Results 151 to 160 of about 765,746 (286)

Cobalt Single‐Atom Nanozyme for Enhanced Intestinal Radioprotection and Tumor Radiosensitization via Bidirectional ROS Modulation

Advanced Science, EarlyView.
Orally administered, pH‐responsive Co‐SAN exerts dual functions: in the alkaline intestinal milieu, it scavenges reactive oxygen species (ROS) and suppresses the PI3K/AKT pathway and NETs formation, thus providing radioprotection; whereas in the acidic tumor microenvironment, it generates ROS and alleviates hypoxia, thereby enhancing radiosensitization.
Shengqi Yin, Junjie Li, Yishu Zou, Yang Liu, Yilin Zheng, Lu Yu, Wanying Zheng, Yajun Zou, Zehui Zhang, Tao Li, Peiqun Yin, Jianlin Zhang, Yuen Wu, Yi Ding   +13 more
wiley   +1 more source

Association of leukocyte count with death in people with HIV: A longitudinal study over 24 years. [PDF]

PLoS One
Klein Z, Meyer SC, Schoepf IC, Weber M, Thorball CW, Ryom L, Kootstra NA, Reiss P, Braun DL, Thurnheer MC, Marzolini C, Kahlert CR, Bernasconi E, Cavassini M, Marinosci A, Fellay J, Kouyos RD, Günthard HF, Ledergerber B, Tarr PE, and the Swiss HIV Cohort Study.   +20 more
europepmc   +1 more source

Pretreatment Leukocyte Count Ratios as Metastatic Predictive Factors in Luminal Type Breast Cancer. [PDF]

Asian Pac J Cancer Prev, 2022
Wira Wiguna IGW, Indrani Remitha NPS, Sadvika IGAS, Wiranata S, Putra IWAS, Adiputra PAT, Supadmanaba IGP, Wihandani DM.   +7 more
europepmc   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

Leukocyte count and new-onset diabetes mellitus in people with HIV: A longitudinal study. [PDF]

HIV Med
Meyer SC, Klein Z, Schoepf IC, Thorball CW, Labarile M, Kootstra NA, Reiss P, Ryom L, Braun DL, Thurnheer MC, Marzolini C, Kahlert CR, Bernasconi E, Cavassini M, Marinosci A, Fellay J, Günthard HF, Kouyos RD, Ledergerber B, Tarr PE, Swiss HIV Cohort Study.   +20 more
europepmc   +1 more source

Higher Leukocyte Count Is Associated with Lower Presence of Carotid Lipid-Rich Necrotic Core: A Sub-Study in the Plaque at RISK (PARISK) Study. [PDF]

J Clin Med, 2023
van Velzen TJ, Stolp J, van Dam-Nolen D, Kassem M, Hendrikse J, Kooi ME, Bos D, Nederkoorn PJ.   +7 more
europepmc   +1 more source

Risk of Inflammatory Bowel Disease Following Hospital‐Treated Infections and Modulatory Role of Host Genetics to Support a Multi‐Hit Pathogenesis Model

Advanced Science, EarlyView.
Hospital‐treated infections are linked to increased risk of inflammatory bowel disease in a large prospective cohort. This risk differs by infection burden, time since infection, and host immune‐genetic susceptibility. The findings support a multi‐hit pathogenesis model in which severe infection and inherited susceptibility jointly shape inflammatory ...
Haiming Zhuang, Lintao Dan, Xin Xiang, Xixian Ruan, Shuai Yuan, Jialu Yao, Jiawei Geng, Jonas F. Ludvigsson, Tian Fu, Candida Abreu, Laurent Peyrin‐Biroulet, Xue Li, Yi Xiao, Fernando Magro, Xiaoyan Wang, Jing Sun, Jie Chen   +16 more
wiley   +1 more source

The Association of Fall Mechanism, Leukocyte Count, and Glucose Level With Undesirable Outcomes in Patients With Blunt Trauma Intracranial Hemorrhage: A Retrospective Study. [PDF]

Cureus
Dunham CM, Huang GS.
europepmc   +1 more source

Dietary L-Carnitine Affects Leukocyte Count and Function in Dairy Cows Around Parturition. [PDF]

Front Immunol, 2022
Kononov SU, Meyer J, Frahm J, Kersten S, Kluess J, Bühler S, Wegerich A, Rehage J, Meyer U, Huber K, Dänicke S.   +10 more
europepmc   +1 more source

Microenvironment‐Responsive Nanomedicine Enables Vertical Modulation of Mitochondrial Pathological Networks in Myocardial Ischemia–Reperfusion Injury

Advanced Science, EarlyView.
A mitochondria‐targeted, microenvironment‐responsive nanoplatform enables pH/ROS‐triggered co‐delivery of berberine and isoliensinine to orchestrate ROS scavenging, inflammation suppression, and apoptosis inhibition. This vertical modulation of mitochondrial pathological networks preserves mitochondrial function and effectively mitigates myocardial ...
Jue Wang, Jia Zhou, Wenqin Yuan, Tianjiao Zhao, Yunying Huang, Yingci Xia, Yuting Lin, Fei Li, Qiong Huang, Chong Liu, Kelong Ai, Qun Qin   +11 more
wiley   +1 more source