Results 31 to 40 of about 9,864 (178)

Study of Caspase 8 mutation in oral cancer and adjacent precancer tissues and implication in progression.

PLoS ONE, 2020
It is hypothesized that same driver gene mutations should be present in both oral leukoplakia and cancer tissues. So, we attempted to find out mutations at one of the driver genes, CASP8, in cancer and adjacent leukoplakia tissues.
Richa Singh, Shreya Das, Sila Datta, Anjana Mazumdar, Nidhan K Biswas, Arindam Maitra, Partha P Majumder, Sandip Ghose, Bidyut Roy   +8 more
doaj   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Demographic and clinicopathological comparison among oral lichen planus, lichenoid lesions and proliferative verrucous leukoplakia: a retrospective study

BMC Oral Health
Background Clinicopathological diagnosis and follow-up of oral lichen planus and leukoplakia are necessary due to its potential for malignant transformation and the need to differentiate it from other lichenoid diseases and proliferative verrucous ...
Milena Duarte Moreira, Fernanda Doyle Maia, Viviane Limongi Zimbrão, Emilly Collodetti, Tânia Regina Grão-Velloso, Liliana Aparecida Pimenta-Barros, Simone de Queiroz Chaves Lourenço, Danielle Resende Camisasca   +7 more
doaj   +1 more source

A quantitative expression of Ki-67 to evaluate malignant transformation rate in potentially malignant disorders

Journal of Dr. NTR University of Health Sciences, 2018
Objective: To evaluate the quantitative expression of Ki-67 in oral leukoplakia, oral submucous fibrosis (OSF) and to compare their expression with normal oral epithelium.
Mani D Chitipothu, Kiran K Kattappagari, Divyasri Godavarthy, Chandrashekar Poosarla, Sridhar R Gountu, Venkata R. R. Baddam   +5 more
doaj   +1 more source

Oral Squamous Cell Carcinoma‐Risk Factors, Diagnosis, Treatment, and Prevention

Cancer Nexus, EarlyView.
ABSTRACT Oral squamous cell carcinoma (OSCC) usually originates from the precancerous lesions of oral mucosa and accounts for approximately 90% of oral cancers. In‐depth understanding of pathogenesis, hallmarks, and etiological factors is a crucial prerequisite for advancing the diagnosis and treatment for OSCC patients. This review aims to present the
Liping Wang, Xiaole Liu, Mengjie Chen, Ying Hu, Lilei Zhu   +4 more
wiley   +1 more source

Greater Attention to Gingival Cancer and Floor of Mouth Cancer: Based on a Retrospective Analysis of Oral Cancer Across Different Subsites

Head &Neck, EarlyView.
ABSTRACT Background The gingiva and floor of the mouth are distinct subsites, and oral squamous cell carcinoma (OSCC) originating in these locations warrants further indepth understanding. Methods This study enrolled patients with OSCC from 2000 to 2020, and analyzed the clinicopathological characteristics.
Hao Li, Yi Ding, Yansheng Wu, Yan Fang, Xinhua Li, Weifeng Shi, Shaoshi Chen, Ailin Yang, Jin Zhang, Ruoyu Shi, Chao Jing, Xudong Wang, Yuansheng Duan   +12 more
wiley   +1 more source

Correlation of PD-1 and PD-L1 expression in oral leukoplakia and oral squamous cell carcinoma: an immunohistochemical study

Scientific Reports, 2023
The programmed cell death protein (PD-1)/programmed cell death protein ligand (PD-L1) pathway and cytotoxic T lymphocyte antigen are the most important co-stimulatory molecules that play a key role in the negative regulation of T cells during ...
L. R. Greeshma, Anna P. Joseph, T. T. Sivakumar, Varun Raghavan Pillai, Gopikrishnan Vijayakumar   +4 more
doaj   +1 more source

Malignant Transformation of Oral Epithelial Dysplasia in Southern Finland

Head &Neck, EarlyView.
ABSTRACT Background Oral epithelial dysplasia (OED) often precedes oral squamous cell carcinoma (OSCC). The aim was to elucidate the risk and time of malignant transformation (MT) of OED. Methods Patients diagnosed with OED between 2001 and 2011 in Helsinki and Uusimaa, Finland were included.
Katariina Leino, Hanna K. Laine, Ville Kinnula, Jaana Rautava   +3 more
wiley   +1 more source

Multi‐Institutional Assessment of Dental Students' Knowledge in Oral Soft Tissue Pathological Entities

Journal of Dental Education, EarlyView.
ABSTRACT Objectives This study provides a descriptive, multi‐institutional comparison of dental students' recognition accuracy and management decisions of oral soft tissue pathological entities across four US dental schools. While prior single‐institution studies have evaluated diagnostic ability, this work provides a multi‐institutional comparison to ...
Nicole McKee, Paul Edwards, Gerardo Maupomé, George Eckert, Celine Joyce Cornelius Timothius, Karim El Kholy, Jennifer Chang, Vanchit John   +7 more
wiley   +1 more source

Oral leukoplakia: Transmission electron microscopic correlation with clinical types and light microscopy

Dental Research Journal, 2012
Background: Leukoplakia, is a precancerous lesion that is most commonly encountered in the oral cavity. The grade of dysplasia is presumed to be the most important indicator of malignant potential. There are many promising aspects in advanced methods for
Sandhya Avinash Tamgadge, Sindhu Milind Ganvir, Vinay Krishnarao Hazarey, Avinash Tamgadge   +3 more
doaj   +1 more source