Results 131 to 140 of about 183,293 (251)

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3–IFI6 Circuit in Breast Cancer

Advanced Science, EarlyView.
SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu, Yuhan Tang, Yingcui Chen, Zhuoqi Zhang, Yige Lu, Xinyue Wang, Qiyuan Shi, Wenhui Zhao, Hui Pang   +8 more
wiley   +1 more source

Can leukocyte count predict the presence of post-traumatic lesions on the WBCT in clinically stable severe trauma patients? A retrospective study. [PDF]

BMC Emerg Med
Grau-Mercier L, Boclaud P, Ajavon F, Coisy F, Grandpierre RG, Frandon J, Bobbia X.   +6 more
europepmc   +1 more source

An Integrated DNA Nanoprobe for Intranuclear Imaging and in Situ Profiling of OGG1 Activity

Advanced Science, EarlyView.
The TP‐SA nanoprobe, integrating an AS1411 aptamer for nuclear delivery and a FRET array for signal amplification, enables real‐time tracking of nuclear OGG1 activity. It reveals cell‐line‐specific basal OGG1 levels and shows clinical promise using pneumonia patients’ lavage fluid.
Mingzhu Zhao, Xuemei Sun, He Li, Bangming Wang, Mengting Pan, Zhen Ma, Rong‐Mei Kong, Weiheng Kong, Yan Zhao, Fengli Qu   +9 more
wiley   +1 more source

Genetic Determinants of Leukocyte Count in Nonsyndromic Cleft Lip With or Without Cleft Palate Among Asians. [PDF]

Int Dent J
Xing C, Lou S, Gao Y, Li X, Du M, Pan Y.
europepmc   +1 more source

Effect of interleukin-1 blockade with anakinra on leukocyte count in patients with ST-segment elevation acute myocardial infarction. [PDF]

Sci Rep, 2022
Del Buono MG, Damonte JI, Trankle CR, Kadariya D, Carbone S, Thomas G, Turlington J, Markley R, Canada JM, Biondi-Zoccai GG, Kontos MC, Van Tassell BW, Abbate A.   +12 more
europepmc   +1 more source

An Edible Biohybrid Platform Accomplishes In Situ Fenton‐Mediated Enteral Nanoplastics Aging and Excretion

Advanced Science, EarlyView.
An edible biohybrid platform triggers nanoplastics (NPs) aging and agglomeration by in situ generating hydroxyl radicals within the intestine. The enlarged NPs are unable to penetrate the intestine and are subsequently excreted. Simultaneously, probiotic biofilms reinforce the intestinal barrier.
Su Zhou, Anran Yan, Haowei Guo, Ping Chen, Qiang Chu   +4 more
wiley   +1 more source

Association of Differential Leukocyte Count With Incident Abdominal Aortic Aneurysm Over 22.5 Years: The ARIC Study. [PDF]

Arterioscler Thromb Vasc Biol, 2021
Parikh RR, Folsom AR, Poudel K, Lutsey PL, Demmer RT, Pankow JS, Chen LY, Tang W.   +7 more
europepmc   +1 more source

A Dual‐Phase Exosomal Nanotherapy Enhances Continual Efferocytosis by Coordinating Checkpoint Inhibition and Metabolic Reprogramming in Atherosclerosis

Advanced Science, EarlyView.
Here we developed Am@SExo, a dual‐functional engineered exosome that coordinates CD47–SIRPα checkpoint blockade with Arg1 mRNA–mediated metabolic reprogramming. Surface SIRPα promotes recognition of apoptotic cells and plaque targeting, while Arg1 expression enhances arginine–ornithine metabolism, Rac1 activation, and actin remodeling in macrophages ...
Danwen Zheng, Shiteng Cai, Jinfeng Gao, Sheng Zhao, Bohan Wei, Xueyi Weng, Zhengmin Wang, Qiaozi Wang, Qiyu Li, Chengzhi Han, Weiyan Li, Yiwen Tan, Yuyuan Fu, Meng Ji, Zheyong Huang, Yanan Song, Juying Qian, Junbo Ge   +17 more
wiley   +1 more source

Leukocyte Count and Risks of Stroke and Coronary Heart Disease: The Circulatory Risk in Communities Study (CIRCS). [PDF]

J Atheroscler Thromb, 2022
Li J, Imano H, Yamagishi K, Tanaka M, Cui R, Muraki I, Umesawa M, Hayama-Terada M, Ohira T, Kiyama M, Okada T, Sankai T, Tanigawa T, Kitamura A, Iso H.   +14 more
europepmc   +1 more source