Results 31 to 40 of about 958,820 (304)

Clostridium perfringens Epsilon-Toxin Impairs the Barrier Function in MDCK Cell Monolayers in a Ca²⁺-Dependent Manner

Toxins, 2020
Epsilon-toxin produced by Clostridium perfringens significantly contributes to the pathogeneses of enterotoxemia in ruminants and multiple sclerosis in humans. Epsilon-toxin forms a heptameric oligomer in the host cell membrane, promoting cell disruption.
Masahiro Nagahama, Soshi Seike, Sadayuki Ochi, Keiko Kobayashi, Masaya Takehara   +4 more
doaj   +1 more source

The association of shiga-like toxin with detergent-resistant membranes is modulated by glucosylceramide and is an essential requirement in the endoplasmic reticulum for a cytotoxic effect [PDF]

, 2006
Receptor-mediated internalization to the endoplasmic reticulum (ER) and subsequent retro-translocation to the cytosol are essential sequential processes required for the productive intoxication of susceptible mammalian cells by Shiga-like toxin-1 (SLTx).
Falguières, T, Platt, Frances M., Platt, Frances, Roberts, LM, Sillence, DJ, Smith, Daniel C., Jarvis, Rosemary M., Lord, JM, Smith, DC, Lord, J. Michael, Roberts, Lynne M., Jarvis, R. M., Sillence, Daniel J., Johannes, Ludger, Falguires, T., Falguières, Thomas, Lord, Mike, Johannes, L, Roberts, L. M. (Lynne M.), Jarvis, RM, Smith, D. C.   +20 more
core   +1 more source

Clostridium perfringensepsilon toxin H149A mutant as a platform for receptor binding studies [PDF]

, 2013
Clostridium perfringens epsilon toxin (Etx) is a pore-forming toxin responsible for a severe and rapidly fatal enterotoxemia of ruminants. The toxin is classified as a category B bioterrorism agent by the U.S.
Titball, R.W., Kokkinidou, Maria C., Richard W. Titball, Bokori-Brown, M., Kokkinidou, M.C., Claire E. Naylor, Fernandes da Costa, S.P., Moss, David S., Titball, Richard W., Monika Bokori‐Brown, Maria C. Kokkinidou, David S. Moss, Basak, Ajit K., Bokori-Brown, Monika, Cole, Ambrose R., Sérgio Fernandes da Costa, Naylor, Claire E., Ambrose R. Cole, Fernandes da Costa, Sérgio P., Christos G. Savva, Ajit K. Basak, Savva, Christos G.   +21 more
core   +1 more source

Shiga Toxin Uptake and Sequestration in Extracellular Vesicles Is Mediated by Its B-Subunit

Toxins, 2020
Shiga toxin (Stx)-stimulated blood cells shed extracellular vesicles (EVs) which can transfer the toxin to the kidneys and lead to hemolytic uremic syndrome.
Annie Willysson, Anne-lie Ståhl, Daniel Gillet, Julien Barbier, Jean-Christophe Cintrat, Valérie Chambon, Anne Billet, Ludger Johannes, Diana Karpman   +8 more
doaj   +1 more source

Molecular Architecture of the Antiophidic Protein DM64 and its Binding Specificity to Myotoxin II From Bothrops asper Venom

Frontiers in Molecular Biosciences, 2022
DM64 is a toxin-neutralizing serum glycoprotein isolated from Didelphis aurita, an ophiophagous marsupial naturally resistant to snake envenomation. This 64 kDa antitoxin targets myotoxic phospholipases A2, which account for most local tissue damage of ...
Barbara S. Soares, Surza Lucia G. Rocha, Viviane A. Bastos, Diogo B. Lima, Paulo C. Carvalho, Fabio C. Gozzo, Borries Demeler, Borries Demeler, Borries Demeler, Tayler L. Williams, Janelle Arnold, Amy Henrickson, Thomas J. D. Jørgensen, Tatiana A. C. B. Souza, Jonas Perales, Richard H. Valente, Bruno Lomonte, Francisco Gomes-Neto, Ana Gisele C. Neves-Ferreira   +18 more
doaj   +1 more source

Release of vasopressin from isolated permeabilized neurosecretory nerve terminals is blocked by the light chain of botulinum A toxin [PDF]

, 1990
The intracellular action on exocytosis of botulinim A toxin and constituent chains was studied using permeabilized isolated nerve endings from the rat neural lobe. The release of the neuropeptide vasopressin was measured by radioimmunoassay.
Weller, U., Nordmann, J. J., Dayanithi, G., Ahnert-Hilger, G., Gratzl, Manfred   +4 more
core   +1 more source

Tamoxifen blocks retrograde trafficking of Shiga toxin 1 and 2 and protects against lethal toxicosis

Life Science Alliance, 2019
This study reports an unexpected role of late endosome–lysosome fusion in early endosome-to-Golgi trafficking of Shiga toxins and identifies tamoxifen to be a potent inhibitor of Shiga toxicosis. Shiga toxin 1 (STx1) and 2 (STx2), produced by Shiga toxin–
Andrey S Selyunin, Steven Hutchens, Stanton F McHardy, Somshuvra Mukhopadhyay   +3 more
doaj   +1 more source

Pinpointing anthrax-toxin inhibitors

Nature Biotechnology, 2002
Anthrax toxin consists of three components: protective antigen (PA), lethal factor (LF), and edema factor (EF). Individually, they are nontoxic.
Glick, Meir, Grant, Guy H., Richards, W. Graham   +2 more
openaire   +2 more sources

Comparative genomics of Shiga toxin encoding bacteriophages [PDF]

, 2012
Background Stx bacteriophages are responsible for driving the dissemination of Stx toxin genes (stx) across their bacterial host range. Lysogens carrying Stx phages can cause severe, lifethreatening disease and Stx toxin is an integral virulence factor.
Alan J McCarthy, Darby Alistair C, Alistair C Darby, Allison Heather E, Rooks David J, Rooks, David, Smith, Darren, Paul CM Fogg, Thomson, Nicholas, David J Rooks, Smith Darren L, McCarthy Alan J, McCarthy, Alan, Heather E Allison, Darren L Smith, Allison, Heather, Fogg Paul CM, Nick R Thomson, Fogg, Paul, Darby, Alistair, Thomson Nick R   +20 more
core   +1 more source

Identification of small molecule inhibitors of Pseudomonas aeruginosa exoenzyme S using a yeast phenotypic screen. [PDF]

PLoS Genetics, 2008
Pseudomonas aeruginosa is an opportunistic human pathogen that is a key factor in the mortality of cystic fibrosis patients, and infection represents an increased threat for human health worldwide.
Anthony Arnoldo, Jasna Curak, Saranya Kittanakom, Igor Chevelev, Vincent T Lee, Mehdi Sahebol-Amri, Becky Koscik, Lana Ljuma, Peter J Roy, Antonio Bedalov, Guri Giaever, Corey Nislow, A Rod Merrill, Stephen Lory, Igor Stagljar   +14 more
doaj   +1 more source