Results 341 to 350 of about 237,141 (361)

Leukocyte telomerase activity and antidepressant efficacy in bipolar disorder

European Neuropsychopharmacology, 2014
Telomeres are DNA-protein complexes that cap linear DNA strands, protecting DNA from damage. Recently, shorten telomeres length has been reported in bipolar disorder (BD) and depression. The enzyme telomerase regulates telomeres׳ length, which has been associated with cellular viability; however it is not clear how telomerase may be involved in the ...
Márcio Gerhardt Soeiro-de-Souza, Ricardo Alberto Moreno, Marcus V. Zanetti, Julia F. Bezerra, Antônio Lúcio Teixeira, Wagner F. Gattaz, Flávia Rodrigues, Elvis Cueva Mateo, Rodrigo Machado-Vieira, Rodrigo Machado-Vieira, Vanessa de Jesus Rodrigues de Paula   +10 more
openaire   +3 more sources

Physiological Roles of Leukocytes and Disorders

2018
This chapter describes white blood cells of the peripheral blood: neutrophils, eosinophils, basophils, monocytes, and lymphocyte subsets. It describes their basic physiology and important disease states associated with defects of each of these entities. Each of these cells arises from a common bone marrow myeloid or lymphoid progenitor to differentiate
Evi X. Stavrou, Evi X. Stavrou, Alex Yee-Chen Huang, Alex Yee-Chen Huang, Jahnavi Gollamudi   +4 more
openaire   +2 more sources

Cyclic-AMP production by polymorphonuclear leukocytes in psychiatric disorders

Biological Psychiatry, 1989
The cyclic adenosine monophosphate (cAMP) responses to histamine, prostaglandin-E1, and isoproterenol in polymorphonuclear leukocytes from drug-free normal controls and patients with schizophrenia or major depressive disorder were compared. These three groups of subjects did not differ in their cAMP responses to receptor activation.
Celeste A. Johns, Michael H. Davidson, Emil F. Coccaro, Philip D. Kanof, Larry J. Siever, Kenneth L. Davis, Kenneth L. Davis   +6 more
openaire   +3 more sources

Human Leukocyte Antigen Type and Posttransplant Lymphoproliferative Disorder

Transplantation, 2015
Posttransplant lymphoproliferative disorder (PTLD) is an infrequent but serious complication of solid organ transplantation. Early detection and initiation of therapy may improve outcomes. The purpose of this study was to identify human leukocyte antigen (HLA) type as risk and prognostic factors for PTLD.A review was undertaken to identify PTLD cases ...
Ronald P. Pelletier, Stanley I. Martin, Mark E. Lustberg, Susan Geyer, Carl Quinion, Pierluigi Porcu, Robert A. Baiocchi, Michael A. Caligiuri   +7 more
openaire   +3 more sources

Leukocyte mitochondrial DNA copy number in bipolar disorder

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2014
Evidence supports the role for mitochondrial impairment in the pathophysiology of bipolar disorder (BD). BD has been associated with decreased mitochondrial electron transport chain activity and increased oxidative stress. Also, mitochondrial DNA (mtDNA) encodes mitochondrial electron transport chain proteins and has been associated with altered ...
Sueli Mieko Oba Shinjo, Wagner F. Gattaz, Sueli K.N. Marie, Miyuki Uno, Geraldo F. Busatto, Rafael T. de Sousa, Marcus V. Zanetti, Rodrigo Machado-Vieira   +7 more
openaire   +2 more sources

Altered arachidonate metabolism by leukocytes and platelets in myeloproliferative disorders

Prostaglandins, Leukotrienes and Medicine, 1983
The arachidonate metabolism by leukocytes and platelets was studied in 14 patients with myeloproliferative disorders including 7 patients with chronic myeloid leukemia (CML), 5 with polycythemia vera (PV) and 2 with essential thrombocythemia (ET).
Hiroshi Takayama, Shigeki Sensaki, Minoru Okuma, Kenji Kanaji, Tateo Sugiyama, Haruto Uchino   +5 more
openaire   +3 more sources

WHIM syndrome: a genetic disorder of leukocyte trafficking

Current Opinion in Allergy and Clinical Immunology, 2003
WHIM syndrome (the association of warts, hypogammaglobulinemia, recurrent bacterial infections, and 'myelokathexis') is a rare congenital form of neutropenia associated with an unusual immune disorder involving hypogammaglonulinemia and abnormal susceptibility to warts.
openaire   +2 more sources

Leukocyte telomere length is reduced in patients with major depressive disorder

Drug Development Research, 2019
AbstractMajor depressive disorder (MDD) is a chronic, severe psychiatric illness with an incidence of 3% worldwide. MDD patients have a significantly impaired quality of life and reduced life expectancy compared to unaffected individuals, the latter being largely accounted for by an increased incidence of suicide and cardiovascular disorders.
Maria Skokou, Konstantinos Assimakopoulos, Evangelia-Eirini Tsermpini, Dimitrios Balasopoulos, Donatella Congiu, Claudia Pisanu, Alessio Squassina, Zoe Kordou, Anna Meloni, George P. Patrinos, George P. Patrinos, Philippos Gourzis   +11 more
openaire   +3 more sources

Telomere shortening in blood leukocytes of patients with posttraumatic stress disorder

Journal of Psychiatric Research, 2019
Telomeres are protective fragments on chromosome ends involved in maintaining genome stability, preventing chromosomal fusions, regulation of cell division. It was shown that telomere attrition rate is accelerated in age-related diseases, as well as in response to physiological and psychosocial stress.
Arsen Arakelyan, Arsen Arakelyan, Diana Avetyan, Diana Avetyan, Martin Petrek, Roksana Zakharyan   +5 more
openaire   +3 more sources

Radial segmentation of leukocyte nuclei in some rheumatic disorders

Rheumatology International, 1994
Heat-induced radial segmentation of leukocyte nuclei is a phenomenon reported to occur in various inflammatory diseases. In order to explore its potential diagnostic value, we studied the occurrence of this phenomenon in 32 subjects with rheumatic inflammatory diseases, 14 subjects with noninflammatory disease, and 15 healthy individuals.
P. Core, Claudio Cervini, S. Muti
openaire   +2 more sources