Results 41 to 50 of about 209,245 (296)

Multivalent Inhibitors of Channel-Forming Bacterial Toxins [PDF]

, 2016
Rational design of multivalent molecules represents a remarkable modern tool to transform weak non-covalent interactions into strong binding by creating multiple finely-tuned points of contact between multivalent ligands and their supposed multivalent targets. Here, we describe several prominent examples where the multivalent blockers were investigated
Goli, Yamini, Ekaterina M, Nestorovich
openaire   +2 more sources

Tamoxifen blocks retrograde trafficking of Shiga toxin 1 and 2 and protects against lethal toxicosis

Life Science Alliance, 2019
This study reports an unexpected role of late endosome–lysosome fusion in early endosome-to-Golgi trafficking of Shiga toxins and identifies tamoxifen to be a potent inhibitor of Shiga toxicosis. Shiga toxin 1 (STx1) and 2 (STx2), produced by Shiga toxin–
Andrey S Selyunin, Steven Hutchens, Stanton F McHardy, Somshuvra Mukhopadhyay   +3 more
doaj   +1 more source

Identification of small molecule inhibitors of Pseudomonas aeruginosa exoenzyme S using a yeast phenotypic screen. [PDF]

PLoS Genetics, 2008
Pseudomonas aeruginosa is an opportunistic human pathogen that is a key factor in the mortality of cystic fibrosis patients, and infection represents an increased threat for human health worldwide.
Anthony Arnoldo, Jasna Curak, Saranya Kittanakom, Igor Chevelev, Vincent T Lee, Mehdi Sahebol-Amri, Becky Koscik, Lana Ljuma, Peter J Roy, Antonio Bedalov, Guri Giaever, Corey Nislow, A Rod Merrill, Stephen Lory, Igor Stagljar   +14 more
doaj   +1 more source

Killer Toxins of Yeasts: Inhibitors of Fermentation and Their Adsorption

Journal of Food Protection, 1987
The killer toxin (KT 28), a glycoprotein of Saccharomyces cerevisiae strain 28, was almost completely adsorbed by bentonite, when applied at a concentration of 1 g per liter. No significant differences were found between several types of bentonite. Killer toxin KT 28 is similarly adsorbed by intact yeast cells or by a commercial preparation of yeast ...
Ferdinand, Radler, Manfred, Schmitt
openaire   +2 more sources

FcStuA from Fusarium culmorum controls wheat foot and root rot in a toxin dispensable manner [PDF]

, 2013
Fusarium culmorum is one of the most harmful pathogens of durum wheat and is the causal agent of foot and root rot (FRR) disease. F. culmorum produces the mycotoxin deoxynivalenol (DON) that is involved in the pathogenic process.
Kim E Hammond-Kosack, Francesca Spanu (381433), Lucien Hoffmann (381436), Hammond Kosack, Kim E., Barbara Scherm (381434), F. Spanu, M. Beyer, Pasquali, Matias, Lucien Hoffmann, Marco Beyer, Virgilio Balmas (381435), Pasquali, M., Spanu, Francesca, Hoffmann, L., Balmas, V., Spanu, F., Scherm, Barbara, L. Hoffmann, Beyer, M., Balmas, Virgilio, Matias Pasquali (381432), Matias Pasquali, Marco Beyer (381437), Migheli, Quirico, M. Pasquali, Beyer, Marco, Hammond-Kosack, Kim E., K. E. Hammond Kosack, Virgilio Balmas, Hoffmann, Lucien, Barbara Scherm, Hammond-Kosack, K. E., B. Scherm, Q. Migheli, Francesca Spanu, Quirico Migheli (381438), Scherm, B., Quirico Migheli, Kim E. Hammond-Kosack (13913), Migheli, Q., V. Balmas   +40 more
core   +1 more source

Clostridium perfringens Delta-Toxin Damages the Mouse Small Intestine

Toxins, 2019
Clostridium perfringens strains B and C cause fatal intestinal diseases in animals. The secreted pore-forming toxin delta-toxin is one of the virulence factors of the strains, but the mechanism of intestinal pathogenesis is unclear. Here, we investigated
Soshi Seike, Masaya Takehara, Keiko Kobayashi, Masahiro Nagahama   +3 more
doaj   +1 more source

miR-30d Inhibition Protects IPEC-J2 Cells Against Clostridium perfringens Beta2 Toxin-Induced Inflammatory Injury

Frontiers in Veterinary Science, 2022
Clostridium perfringens beta2 (CPB2) toxin, one of the virulence factors of Clostridium perfringens (C. perfringens), can cause necrotizing enterocolitis in piglets. Accumulating pieces of evidence indicate that microRNAs (miRNAs) refer to the regulation
Kaihui Xie, Qiaoli Yang, Zunqiang Yan, Xiaoli Gao, Xiaoyu Huang, Pengfei Wang, Juanli Zhang, Jiaojiao Yang, Jie Li, Shuangbao Gun, Shuangbao Gun   +10 more
doaj   +1 more source

A Protein‐Based Pentavalent Inhibitor of the Cholera Toxin B‐Subunit [PDF]

, 2014
Protein toxins produced by bacteria are the cause of many life-threatening diarrheal diseases. Many of these toxins, including cholera toxin (CT), enter the cell by first binding to glycolipids in the cell membrane.
McAllister, TE, Turnbull, WB, Fascione, MA, Garcia Hartjes, J., Zuilhof, H, Turnbull, W.B., Fascione, M.A., McAllister, T.E., Zuilhof, H., Garcia-Hartjes, J, Wennekes, T., Branson, TR, Wennekes, T, Warriner, S.L., Ross, JF, Branson, T.R., Warriner, SL, Ross, J.F.   +17 more
core   +1 more source

Cellular vacuoles induced by Mycoplasma pneumoniae CARDS toxin originate from Rab9-associated compartments. [PDF]

PLoS ONE, 2011
Recently, we identified an ADP-ribosylating and vacuolating cytotoxin in Mycoplasma pneumoniae designated Community Acquired Respiratory Distress Syndrome (CARDS) toxin.
Coreen Johnson, T R Kannan, Joel B Baseman   +2 more
doaj   +1 more source

Impact of the Introduction of a Two-Step Laboratory Diagnostic Algorithm in the Incidence and Earlier Diagnosis of Clostridioides difficile Infection

Microorganisms, 2022
Our aim was to determine changes in the incidence of CD infection (CDI) following the introduction of a two-step diagnostic algorithm and to analyze CDI cases diagnosed in the study period.
Nieves Sopena, Jun Hao Wang-Wang, Irma Casas, Lourdes Mateu, Laia Castellà, María José García-Quesada, Sara Gutierrez, Josep M. Llibre, M. Luisa Pedro-Botet, Gema Fernandez-Rivas   +9 more
doaj   +1 more source