Results 31 to 40 of about 77,224 (268)

Influence of polyamines of bacterial origin on the production of key cytokines in the culture of human mononuclear leukocytes

Медицинская иммунология, 2022
To date, participation of biogenic polyamines has been studied in details, with respect to regulation of microbial gene expression, interrelations between bacteria, development of their persistence state.
A. P. Godovalov, T. I. Karpunina
doaj   +1 more source

Isolation of Infiltrating Leukocytes from the Spinal Cord of Mice

Bio-Protocol, 2013
The infiltration of leukocytes into the central nervous system (CNS) is a common feature of many neuroinflammatory diseases such as multiple sclerosis, and also occurs during certain microbial infections such as by West Nile Virus.
Julia Martinez Gomez, Stephan Gasser, Herbert Schwarz   +2 more
doaj   +1 more source

Immunological response of human leucocytes after exposure to lipopolysaccharides from Porphyromonas gingivalis

Clinical and Experimental Dental Research, 2021
Porphyromonas gingivalis (P. gingivalis) is a gram‐negative bacterium and an important etiologic agent of periodontitis. P. gingivalis releases outer membrane vesicles containing lipopolysaccharides (LPS), which can penetrate periodontal tissues. Once in
Sara Alizadehgharib, Anna‐Karin Östberg, Agnes Dahlstrand Rudin, Ulf Dahlgren, Karin Christenson   +4 more
doaj   +1 more source

LEPTIN AS AN INDUCER OF INFLAMMATION AND OXIDATIVE STRESS BY METABOLIC SYNDROME

Бюллетень сибирской медицины, 2014
Object of research: to explore the relationship of leptin level in blood serum with markers of systemic inflammation and spontaneous production of cytokines and reactive oxygen species by blood mononuclear leukocytes at metabolic syndrome.Material and ...
I. D. Bespalovа
doaj   +1 more source

An Altered Metabolism in Leukocytes Showing in vitro igG Memory From SARS-CoV-2-Infected Patients

Frontiers in Molecular Biosciences, 2022
Coronavirus disease 2019 (COVID 19) is a systemic infection that exerts a significant impact on cell metabolism. In this study we performed metabolomic profiling of 41 in vitro cultures of peripheral blood mononuclear cells (PBMC), 17 of which displayed ...
G. Fanelli, F. Gevi, G. Zarletti, M. Tiberi, V. De Molfetta, G. Scapigliati, A. M. Timperio   +6 more
doaj   +1 more source

Down-regulation of cholesterol biosynthesis in sitosterolemia: diminished activities of acetoacetyl-CoA thiolase, 3-hydroxy-3-methylglutaryl-CoA synthase, reductase, squalene synthase, and 7-dehydrocholesterol Δ7-reductase in liver and mononuclear leukocytes

Journal of Lipid Research, 1998
Sitosterolemia is a recessively inherited disorder characterized by abnormally increased plasma and tissue plant sterol concentrations. Patients have markedly reduced whole body cholesterol biosynthesis associated with suppressed hepatic, ileal, and ...
Akira Honda, Gerald Salen, Lien B. Nguyen, G. Stephen Tint, Ashok K. Batta, Sarah Shefer   +5 more
doaj   +1 more source

Secretome Profiling of Atlantic Salmon Head Kidney Leukocytes Highlights the Role of Phagocytes in the Immune Response to Soluble β-Glucan

Frontiers in Immunology, 2021
β‐Glucans (BG) are glucose polymers which are produced in bacteria and fungi but not in vertebrate organisms. Being recognized by phagocytic leukocytes including macrophages and neutrophils through receptors such as dectin-1 and Complement receptor 3 ...
Dimitar B. Iliev, Dimitar B. Iliev, Guro Strandskog, Mehrdad Sobhkhez, Jack A. Bruun, Jorunn B. Jørgensen   +5 more
doaj   +1 more source

Cryopreservation of Human Mucosal Leukocytes. [PDF]

PLoS ONE, 2016
BACKGROUND:Understanding how leukocytes in the cervicovaginal and colorectal mucosae respond to pathogens, and how medical interventions affect these responses, is important for developing better tools to prevent HIV and other sexually transmitted ...
Sean M Hughes, Zhiquan Shu, Claire N Levy, April L Ferre, Heather Hartig, Cifeng Fang, Gretchen Lentz, Michael Fialkow, Anna C Kirby, Kristina M Adams Waldorf, Ronald S Veazey, Anja Germann, Hagen von Briesen, M Juliana McElrath, Charlene S Dezzutti, Elizabeth Sinclair, Chris A R Baker, Barbara L Shacklett, Dayong Gao, Florian Hladik   +19 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Polyomaviruses BK and JC DNA infection in peripheral blood cells from blood donors

Brazilian Journal of Infectious Diseases, 2019
Objectives: To investigate the prevalence of human polyomavirus (BK and JC viruses) infection in peripheral blood mononuclear cells of healthy blood donors. Methods: The study included 250 healthy blood donors.
Malihe Fathi Haghighi, Noorossadat Seyyedi, Ali Farhadi, Farahnaz Zare, Leila Kasraian, Gholam Reza Refiei Dehbidi, Reza Ranjbaran, Abbas Behzad-Behbahani   +7 more
doaj   +1 more source