Results 11 to 20 of about 548,284 (288)

Does Pioglitazone Lead to Neutrophil Extracellular Traps Formation in Chronic Granulomatous Disease Patients?

Frontiers in Immunology, 2019
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, the enzyme complex responsible for reactive oxygen species (ROS) production, is defective in chronic granulomatous disease (CGD) patients.
Gouri P. Hule, Umair Ahmed Bargir, Manasi Kulkarni, Priyanka Kambli, Prasad Taur, Mukesh Desai, Manisha Rajan Madkaikar   +6 more
doaj   +1 more source

An Experimental Model of Bronchopulmonary Dysplasia Features Long-Term Retinal and Pulmonary Defects but Not Sustained Lung Inflammation

Frontiers in Pediatrics, 2021
Bronchopulmonary dysplasia (BPD) is a severe lung disease that affects preterm infants receiving oxygen therapy. No standardized, clinically-relevant BPD model exists, hampering efforts to understand and treat this disease.
Lakshanie C. Wickramasinghe, Peter van Wijngaarden, Peter van Wijngaarden, Chad Johnson, Evelyn Tsantikos, Margaret L. Hibbs   +5 more
doaj   +1 more source

The effect of lipopolysaccharide extracted from Escherichia coli on total WBCs, granulocytes and on phagocytic activity in female rats [PDF]

Iraqi Journal of Veterinary Sciences, 2022
The present study was conducted to compare the total white blood cells count, granulocytes and phagocytic activity in female rats immunized with lipopolysaccharide (LPS) extracted from two different isolates of Escherichia coli, one normal isolate from ...
Aziz T. Koro, Adeba Y. Sharif
doaj   +1 more source

Clinical, Immunological, and Molecular Findings in Five Patients with Major Histocompatibility Complex Class II Deficiency from India

Frontiers in Immunology, 2018
Major histocompatibility complex (MHC) class II deficiency is a rare autosomal recessive form of primary immunodeficiency disorder (PID) characterized by the deficiency of MHC class II molecules.
Jahnavi Aluri, Maya Gupta, Aparna Dalvi, Snehal Mhatre, Manasi Kulkarni, Gouri Hule, Mukesh Desai, Nitin Shah, Prasad Taur, Ramprasad Vedam, Manisha Madkaikar   +10 more
doaj   +1 more source

Healthy Gut, Healthy Bones: Targeting the Gut Microbiome to Promote Bone Health

Frontiers in Endocrinology, 2021
Over the past decade, the use of probiotics to modify the gut microbiome has become a public spotlight in reducing the severity of a number of chronic diseases such as autoimmune disease, diabetes, cancer and cardiovascular disease.
Olivia D. Cooney, Olivia D. Cooney, Prabhakar R. Nagareddy, Andrew J. Murphy, Andrew J. Murphy, Andrew J. Murphy, Man K. S. Lee, Man K. S. Lee, Man K. S. Lee   +8 more
doaj   +1 more source

Fat for fuel: lipid metabolism in haematopoiesis

Clinical & Translational Immunology, 2019
The importance of metabolic regulation in the immune system has launched back into the limelight in recent years. Various metabolic pathways have been examined in the context of their contribution to maintaining immune cell homeostasis and function ...
Gerard Pernes, Michelle C Flynn, Graeme I Lancaster, Andrew J Murphy   +3 more
doaj   +1 more source

Targeted next-generation sequencing revealed a novel homozygous mutation in the LRBA gene causes severe haemolysis associated with Inborn Errors of Immunity in an Indian family.

Hematology, 2022
Objectives LPS-responsive beige-like anchor protein (LRBA) deficiency abolishes LRBA protein expression due to biallelic mutations in the LRBA gene that lead to autoimmune manifestations, inflammatory bowel disease, hypogammaglobulinemia in early stages,
Prabhakar Kedar, Rashmi Dongerdiye, Shanmukhaiah Chandrakala, Umair Ahmed Bargir, Manisha Madkaikar   +4 more
doaj   +1 more source

Natural Killer Cell Degranulation Defect: A Cause for Impaired NK-Cell Cytotoxicity and Hyperinflammation in Fanconi Anemia Patients

Frontiers in Immunology, 2019
Fanconi anemia (FA) is a rare inherited syndrome characterized by progressive bone marrow failure (BMF), abnormal skin pigmentation, short stature, and increased cancer risk. BMF in FA is multifactorial and largely results from the death of hematopoietic
Snehal Shabrish, Madhura Kelkar, Niranjan Chavan, Mukesh Desai, Umair Bargir, Maya Gupta, Priti Mehta, Akanksha Chichra, Chandrakala S, Prasad Taur, Vinay Saxena, Babu Rao Vundinti, Manisha Madkaikar   +12 more
doaj   +1 more source

Phenotyping of Leukocytes and Leukocyte-Derived Extracellular Vesicles [PDF]

Journal of Immunology Research, 2016
Extracellular vesicles (EVs) have a demonstrated involvement in modulating the immune system. It has been proposed that EVs could be used as biomarkers for detection of inflammatory and immunological disorders. Consequently, it is of great interest to investigate EVs in more detail with focus on immunological markers.
Pugholm, Lotte Hatting, Bæk, Rikke, Søndergaard, Evo Kristina Lindersson, Revenfeld, Anne Louise Schacht, Jørgensen, Malene Møller, Varming, Kim   +5 more
openaire   +4 more sources

A role for Rap2 in recycling the extended conformation of LFA-1 during T cell migration

Biology Open, 2012
Summary T lymphocytes make use of their major integrin LFA-1 to migrate on surfaces that express ICAM-1 such as blood vessels and inflamed tissue sites.
Paula Stanley, Sharon Tooze, Nancy Hogg
doaj   +1 more source