Results 221 to 230 of about 237,141 (361)

Genome‐Wide Aggregated Trans Effects Analysis Identifies Genes Encoding Immune Checkpoints as Core Genes for Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective The sparse effector “omnigenic” hypothesis postulates that the polygenic effects of common single nucleotide polymorphisms (SNPs) on a typical complex trait are mediated by trans effects that coalesce on expression of a relatively sparse set of core genes.
Athina Spiliopoulou, Andrii Iakovliev, Darren Plant, Megan Sutcliffe, Seema Sharma, Cankut Cubuk, Myles Lewis, Costantino Pitzalis, Anne Barton, Paul M. McKeigue   +9 more
wiley   +1 more source

Expert Perspectives on a Clinical Challenge: Hematologic Malignancies and Vasculitis

Arthritis &Rheumatology, Accepted Article.
Systemic vasculitis describes a collection of rare diseases each caused by inflammation of blood vessel walls that can cause severe systemic complications [[3, 4]](#ref‐0003). The pattern of vascular inflammation and resultant damage is frequently variable and may be mimicked, or directly triggered, by infection or malignancy.
Michelle L. Robinette, Hetty E. Carraway
wiley   +1 more source

Long donor leukocyte telomeres raise risk of severe COVID-19 in recipients of allogeneic hematopoietic cell transplant. [PDF]

Front Immunol
Mendez KJW, Lai TP, Spellman SR, Verhulst S, Anderson J, Saber W, Gadalla SM, Aviv A.   +7 more
europepmc   +1 more source

Childhood Trauma Associated with Short Leukocyte Telomere Length in Posttraumatic Stress Disorder [PDF]

, 2011
Aoife O’Donovan, Elissa S. Epel, Jue Lin, Owen M. Wolkowitz, Beth E. Cohen, Shira Maguen, Thomas J. Metzler, Maryann Lenoci, Elizabeth H. Blackburn, Thomas C. Neylan   +9 more
openalex   +1 more source

Paradoxical Activation of Entheseal Myeloid Cells by JAK1 and TYK2 Inhibitors via IL10 Antagonism

Arthritis &Rheumatology, Accepted Article.
Background JAK inhibition (JAKi) is effective in seronegative spondyloarthropathy (SpA) spectrum disorders, but TYK2 inhibition failed in SpA spectrum ulcerative colitis, and tofacitinib showed minimal benefit in Crohn's Disease, which highlights the complex role for JAK‐STAT signaling in different inflammatory processes. In this study, we investigated
Sami Giryes, Chi Wong, Charlie Bridgewood, Mark Harland, Ala Altaie, Nicole McDermott, Kerem Abacar, Abhay Rao, Almas Khan, Tristan McMillan, Peter Loughenbery, Robert Dunsmuir, Vishal Borse, Tom Macleod, Dennis McGonagle   +14 more
wiley   +1 more source

Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis

Hepatology, EarlyView., 2022
Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo, Ivana Nikolic, Alfonso Mora, Elena Rodríguez, Luis Leiva‐Vega, Aránzazu Pintor‐Chocano, Daniel Horrillo, Lourdes Hernández‐Cosido, Jorge L. Torres, Eva Novoa, Rubén Nogueiras, Gema Medina‐Gómez, Miguel Marcos, Magdalena Leiva, Guadalupe Sabio   +14 more
wiley   +1 more source

Heparin-Binding Protein in Cerebrospinal Fluid as a Biomarker for Bacterial Meningitis: A Study of Diagnostic Accuracy. [PDF]

Ann Neurol
Olie SE, Staal SL, da Cruz Campos AC, Bodilsen J, Nielsen H, van de Beek D, Brouwer MC.   +6 more
europepmc   +1 more source

Gout and NLRP3 inflammasome biology

Arthritis &Rheumatology, Accepted Article.
This review describes the three broad stages of acute inflammation in the context of gout: initiation, leucocyte mobilisation, and self‐resolution. A typical case of a gout flare is presented. The role of the NLRP3 inflammasome in acute monosodium urate crystal‐induced inflammation is reviewed in detail.
Raewyn Poulsen, Nicola Dalbeth
wiley   +1 more source

Human Leukocyte Antigen Haplotypes Predisposing to Celiac Disease in Patients With Endometriosis. [PDF]

Am J Reprod Immunol
Vannuccini S, Manzi V, Tarocchi M, Donati N, La Torre F, Toscano F, Calabrò AS, Petraglia F.   +7 more
europepmc   +1 more source

Analyzing leukocyte telomere length in bipolar disorder: Authors’ reply [PDF]

Revista Brasileira de Psiquiatria, 2017
Michael Berk, Michael Berk, Gabriel Rodrigo Fries, Flávio Kapczinski, Lucas Kich Grun, Bruna Panizzutti, Adriane R. Rosa, Mariana Migliorini Parisi, Florencia María Barbé-Tuana, Fátima T. Guma, Clarissa Severino Gama   +10 more
openaire   +5 more sources