Results 111 to 120 of about 765,746 (286)

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

open access: yesAdvanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang   +8 more
wiley   +1 more source

Leukocyte count and aggregation during the evolution of cerebral ischemic injury

open access: yes, 1998
We evaluated leukocyte aggregation by means of the leukergy test and count in 26 patients with atherothrombotic stroke and in 10 patients with transient ischemic attacks.
Piccolo, P   +7 more
core   +2 more sources

Thymosin Alpha‐1 Provides Direct Neuroprotection by Engaging the Orexin Receptor HCRTR1 to Suppress Neuronal Necroptosis

open access: yesAdvanced Science, EarlyView.
In this study, we unveil a thymus‐brain endocrine axis wherein Tα1 engages HCRTR1 to inhibit RIPK3‐mediated necroptosis. This study nominates the Tal‐HCRTR1‐RIPK3 axis as a potent and clinically translatable therapeutic target for stroke and neurodegeneration.
Xinmei Kang   +11 more
wiley   +1 more source

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

open access: yesAdvanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang   +11 more
wiley   +1 more source

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

open access: yesAdvanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li   +14 more
wiley   +1 more source

Altered leukocyte blood count in COVID-19 pandemic period

open access: yesИнфекция и иммунитет
Relevance. A potential for zoonotic transmission of highly pathogenic coronavirus strains to humans was of little concern to health care providers, which came as a surprise and led to a coronavirus pandemic in 2020 spring.
Sergey N. Kostarev, T. G. Sereda
doaj   +1 more source

Effect of anticoagulants on leukocyte count and viability.

open access: yes, 2014
Leukocytes were isolated from sodium-heparin- and EDTA whole blood samples followed by analysis of cell viability and count. Values are represented as mean ± SE of two independent experiments.Effect of anticoagulants on leukocyte count and viability.
Nikolai Siebert (630387)   +4 more
core   +1 more source

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

open access: yesAdvanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao   +7 more
wiley   +1 more source

The effects of diazinon on haematological indices and LC50 (96h) of Acipenser nudiventris

open access: yes‬‭Majallah-i ̒Ilmī-i Shīlāt-i Īrān, 2005
We treated 150 specimens of Acipenser nudiventris with diazinon and used 30 individuals as control to assess the haematological effects of the pesticide and LC50(96h) for the fish.
H. Khoshbavar rostami1; M. Soltani2
doaj  

The development during the experiment of leukocyte count, platelet count and hemoglobin.

open access: yes, 2013
Values are given as relative to the baseline value in percent. Mean ± SE, (n = 18). Baseline values: Leukocyte count 10.6±1.0 109×L−1, Platelet count 380±29 109×L−1, Hemoglobin 76±2 g×L−1.
Markus Castegren (289782)   +4 more
core   +1 more source

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