teng Sun, Yan‐Lin Feng, Zhong‐Mei He, Bin Zhou, Ji‐Min Cao   +9 more
wiley   +1 more source

Study of prevalence, risk factors, and lifetime impacts of infection with bovine leukemia virus in the Canadian dairy industry

, 2015
The overall goal of the research described in this thesis was to lay a proper foundation for designing and conducting efficient control and eradication programs for infection with bovine leukemia virus (BLV) in the Canadian dairy industry.

core  

Generation of Regulatory T Cells From Human Memory CD4+T Cells by Upregulation of Naked Cuticle Homolog 2

European Journal of Immunology, Volume 55, Issue 8, August 2025.
This study discovered the small molecule 9‐methoxy‐6‐methylindolo[3,2‐b] quinoxaline (IFA005) as a potent immunomodulator capable of converting human memory CD4⁺ T cells into functional Foxp3⁺ regulatory T cells. IFA005 suppresses Th2 cytokines (IL‐4, IL‐5, and IL‐13) and promotes the iTreg phenotype by inhibiting Wnt/β‐catenin signaling through NKD2 ...
Jiajun He, Kristy Ou, Michael Schmueck‐Henneresse, Edgar Specker, Jérôme Paul, Marc Nazare, Jens Peter von Kries, Julia K. Polansky, Alf Hamann, Stefan Frischbutter   +9 more
wiley   +1 more source

GREM1 deficiency induced bone marrow adipose niche promotes B‐cell acute lymphoblastic leukemia disease progression

International Journal of Cancer, Volume 157, Issue 3, Page 559-572, 1 August 2025.
What's new? Too often, children treated for B‐cell acute lymphocytic leukemia (B‐ALL) experience relapse. Here, the authors investigate the role of dyslipidemia in leukemia progression. Higher adipogenicity in bone marrow mesenchymal stem cells, and increased triglyceride accumulation, are associated with higher risk of death.
Lili Song, Rui Zhang, Liya Pan, Qiang Mi, Yi Yang, Xiang Wang, Yani Ma, Shuhong Shen, Benshang Li, Yanxin Li, Li Hong   +10 more
wiley   +1 more source

Seroprevalence and Molecular Analysis of Bovine Leukemia Virus in Kazakhstan. [PDF]

Viruses
Mamanova S, Nurpeisova A, Bashenova E, Kaimoldina S, Kirpichenko V, Akshalova P, Karabassova A, Yussupov M, Mashzhan A, Tazhbayeva D, Abay Z, Rola-Luszczak M, Kuzmak J, Nissanova R, Kassenov M.   +14 more
europepmc   +1 more source

Inhibitors of Tax1‐PDZ Interactions Block HTLV‐1 Viral Transmission by Changing EV Composition

Journal of Extracellular Vesicles, Volume 14, Issue 8, August 2025.
ABSTRACT Extracellular vesicles (EVs) are known to facilitate infection by enveloped RNA viruses including the Human T‐cell leukemia virus type‐1 (HTLV‐1). HTLV‐1‐encoded proteins, like the transactivator and oncoprotein Tax‐1, are loaded into EVs but their precise impact on EV cargos is not yet known.
Jedidja Puttemans, Yasmine Brammerloo, Karim Blibek, Jeremy Blavier, Thandokuhle Ntombela, Inge Van Molle, Julie Joseph, Julien Olivet, Deeya Saha, Manon Degey, Malik Hamaidia, Pooja Jain, Piel Geraldine, Pascale Zimmermann, Dae‐Kyum Kim, Dominique Baiwir, Makon‐Sébastien Njock, Franck Dequiedt, Kourosh Salehi‐Ashtiani, Steven Ballet, Alexander N. Volkov, Jean‐Claude Twizere, Sibusiso B. Maseko   +22 more
wiley   +1 more source

Evaluation of the Therapeutic Effect of Levamisole on Subclinical Mastitis in Bovine Leukemia Virus-Infected Cows Classified by Proviral Load. [PDF]

Animals (Basel)
Watanabe A, Maeda Y, Murakami H, Miyoshi S, Miura M, Murao K, Shinozuka Y, Kurumisawa T, Kawai K.   +8 more
europepmc   +1 more source

Toll‐Like Receptors in the Immunotherapy Era: Dual‐Edged Swords of Tumor Immunity and Clinical Translation

MedComm, Volume 6, Issue 8, August 2025.
This review discussed the signaling pathways of Toll‐like receptors in tumors and their antitumor or protumor regulatory effects in diverse tumors. We also paid attention to the application of Toll‐like receptors in clinical treatment and summarized the clinical trial situation in recent years.
Nueraili Maihemuti, Yueli Shi, Kaiyue Zhang, Xinyuan Jiang, Jiahe Chu, Yun Xu, Zhiyong Xu, Kai Wang   +7 more
wiley   +1 more source

Serological and Molecular Evidence of Bovine Leukemia Virus in Sheep Populations in the South of Iran. [PDF]

Vet Med Sci
Yektaseresht A, Ghane M, Kargar R, Golvajouei MS.   +3 more
europepmc   +1 more source

Advances in the Study of Pluripotent Stem Cells in Livestock

Cell Proliferation, Volume 58, Issue 8, August 2025.
Livestock pluripotent stem cells include embryonic stem cells (ESCs) isolated from the inner cell mass of blastocysts and induced pluripotent stem cells (iPSCs) derived from somatic cell reprogramming. They hold significant potential for applications in livestock breed improvement, rapid propagation, human disease modelling and human organ ...
Xinyi Zhou, Chen Gao, Wenxuan Zhao, Xinhua Wei, Dawei Yu, Huiying Zou, Weihua Du   +6 more
wiley   +1 more source