Results 1 to 10 of about 212,774 (115)

Recombinant HSA-CMG2 Is a Promising Anthrax Toxin Inhibitor [PDF]

Toxins, 2016
Anthrax toxin is the major virulence factor produced by Bacillus anthracis. Protective antigen (PA) is the key component of the toxin and has been confirmed as the main target for the development of toxin inhibitors.
Liangliang Li, Qiang Guo, Ju Liu, Jun Zhang, Ying Yin, Dayong Dong, Ling Fu, Junjie Xu, Wei Chen   +8 more
doaj   +2 more sources

The Battle Against Pertussis: Discovery of Endogenous Human Proteins and Peptides as Toxin-Inhibitors [PDF]

Toxins
The life-threatening disease pertussis, also known as whooping cough, is caused by a complex interplay of several virulence factors produced by the bacterium Bordetella (B.) pertussis.
Stefanie Lietz, Holger Barth
doaj   +2 more sources

Pharmacological inhibition of host cell neddylation reduces intoxication of cells by diphtheria toxin and clostridial enterotoxins TcdB and C2 [PDF]

Microbiology Spectrum
NEDD8 is a ubiquitin-like molecule that is conjugated to lysine residues of protein substrates in a process known as neddylation, which affects their stability, degradation, and interactions.
Irina König, Katharina Oßwald, Lisa Schneider, Holger Barth, Panagiotis Papatheodorou   +4 more
doaj   +2 more sources

A host defense role for Fibrinogen by direct binding of Clostridium botulinum C2 toxin [PDF]

Cellular and Molecular Life Sciences
In addition to fibrinogens canonical function in hemostasis, alternate roles in innate immunity have emerged. However, interactions with bacterial protein toxins, the main virulence factors of many medically relevant bacteria and causative agents of life-
Sophia Kistermann, Sebastian Heber, Stephan Fischer, Jannik Sichau, Christoph Q. Schmidt, Marco Mannes, Markus Huber-Lang, Holger Barth   +7 more
doaj   +2 more sources

Cellular signaling pathway of Shiga toxin-induced ATP release [PDF]

Frontiers in Cellular and Infection Microbiology
BackgroundShiga toxin (Stx) is the main virulence factor of enterohemorrhagic Escherichia coli, a food-borne pathogen that colonizes the intestine causing gastroenteritis and, in severe cases, hemolytic uremic syndrome.
Karl Johansson, Ida Arvidsson, Markus Wendler, Ann-Charlotte Kristoffersson, Diana Karpman   +4 more
doaj   +2 more sources

The Compound U18666A Inhibits the Intoxication of Cells by Clostridioides difficile Toxins TcdA and TcdB

Frontiers in Microbiology, 2021
The intestinal pathogen Clostridioides (C.) difficile is a major cause of diarrhea both in hospitals and outpatient in industrialized countries.
Panagiotis Papatheodorou, Selina Kindig, Adriana Badilla-Lobo, Stephan Fischer, Ebru Durgun, Tharani Thuraisingam, Alexander Witte, Shuo Song, Klaus Aktories, Esteban Chaves-Olarte, César Rodríguez, Holger Barth   +11 more
doaj   +1 more source

Exploring the inhibitory potential of the antiarrhythmic drug amiodarone against Clostridioides difficile toxins TcdA and TcdB

Gut Microbes, 2023
The intestinal pathogen Clostridioides difficile is the leading cause of antibiotic-associated diarrhea and pseudomembranous colitis in humans. The symptoms of C.
Judith Schumacher, Astrid Nienhaus, Sebastian Heber, Jauheni Matylitsky, Esteban Chaves-Olarte, César Rodríguez, Holger Barth, Panagiotis Papatheodorou   +7 more
doaj   +1 more source

Cathepsin Release from Lysosomes Promotes Endocytosis of Clostridium perfringens Iota-Toxin

Toxins, 2021
Iota-toxin from Clostridium perfringens type E is a binary toxin composed of two independent proteins: actin-ADP-ribosylating enzyme component, iota-a (Ia), and binding component, iota-b (Ib).
Masahiro Nagahama, Keiko Kobayashi, Masaya Takehara   +2 more
doaj   +1 more source

Internalization of Clostridium botulinum C2 Toxin Is Regulated by Cathepsin B Released from Lysosomes

Toxins, 2021
Clostridium botulinum C2 toxin is a clostridial binary toxin consisting of actin ADP-ribosyltransferase (C2I) and C2II binding components. Activated C2II (C2IIa) binds to cellular receptors and forms oligomer in membrane rafts.
Masahiro Nagahama, Keiko Kobayashi, Sadayuki Ochi, Masaya Takehara   +3 more
doaj   +1 more source

Delayed toxicity associated with soluble anthrax toxin receptor decoy-Ig fusion protein treatment. [PDF]

PLoS ONE, 2012
Soluble receptor decoy inhibitors, including receptor-immunogloubulin (Ig) fusion proteins, have shown promise as candidate anthrax toxin therapeutics.
Diane Thomas, John Naughton, Christopher Cote, Susan Welkos, Marianne Manchester, John A T Young   +5 more
doaj   +1 more source