Results 1 to 10 of about 3,428 (189)

The cytolethal distending toxin contributes to microbial virulence and disease pathogenesis by acting as a tri-perditious toxin

Frontiers in Cellular and Infection Microbiology, 2016
This review summarizes the current status and recent advances in our understanding of the role that the cytolethal distending toxin (Cdt) plays as a virulence factor in promoting disease by toxin-producing pathogens.
Monika D Scuron, Kathleen Boesze-Battaglia, Mensur Dlakic, Bruce J Shenker   +3 more
doaj   +1 more source

Internalization of the Active Subunit of the Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin Is Dependent upon Cellugyrin (Synaptogyrin 2), a Host Cell Non-Neuronal Paralog of the Synaptic Vesicle Protein, Synaptogyrin 1

Frontiers in Cellular and Infection Microbiology, 2017
The Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) is a heterotrimeric AB2 toxin capable of inducing lymphocytes, and other cell types, to undergo cell cycle arrest and apoptosis.
Kathleen Boesze-Battaglia, Lisa P. Walker, Anuradha Dhingra, Konstantin Kandror, Hsin-Yao Tang, Bruce J. Shenker   +5 more
doaj   +1 more source

A plasmid-mediated type III secretion system associated with invasiveness and diarrheagenicity of Providencia rustigianii

mBio
We have recently described a clinical isolate of Providencia rustigianii strain JH-1 carrying the genes for cytolethal distending toxin (CDT) in a conjugative plasmid.
Jayedul Hassan, Atsushi Hinenoya, Noritoshi Hatanaka, Sharda Prasad Awasthi, Goutham Belagula Manjunath, Nahid Rahman, Jyoji Yamate, Shota Nakamura, Daisuke Motooka, Akira Nagita, Shah M. Faruque, Shinji Yamasaki   +11 more
doaj   +1 more source

Bacterial Toxin Modulation of the Eukaryotic Cell Cycle: Are all Cytolethal Distending Toxins Created Equally?

Frontiers in Cellular and Infection Microbiology, 2012
The cytolethal distending toxins (CDTs) comprise a family of intracellular-acting bacterial protein toxins whose actions upon eukaryotic cells result in several consequences, the most characteristic of which is the induction of G2/M cell cycle arrest ...
Amandeep eGargi, Michael eReno, Steven R Blanke   +2 more
doaj   +1 more source

Genotoxicity of Cytolethal Distending Toxin (CDT) on isogenic human colorectal cell lines: potential promoting effects for colorectal carcinogenesis

Frontiers in Cellular and Infection Microbiology, 2016
The composition of the human microbiota influences tumorigenesis, notably in colorectal cancer (CRC). Pathogenic Escherichia coli possesses a variety of virulent factors, among them the Cytolethal Distending Toxin (CDT).
Vanessa eGraillot, Inge eDormoy, Jacques eDupuy, Jerry eShay, Laurence eHuc, Gladys eMirey, Julien eVignard   +6 more
doaj   +1 more source

The Cytolethal Distending Toxin Subunit CdtB of Helicobacter hepaticus Promotes Senescence and Endoreplication in Xenograft Mouse Models of Hepatic and Intestinal Cell Lines

Frontiers in Cellular and Infection Microbiology, 2017
Cytolethal distending toxins (CDTs) are common among pathogenic bacteria of the human and animal microbiota. CDTs exert cytopathic effets, via their active CdtB subunit.
Christelle Péré-Védrenne, Christelle Péré-Védrenne, Martina Prochazkova-Carlotti, Martina Prochazkova-Carlotti, Benoit Rousseau, Wencan He, Wencan He, Lucie Chambonnier, Lucie Chambonnier, Elodie Sifré, Elodie Sifré, Alice Buissonnière, Alice Buissonnière, Pierre Dubus, Pierre Dubus, Pierre Dubus, Francis Mégraud, Francis Mégraud, Christine Varon, Christine Varon, Armelle Ménard, Armelle Ménard   +21 more
doaj   +1 more source

Pathogenicity of the highly leukotoxic JP2 clone of Aggregatibacter actinomycetemcomitans and its geographic dissemination and role in aggressive periodontitis

Journal of Oral Microbiology, 2014
For decades, Aggregatibacter actinomycetemcomitans has been associated with aggressive forms of periodontitis in adolescents. In the middle of the 1990s, a specific JP2 clone of A.
Dorte Haubek, Anders Johansson
doaj   +1 more source

Upregulation of occludin by cytolethal distending toxin facilitates Glaesserella parasuis adhesion to respiratory tract cells. [PDF]

Infect Immun, 2023
Yang Z, Zhang Y, Du S, Zhao Q, Huang X, Wu R, Yan Q, Han X, Cao S, Chang Y-F, Wen Y.   +10 more
europepmc   +1 more source

Host-associated variability of the cdtABC operon, coding for the cytolethal distending toxin, in Campylobacter jejuni. [PDF]

Zoonoses Public Health, 2022
Guirado P, Iglesias-Torrens Y, Miró E, Navarro F, Attolini CS, Balsalobre C, Madrid C.   +6 more
europepmc   +1 more source

Presence of Functionally Active Cytolethal Distending Toxin Genes on a Conjugative Plasmid in a Clinical Isolate of Providencia rustigianii. [PDF]

Infect Immun, 2023
Hassan J, Awasthi SP, Hatanaka N, Hoang PH, Nagita A, Hinenoya A, Faruque SM, Yamasaki S.   +7 more
europepmc   +1 more source