Results 1 to 10 of about 232 (115)
Harnessing the Membrane Translocation Properties of AB Toxins for Therapeutic Applications [PDF]
Toxins, 2021 Over the last few decades, proteins and peptides have become increasingly more common as FDA-approved drugs, despite their inefficient delivery due to their inability to cross the plasma membrane.
Numa Piot +2 more
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Frontiers in Cellular and Infection Microbiology, 2022 Bacterial AB-type toxins are proteins released by the producing bacteria and are the causative agents for several severe diseases including cholera, whooping cough, diphtheria or enteric diseases.
Katharina Ernst
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iScience, 2022 Summary: The development of anti-infectives against a large range of AB-like toxin-producing bacteria includes the identification of compounds disrupting toxin transport through both the endolysosomal and retrograde pathways.
Yu Wu +31 more
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Frontiers in Molecular Biosciences, 2023 Mechanisms of leptospirosis pathogenesis remain unclear despite the identification of a number of potential leptospiral virulence factors. We recently demonstrated potential mechanisms by which the virulence-modifying (VM) proteins—defined as containing ...
Reetika Chaurasia, Joseph M. Vinetz
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Antibody to ricin a chain hinders intracellular routing of toxin and protects cells even after toxin has been internalized. [PDF]
PLoS ONE, 2013 Mechanisms of antibody-mediated neutralization are of much interest. For plant and bacterial A-B toxins, A chain mediates toxicity and B chain binds target cells.
Kejing Song +5 more
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Cytotoxic Effects of Recombinant StxA2-His in the Absence of Its Corresponding B-Subunit
Toxins, 2021 AB5 protein toxins are produced by certain bacterial pathogens and are composed of an enzymatically active A-subunit and a B-subunit pentamer, the latter being responsible for cell receptor recognition, cellular uptake, and transport of the A-subunit ...
Laura Heinisch +4 more
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Cellular Activity of Salmonella Typhimurium ArtAB Toxin and Its Receptor-Binding Subunit
Toxins, 2021 Salmonellosis is among the most reported foodborne illnesses in the United States. The Salmonellaenterica Typhimurium DT104 phage type, which is associated with multidrug-resistant disease in humans and animals, possesses an ADP-ribosylating toxin called
Elise Overgaard +7 more
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Toxins, 2023 Japanese encephalitis virus (JEV) is an enveloped icosahedral capsid virus with a prime neutralizing epitope present in E protein domain III (EDIII). E dimers are rearranged into a five-fold symmetry of icosahedrons. Cholera toxin B (CTB) and heat-labile
Jina Ahn +6 more
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Food and Agricultural Immunology, 2020 Anti-idiotypic antibody technology has been widely developed. Here, we prepared the F(ab’)2 fragments of the Cry1F toxin polyclonal antibody as Ab1and screened an anti-idiotype nanobody (VHH) for Bt Cry1F toxin from the camelid naive antibody phage ...
Jia Hao +9 more
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Sensors, 2010 This study describes the direct detection of the biological toxin (Ricin) in acidic environment without pH adjustment by hydrophobically modified electrochemical impedance immunosensor (EII). The nano-porous aluminum substrate for EII was hydrophobically
Changhoon Chai +2 more
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