Results 31 to 40 of about 5,538 (172)
MicroorganismsStaphylococcus aureus (S. aureus) is a prominent Gram-positive bacterial pathogen that expresses numerous cytotoxins known to target human polymorphonuclear leukocytes (PMNs or neutrophils).
Tyler K. Nygaard +7 more
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mBio, 2016 Staphylococcus aureus is a formidable human pathogen that uses secreted cytolytic factors to injure immune cells and promote infection of its host. Of these proteins, the bicomponent family of pore-forming leukocidins play critical roles in S.
Divya Balasubramanian +11 more
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Journal of Medical Case Reports, 2012 Introduction Strains of Panton-Valentine leukocidin-producing Staphylococcus aureus producing a new pattern of disease have emerged worldwide. Infection with these bacteria typically presents as a life-threatening infection of soft tissues and bones, and
Ceroni Dimitri +6 more
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Role of defensins in immunothrombosis
Rheumatology &Autoimmunity, EarlyView.Defensins are important proteins that link the immune system and blood clotting, playing a key role in immunothrombosis. α‐defensins mainly come from neutrophils, while β‐defensins are produced by epithelial cells and platelets. These proteins help form blood clots in several ways: they slow down clot breakdown (fibrinolysis), activate platelets, and ...
Yuebing Wang +7 more
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Journal of Medical Case Reports, 2011 Introduction Certain Staphylococcus aureus strains produce Panton-Valentine leukocidin, a toxin that lyses white blood cells causing extensive tissue necrosis and chronic, recurrent or severe infection.
Rao AV +5 more
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The FASEB Journal, Volume 40, Issue 11, 15 June 2026.L‐malic acid, a natural TCA cycle intermediate, attenuates the virulence of Staphylococcus aureus through dual metabolic and regulatory mechanisms. It redirects central carbon flux away from the mevalonate pathway and inhibits the key enzyme CrtO, suppressing staphyloxanthin biosynthesis and impairing bacterial resistance to oxidative stress ...
Li Shen +11 more
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Prevalence of Genes Encoding Bi-Component Leukocidins among Clinical Isolates of Methicillin–Resistant Staphylococcus aureus [PDF]
Iranian Journal of Public Health, 2010 Background: Staphylococcus aureus has been recognized as a major human pathogen and is the major cause of nosocomial infections. Gamma-toxin, leukocidin and other bi-component toxins are a family of proteins encoded by the hlg and luk-PV, respectively ...
SA Havaei +3 more
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Panton-Valentine Leukocidin–Secreting Staphylococcus aureus Pneumonia Complicating COVID-19
Emerging Infectious Diseases, 2020 Necrotizing pneumonia induced by Panton-Valentine leukocidin–secreting Staphylococcus aureus is a rare but life-threatening infection that has been described in patients after they had influenza.
Claire Duployez +7 more
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The cell envelope of Staphylococcus aureus selectively controls the sorting of virulence factors
Nature Communications, 2021 The pathogen Staphylococcus aureus releases several pore-forming toxins, termed leukocidins, that kill immune cells. Here, Zheng et al. show that the retention of a leukocidin on bacterial cells and its release are modulated by lipoteichoic acid and a ...
Xuhui Zheng +6 more
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Programmed Cell Death in Chronic Rhinosinusitis
Clinical and Translational Allergy, Volume 16, Issue 6, June 2026.ABSTRACT Chronic rhinosinusitis (CRS) is a prevalent upper respiratory condition characterized by a multifaceted etiology involving various cellular and molecular processes. In recent years, researchers have increasingly recognized the significance of different forms of programmed cell death (PCD), such as apoptosis and pyroptosis, in the pathological ...
Xingchen Liu +5 more
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