Results 41 to 50 of about 5,249,730 (235)

Novel immunotherapeutic options for BCG‐unresponsive high‐risk non‐muscle‐invasive bladder cancer

Cancer Medicine, Volume 12, Issue 24, Page 21944-21968, December 2023., 2023
There are limited therapeutic options for BCG‐unresponsive patients with non‐muscle‐invasive bladder cancer. The development of long‐term bladder‐preserving therapies is a significant unmet need for these patients. This article summarizes the current landscape of Immunotherapeutic options beyond immune checkpoint blockers for BCG‐unresponsive, high ...
Zein Alabdin Hannouneh, Amjad Hijazi, Alaa Aldeen Alsaleem, Siwan Hami, Nina Kheyrbek, Fadi Tanous, Karam Khaddour, Abdulfattah Abbas, Zuheir Alshehabi   +8 more
wiley   +1 more source

Clinical guidance of pyoderma gangrenosum 2022

The Journal of Dermatology, Volume 50, Issue 9, Page e253-e275, September 2023., 2023
Abstract Pyoderma gangrenosum (PG) is a rare, neutrophilic skin disease. For the purpose of accurate diagnosis and proper treatment of PG, the Japanese clinical practice guidance for PG developed by the Japanese Dermatological Association was published in 2022.
Toshiyuki Yamamoto, Kenshi Yamasaki, Keiichi Yamanaka, Mayumi Komine, Tamihiro Kawakami, Osamu Yamamoto, Takuro Kanekura, Tetsuya Higuchi, Toshiya Takahashi, Yoshiaki Matsushima, Nobuyuki Kikuchi, Japanese Dermatological Association Pyoderma Gangrenosum Treatment Guidelines Drafting Committee   +11 more
wiley   +1 more source

Sandwich‐Structured Implants to Obstruct Multipath Energy Supply and Trigger Self‐Enhanced Hypoxia‐Initiated Chemotherapy Against Postsurgical Tumor Recurrence and Metastasis

Advanced Science, Volume 10, Issue 22, August 4, 2023., 2023
A dual‐drug‐loaded sandwich‐structured implant is developed to inhibit postsurgical tumor recurrence and metastasis. Combretastatin A4 phosphate (CA4P), preferentially released from 3D‐printed outer layers, obstructs extracellular energy supply, and aggravates hypoxia.
Youqiang Fang, Xing Luo, Yanteng Xu, Zheng Liu, Rachel L. Mintz, Haiyang Yu, Xuan Yu, Kai Li, Enguo Ju, Haixia Wang, Zhaohui Tang, Yu Tao, Mingqiang Li   +12 more
wiley   +1 more source

Leukemoid reaction in a patient with acute lymphoblastic leukemia following the [PDF]

, 2013
The occurrence of persistent neutrophilic leukocytosisabove 50,000 cells/μL for reasons other thanleukemia is defined as leukemoid reaction.
Aynur Albayrak, Habip Gedik, Murat Albayrak, Osman Yokuş   +3 more
core   +1 more source

Tissue culture of spleen : Studies on the growing pattern and its evaluation for clinical diagnosis of leukemias and other hematologic disorders [PDF]

, 1963
It has been found that the clinical tissue culture method devised in our laboratory for bone marrow is satisfactorily applicable to the in vitro study of human and animal splenic tissues.
Hanazawa, Atsumasa, Hiraki, Kiyoshi, Kibata, Masayoshi, Kitajima, Koichi, Miyoshi, Isao, Ofuji, Tadashi, Ota, Zensuke, Shinagawa, Koji, Sunami, Hiroshi   +8 more
core   +1 more source

An unusual response to 5‐azacitidine by a patient with chronic myelomonocytic leukemia

Clinical Case Reports, Volume 11, Issue 8, August 2023., 2023
Bone marrow aspirate smear showing myeloid hyperplasia with blast cells and prominent nucleoli. Key Clinical Message Hypomethylating agents may be useful in some but not all cases of myelodysplastic syndromes. In some versions of these conditions, this treatment may yield deleterious results.
Anwarul Islam
wiley   +1 more source

Cryptococcus, Pathological observations of five autopsy cases and one biopsy case [PDF]

, 1959
Pathologic, anatomical, and histological findings of 5 autopsy cases and one biopsy case of cryptococcosis have been described. Macroscopically the foci of the lung are grayish white or yellowish white in color and range in size from the small acinous ...
Inohara, Tsuyoshi, Kanamoto, Akihisa, Kuroda, Kiyoshi, Murase, Joji, Ogawa, Katsuo, Uejima, Akira   +5 more
core   +1 more source

Fulminant leukemoid reaction due to postpartum Clostridium sordellii infection

Journal of Global Infectious Diseases, 2012
Clostridium sordellii is gram positive anaerobic spore forming rod and it has been demonstrated to cause gas gangrene, refractory shock, leukemoid reaction, and pleuroperitoneal effusion due to capillary leak.
Prabhat Agrawal, Ruchika Garg
doaj   +1 more source

Leukemoid Reaction: Presentation of Two Cases [PDF]

, 2017
The leukemoid reaction is defined by the presence in peripheral blood of white cells above 50,000/mm3 or neutrophils above 30,000/mm3 . The frequency varies between 1.3 and 15% of newborns admitted to neonatal intensive care units [1]. It usually appears
Arca Díaz, Gemma, Botet Mussons, Francisco, Habimana Jordana, N Anna   +2 more
core   +1 more source

Gallotannin-rich Caesalpinia spinosa fraction decreases the primary tumor and factors associated with poor prognosis in a murine breast cancer model [PDF]

, 2013
BACKGROUND: Several treatment alternatives are available for primary breast cancer, although those for metastatic disease or inflammation associated with tumor progression are ineffective. Therefore, there is a great need for new therapeutic alternatives
Alejandra Gomez, Alexzander Asea, Claudia Urueña, Diana Castañeda, John Hernandez, Juan Mancipe, Luis Pombo, Susana Fiorentino   +7 more
core   +1 more source