Results 141 to 150 of about 2,921 (175)
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Anaerobe, 2008
Liver abscesses in cattle are associated primarily with Fusobacterium necrophorum, a gram negative, pleomorphic, and obligate anaerobe. In cattle, the organism is a normal inhabitant of the rumen and an opportunistic pathogen. There are two subspecies: subsp. necrophorum and subsp. funduliforme. Subspecies necrophorum is more frequently isolated, often
T G Nagaraja +2 more
exaly +3 more sources
Liver abscesses in cattle are associated primarily with Fusobacterium necrophorum, a gram negative, pleomorphic, and obligate anaerobe. In cattle, the organism is a normal inhabitant of the rumen and an opportunistic pathogen. There are two subspecies: subsp. necrophorum and subsp. funduliforme. Subspecies necrophorum is more frequently isolated, often
T G Nagaraja +2 more
exaly +3 more sources
American Journal of Respiratory Cell and Molecular Biology, 2001
Abstract Leukotoxin is clinically associated with acute respiratory distress syndrome (ARDS). Recently, we found that leukotoxin-diol, the hydrated product of leukotoxin, is more toxic than the parent leukotoxin in vitro (Moghaddam and colleagues, Nature Med. 1997;3:562–566).
Jiang Zheng +4 more
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Abstract Leukotoxin is clinically associated with acute respiratory distress syndrome (ARDS). Recently, we found that leukotoxin-diol, the hydrated product of leukotoxin, is more toxic than the parent leukotoxin in vitro (Moghaddam and colleagues, Nature Med. 1997;3:562–566).
Jiang Zheng +4 more
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American Journal of Veterinary Research, 1986
SUMMARY Sterile, concentrated culture supernatant from Pasteurella haemolytica (biotype A, serotype 1) strain 630 was subjected to physical, chemical, and immunologic treatments to determine their influence on leukotoxin (cytotoxin) activity contained in the supernatant.
Y F, Chang, H W, Renshaw, A B, Richards
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SUMMARY Sterile, concentrated culture supernatant from Pasteurella haemolytica (biotype A, serotype 1) strain 630 was subjected to physical, chemical, and immunologic treatments to determine their influence on leukotoxin (cytotoxin) activity contained in the supernatant.
Y F, Chang, H W, Renshaw, A B, Richards
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Leukotoxins of gram-negative bacteria
Veterinary Microbiology, 2002Leukotoxins are a group of exotoxins that produce their primary toxic effects against leukocytes, especially polymorphonuclear cells (PMNs). Leukotoxins include a variety of chemicals ranging from 9,10-epoxy 12-octadecenoate, a fatty acid derivative secreted by leukocytes themselves, to proteins such as RTX (repeats in toxin).
Sanjeev Kumar, Narayanan +3 more
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Isolation of Pasteurella haemolytica leukotoxin mutants
Infection and Immunity, 1995Two mutants of Pasteurella haemolytica A1 that do not produce leukotoxin were isolated. Following mutagenesis, colonies were screened with antiserum by a filter assay for absence of the secreted leukotoxin. The two mutants both appeared to produce normal amounts of other antigens, as judged by reactivity with polyclonal serum from an animal with ...
M, Chidambaram +5 more
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Hemolytic activity of the Pasteurella haemolytica leukotoxin
Infection and Immunity, 1995A Pasteurella haemolytica mutant incapable of producing leukotoxin was created by allelic replacement. Concentrated culture supernatants from wild-type P. haemolytica, but not from the mutant, contained the 102-kDa leukotoxin protein and lysed bovine lymphoma cells and sheep erythrocytes. Wild-type P. haemolytica demonstrated the typical beta-hemolytic
G L, Murphy +3 more
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Nihon Kyobu Shikkan Gakkai zasshi, 1991
It is well known that pulmonary influx of neutrophils is involved in lung injury in patients with adult respiratory distress syndrome (ARDS). Neutrophils are major contributors to the self-defence mechanism, however, adverse effects of neutrophils have also been recognized. Recently, we found that a highly toxic substance, 9, 10-epoxy-12-octadecenoate (
T, Ozawa +3 more
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It is well known that pulmonary influx of neutrophils is involved in lung injury in patients with adult respiratory distress syndrome (ARDS). Neutrophils are major contributors to the self-defence mechanism, however, adverse effects of neutrophils have also been recognized. Recently, we found that a highly toxic substance, 9, 10-epoxy-12-octadecenoate (
T, Ozawa +3 more
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LEUKOTOXIN PRODUCTION BY ACTINOBACILLUS ACTINOMYCETEMCOMITANS
Toxin Reviews, 2006Actinobacillus actinomycetemcomitans is a gram-negative pathogen that causes human severe periodontitis. The most intensively studied virulence factor of this bacterium is a pore-forming cytotoxin termed leukotoxin. Production of leukotoxin varies considerably among A. actinomycetemcomitans strains.
Tetsuyoshi Inoue +2 more
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Mannheimia haemolytica leukotoxin
2010Mannheimia haemolytica is the primary bacterial pathogen of bovine pneumonic pasteurellosis, an economically important disease of cattle worldwide. Leukotoxin (Lkt) produced by M. haemolytica is the major virulence factor of this organism. The cytolytic activity of Lkt is specific for ruminant leukocytes.
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Binding of Pasteurella haemolytica leukotoxin to bovine leukocytes
Infection and Immunity, 1997Pasteurella haemolytica is the principal bacterial pathogen in the bovine respiratory disease complex. This organism produces an exotoxin (referred to as leukotoxin) during logarithmic-phase growth that is a potent leukocyte-modulating agent. At low concentrations, it activates neutrophils and mononuclear phagocytes to release inflammatory mediators ...
J F, Brown, F, Leite, C J, Czuprynski
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