Results 241 to 250 of about 933,022 (336)

NDRG1‐Driven Lactate Accumulation Promotes Lung Adenocarcinoma Progression Through the Induction of an Immunosuppressive Microenvironment

Advanced Science, EarlyView.
NDRG1 drives lactate accumulation and histone lactylation in lung adenocarcinoma, promoting immunosuppression via M2 macrophage polarization and CD8⁺ T cell inhibition. High NDRG1 expression correlates with poor prognosis, an immunosuppressive microenvironment, and immunotherapy resistance.
Gujie Wu, Hongxia Cheng, Jiacheng Yin, Yuansheng Zheng, Haochun Shi, Binyang Pan, Ming Li, Mengnan Zhao, Jiaqi Liang, Yunyi Bian, Guangyao Shan, Guoshu Bi, Weigang Guo, Lin Wang, Yiwei Huang   +14 more
wiley   +1 more source

Blood platelet reduction after elexacaftor/tezacaftor/ivacaftor treatment in people with cystic fibrosis may depend on systemic inflammation reduction. [PDF]

Sci Rep
Castaldo A, Cimbalo C, Fevola C, Carnovale V, Iacotucci P, Raia V, Terlizzi V, Gelzo M, Sepe A, Tosco A.   +9 more
europepmc   +1 more source

Engineered Probiotic‐Powered Micro‐Rod Robot Bomb for Thrombus‐Penetrating Explosion

Advanced Science, EarlyView.
For thrombotic diseases with narrow therapeutic windows and persistent vascular damage; existing thrombolytic drugs are difficult to achieve precise; timely; and sustained thrombolytic effects. Here an engineered probiotic driven micro‐rod robot for targeted and penetrative treatment for thrombus is developed.
Riyue Liu, Jiale Chen, Yuanyuan Li, Nawsherwan, Cuilian Dai, Yan Wang, Jinrong Zheng, Kecheng Zhou, Mangmang Sang   +8 more
wiley   +1 more source

CXCL16/CXCR6 axis arises as a potential peripheral biomarker of early COPD development - results from a pilot study. [PDF]

Front Med (Lausanne)
Marques P, Bocigas I, Domingo E, Francisco V, Tarrasó J, Piqueras L, Signes-Costa J, González C, Sanz MJ.   +8 more
europepmc   +1 more source

Remodeling the Physicochemical and Pharmacokinetic Properties of PROTAC via Lipid Nanodisks for Cancer Therapy

Advanced Science, EarlyView.
To solve the challenge of PROTACs in clinical potential due to poor water solubility and membrane permeability, a nanodelivery system based on lipid nanodisks loaded with MZ1 prodrug (LND‐MZ1) to remodel the physicochemical and pharmacokinetic properties of PROTAC MZ1 is elaborately proposed.
Meichen Pan, Chunrong Yang, Zhongliang Fu, Yuchen Yang, Ying Zhuo, Hongwei Hou, Jinghong Li   +6 more
wiley   +1 more source

Type 2 diabetes abates retrograde collateral flow and promotes leukocyte adhesion following ischemic stroke. [PDF]

J Cereb Blood Flow Metab
Sato Y, Kato Y, Kanoke A, Sun JY, Nishijima Y, Wang RK, Stryker M, Endo H, Liu J.   +8 more
europepmc   +1 more source

Leukocytes and Interferon in the Host Response to Viral Infections II. Enhanced Interferon Response of Leukocytes from Immune Animals

, 1966
Lowell A. Glasgow
openalex   +1 more source

[Immunology of leukocytes].

Arquivos brasileiros de medicina, 2003
openaire   +3 more sources

Coactosin‐Like Protein Reduces Prostaglandin D2 Production in Alveolar Macrophages and Alleviates Allergic Airway Inflammation

Advanced Science, EarlyView.
Coactosin‐like protein inhibits prostaglandin D₂ (PGD2) secretion by modulating alveolar macrophage polarization, thereby suppressing activation of the PGD2 receptor CRTH2 in Th2‐associated immune cells and alleviating allergic airway inflammation.
Li‐Long Pan, Zhengnan Ren, Binbin Li, Wenjie Liang, Yang Luo, Qin Yang, He Liu, Xiaoliang Dong, Haizhi Tian, Huimin Zou, Bengt Samuelsson, Olof Rådmark, Jia Sun   +12 more
wiley   +1 more source

The Re-Emergence of Pediatric Pertussis: Insights from a Regional Romanian Hospital. [PDF]

Antibiotics (Basel)
Rosca I, Turenschi A, Dinulescu A, Lichii V.   +3 more
europepmc   +1 more source