Harnessing the Membrane Translocation Properties of AB Toxins for Therapeutic Applications [PDF]
Toxins, 2021 Over the last few decades, proteins and peptides have become increasingly more common as FDA-approved drugs, despite their inefficient delivery due to their inability to cross the plasma membrane.
Numa Piot +2 more
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Antibody to ricin a chain hinders intracellular routing of toxin and protects cells even after toxin has been internalized. [PDF]
PLoS ONE, 2013 Mechanisms of antibody-mediated neutralization are of much interest. For plant and bacterial A-B toxins, A chain mediates toxicity and B chain binds target cells.
Kejing Song +5 more
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Pharmacological inhibition of host cell neddylation reduces intoxication of cells by diphtheria toxin and clostridial enterotoxins TcdB and C2 [PDF]
Microbiology SpectrumNEDD8 is a ubiquitin-like molecule that is conjugated to lysine residues of protein substrates in a process known as neddylation, which affects their stability, degradation, and interactions.
Irina König +4 more
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iScience, 2022 Summary: The development of anti-infectives against a large range of AB-like toxin-producing bacteria includes the identification of compounds disrupting toxin transport through both the endolysosomal and retrograde pathways.
Yu Wu +31 more
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Frontiers in Cellular and Infection Microbiology, 2022 Bacterial AB-type toxins are proteins released by the producing bacteria and are the causative agents for several severe diseases including cholera, whooping cough, diphtheria or enteric diseases.
Katharina Ernst
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The Battle Against Pertussis: Discovery of Endogenous Human Proteins and Peptides as Toxin-Inhibitors [PDF]
ToxinsThe life-threatening disease pertussis, also known as whooping cough, is caused by a complex interplay of several virulence factors produced by the bacterium Bordetella (B.) pertussis.
Stefanie Lietz, Holger Barth
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Deciphering the Emergence of Biofilm-Independent Colistin Persistence and Resistance in A. baumannii: Toxin–Antitoxin Omics and Novel T/A mRNA-asRNA Balance Regulatory Models [PDF]
AntibioticsBackground: Persistence represents a critical evolutionary reservoir for the development of antimicrobial resistance in Acinetobacter baumannii (Ab). Understanding the basal mechanisms that enable this survival strategy is crucial for elucidating how ...
Eleonora Chines +5 more
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Frontiers in Molecular Biosciences, 2023 Mechanisms of leptospirosis pathogenesis remain unclear despite the identification of a number of potential leptospiral virulence factors. We recently demonstrated potential mechanisms by which the virulence-modifying (VM) proteins—defined as containing ...
Reetika Chaurasia, Joseph M. Vinetz
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Cytotoxic Effects of Recombinant StxA2-His in the Absence of Its Corresponding B-Subunit
Toxins, 2021 AB5 protein toxins are produced by certain bacterial pathogens and are composed of an enzymatically active A-subunit and a B-subunit pentamer, the latter being responsible for cell receptor recognition, cellular uptake, and transport of the A-subunit ...
Laura Heinisch +4 more
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Cellular Activity of Salmonella Typhimurium ArtAB Toxin and Its Receptor-Binding Subunit
Toxins, 2021 Salmonellosis is among the most reported foodborne illnesses in the United States. The Salmonellaenterica Typhimurium DT104 phage type, which is associated with multidrug-resistant disease in humans and animals, possesses an ADP-ribosylating toxin called
Elise Overgaard +7 more
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