Results 51 to 60 of about 237,141 (361)

BAFF Index and CXCL13 levels in the cerebrospinal fluid associate respectively with intrathecal IgG synthesis and cortical atrophy in multiple sclerosis at clinical onset [PDF]

, 2017
Background B lymphocytes are thought to play a relevant role in multiple sclerosis (MS) pathology. The in vivo analysis of intrathecally produced B cell-related cytokines may help to clarify the mechanisms of B cell recruitment and ...
Ermani, M., Federle, L., Gallo, P., Miante, S., Perini, P., Poggiali, D., Pravato, S., Puthenparampil, M., Rinaldi, F., Ruggero, S., Toffanin, E., Zito, Alberto   +11 more
core   +1 more source

BENZENE EXPOSURE ANALYSIS IN INFORMAL SHOE INDUSTRY WORKERS IN SUKAJAYA VILLAGE, WEST JAVA VIA LEUKOCYTE COUNT AND S-PHENYLMERCAPTURIC ACID MEASUREMENT IN URINE

Public Health of Indonesia, 2019
Background: Benzene is a hematotoxic and carcinogenic compound contained in the glue used in the shoe industry. This compound has been suspected of causing decreased leukocyte counts, which is one of the blood cell production disorders.
Lora Agustina, Ririn Arminsih Wulandari
doaj   +1 more source

Monocytosis in the acute phase of SARS-CoV-2 infection predicts the presence of anosognosia for cognitive deficits in the chronic phase

Brain, Behavior, & Immunity - Health, 2022
Reduced awareness of neuropsychological disorders (i.e., anosognosia) is a striking symptom of post-COVID-19 condition. Some leukocyte markers in the acute phase may predict the presence of anosognosia in the chronic phase, but they have not yet been ...
A. Nuber-Champier, P. Voruz, I. Jacot de Alcântara, G. Breville, G. Allali, P.H. Lalive, F. Assal, J.A. Péron   +7 more
doaj  

Autism & Gluten: The Proof By Regression!

Pediatric Neurology Briefs, 2018
Investigators from different clinical and research centers from Paris, France studied the polymorphisms of the HLA class II loci in an autistic population.
Hakim Rahmoune, Nada Boutrid
doaj   +1 more source

Inflammatory polyradiculoneuropathies: Clinical and immunological aspects, current therapies, and future perspectives

European Journal of Inflammation, 2020
Inflammatory polyradiculoneuropathies are heterogeneous disorders characterized by immune-mediated leukocyte infiltration of peripheral nerves and nerve roots leading to demyelination or axonal degeneration or both.
Vincenzo Di Stefano, Filomena Barbone, Camilla Ferrante, Roberta Telese, Michela Vitale, Marco Onofrj, Antonio Di Muzio   +6 more
doaj   +1 more source

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Leukocyte telomere shortening in Huntington's disease [PDF]

, 2019
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by an expanded CAG repeat. Though symptom onset commonly occurs at midlife and inversely correlates with the CAG repeat expansion, age at clinical onset and progression ...
Corbo, Rm., Frontali, M, Mantuano, E, Peconi, M, Scarabino, D, Veneziano, L   +5 more
core   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Regulatory Effects of Curcumin on Platelets: An Update and Future Directions

Biomedicines, 2022
The rhizomatous plant turmeric, which is frequently used as a spice and coloring ingredient, yields curcumin, a bioactive compound. Curcumin inhibits platelet activation and aggregation and improves platelet count.
Yaseen Hussain, Abdullah, Fazlullah Khan, Khalaf F. Alsharif, Khalid J. Alzahrani, Luciano Saso, Haroon Khan   +6 more
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source