Results 11 to 20 of about 209,245 (296)
Cathepsin Release from Lysosomes Promotes Endocytosis of Clostridium perfringens Iota-Toxin
Toxins, 2021 Iota-toxin from Clostridium perfringens type E is a binary toxin composed of two independent proteins: actin-ADP-ribosylating enzyme component, iota-a (Ia), and binding component, iota-b (Ib).
Masahiro Nagahama +2 more
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Eeyarestatin 1 interferes with both retrograde and anterograde intracellular trafficking pathways. [PDF]
PLoS ONE, 2011 The small molecule Eeyarestatin I (ESI) inhibits the endoplasmic reticulum (ER)-cytosol dislocation and subsequent degradation of ERAD (ER associated protein degradation) substrates. Toxins such as ricin and Shiga/Shiga-like toxins (SLTx) are endocytosed
Mina-Olga Aletrari +10 more
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Delayed toxicity associated with soluble anthrax toxin receptor decoy-Ig fusion protein treatment. [PDF]
PLoS ONE, 2012 Soluble receptor decoy inhibitors, including receptor-immunogloubulin (Ig) fusion proteins, have shown promise as candidate anthrax toxin therapeutics.
Diane Thomas +5 more
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Scientific ReportsThe bacterium Clostridium botulinum, well-known for producing botulinum neurotoxins, which cause the severe paralytic illness known as botulism, produces C2 toxin, a binary AB-toxin with ADP-ribosyltranferase activity.
Stefanie Lietz +3 more
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Rational Drug Designing Strategies and Inhibitor Optimization: Anthrax Lethal Toxin Factor [PDF]
International Journal Bioautomation, 2012 Anthrax toxin protein protective antigen, edema factor and lethal factor are secreted by Bacillus anthracis bacteria causes several adverse effects on human as well as on ruminant animals and considered as serious biological weapons. Lethal toxin protein
Pawan Kumar Jayaswal +2 more
doaj +1 more source
Frontiers in Microbiology, 2021 The intestinal pathogen Clostridioides (C.) difficile is a major cause of diarrhea both in hospitals and outpatient in industrialized countries.
Panagiotis Papatheodorou +11 more
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Designing inhibitors of anthrax toxin [PDF]
Expert Opinion on Drug Discovery, 2014 Present-day rational drug design approaches are based on exploiting unique features of the target biomolecules, small- or macromolecule drug candidates and physical forces that govern their interactions. The 2013 Nobel Prize in chemistry awarded 'for the development of multiscale models for complex chemical systems' once again demonstrated the ...
Ekaterina M, Nestorovich +1 more
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Carbohydrate inhibitors of cholera toxin [PDF]
Beilstein Journal of Organic Chemistry, 2018 Cholera is a diarrheal disease caused by a protein toxin released by Vibrio cholera in the host’s intestine. The toxin enters intestinal epithelial cells after binding to specific carbohydrates on the cell surface. Over recent years, considerable effort has been invested in developing inhibitors of toxin adhesion that mimic the carbohydrate ligand ...
Kumar, Vajinder, Turnbull, W Bruce
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Toxins, 2021 Clostridium botulinum C2 toxin is a clostridial binary toxin consisting of actin ADP-ribosyltransferase (C2I) and C2II binding components. Activated C2II (C2IIa) binds to cellular receptors and forms oligomer in membrane rafts.
Masahiro Nagahama +3 more
doaj +1 more source
Human α-Defensin-5 Efficiently Neutralizes Clostridioides difficile Toxins TcdA, TcdB, and CDT
Frontiers in Pharmacology, 2020 Infections with the pathogenic bacterium Clostridioides (C.) difficile are coming more into focus, in particular in hospitalized patients after antibiotic treatment. C. difficile produces the exotoxins TcdA and TcdB.
Michael Korbmacher +5 more
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