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Shiga Toxin: Expression, Distribution, and Its Role in the Environment

Toxins, 2011
In this review, we highlight recent work that has increased our understanding of the production and distribution of Shiga toxin in the environment. Specifically, we review studies that offer an expanded view of environmental reservoirs for Shiga toxin ...
Koudelka Gerald B
exaly   +4 more sources

The Effect of Mitomycin C on Induction of Shiga Toxin Production in Clinical STEC Isolates [PDF]

Toxins
Early determination of the Shiga toxin type of Shiga toxin-producing Escherichia coli (STEC) is crucial for guiding STEC-infected patients for proper and timely treatment and patient care.
Surangi H. Thilakarathna, Brendon Parsons, Linda Chui   +2 more
doaj   +2 more sources

Down-Regulation of Renal Klotho Expression by Shiga Toxin 2

Kidney & Blood Pressure Research, 2014
Background/Aims: Shiga toxin 2 may trigger classical hemolytic uremic syndrome (HUS) eventually leading to renal failure. Klotho, a transmembrane protein, protease and hormone mainly expressed in kidney is involved in the regulation of renal phosphate ...
Martina Feger, Sobuj Mia, Tatsiana Pakladok, Jan P. Nicolay, Ioana Alesutan, Stefan W. Schneider, Jakob Voelkl, Florian Lang   +7 more
doaj   +2 more sources

Hemolytic Uremic Syndrome Outbreak in Adults and Shiga Toxin–Producing Escherichia coli Negative for Locus of Enterocyte Effacement, France, 2025 [PDF]

Emerging Infectious Diseases
In January 2025, the Escherichia coli National Reference Center of France detected an outbreak of hemolytic uremic syndrome (HUS) in adults, caused by Shiga toxin–producing E. coli negative for locus of enterocyte effacement (LEE). The outbreak included
Justine de Larminat, Kevin La, Philippe Bidet, André Birgy, Sandrine Liguori, Pierre Phlipaux, Celine Courroux, Florence Crombé, Jorge Blanco, Paul Coppo, Antoine Dossier, Laurence Armand-Lefevre, François Xavier Weill, Carolina Silva Nodari, Gabrielle Jones, Aurelie Cointe, Stéphane Bonacorsi   +16 more
doaj   +2 more sources

Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome

Cell Reports, 2018
Summary: The non-canonical caspase-4 and canonical NLRP3 inflammasomes are both activated by intracellular lipopolysaccharide (LPS), but the crosstalk between these two pathways remains unclear.
Hyunjae Chung, Arthur Lau, Christina F Sandall   +2 more
exaly   +3 more sources

Isothermal Amplification and Lateral Flow Nucleic Acid Test for the Detection of Shiga Toxin-Producing Bacteria for Food Monitoring

Chemosensors, 2022
Foodborne bacteria have persisted as a significant threat to public health and to the food and agriculture industry. Due to the widespread impact of these pathogens, there has been a push for the development of strategies that can rapidly detect ...
Sabrina Petrucci, Emre Dikici, Sylvia Daunert, Sapna K. Deo   +3 more
doaj   +1 more source

Influence of temperature and pH on induction of Shiga toxin Stx1a in Escherichia coli

Frontiers in Microbiology, 2023
Shiga toxin-producing strains represent pathogenic group that is of concern in food production. The present study evaluated forty-eight E. coli isolates (11 with intact stx gene, while remaining isolates presented only stx-fragments) for Shiga toxin ...
Vinicius Silva Castro, Skyler Ngo, Kim Stanford   +2 more
doaj   +1 more source

Shiga Toxin-Producing Escherichia coli: Detection, Differentiation, and Implications for Food Safety

EDIS, 2016
Shiga toxin is a protein found within the genome of a type of virus called a bacteriophage. These bacteriophages can integrate into the genomes of the bacterium E. Coli. Even though most E. coli are benign or even beneficial members of our gut microbial
William J. Zaragoza, Max Teplitski, Clifton K. Fagerquist   +2 more
doaj   +5 more sources

Serine protease EspP from enterohemorrhagic Escherichia coli is sufficient to induce shiga toxin macropinocytosis in intestinal epithelium. [PDF]

PLoS ONE, 2013
Life-threatening intestinal and systemic effects of the Shiga toxins produced by enterohemorrhagic Escherichia coli (EHEC) require toxin uptake and transcytosis across intestinal epithelial cells.
Julie In, Valeriy Lukyanenko, Jennifer Foulke-Abel, Ann L Hubbard, Michael Delannoy, Anne-Marie Hansen, James B Kaper, Nadia Boisen, James P Nataro, Chengru Zhu, Edgar C Boedeker, Jorge A Girón, Olga Kovbasnjuk   +12 more
doaj   +1 more source

Shiga toxin 2-induced intestinal pathology in infant rabbits is A-subunit dependent and responsive to the tyrosine kinase and potential ZAK inhibitor imatinib

Frontiers in Cellular and Infection Microbiology, 2012
Shiga toxin producing Escherichia coli (STEC) are a major cause of food-borne illness worldwide. However, a consensus regarding the role Shiga toxins play in the onset of diarrhea and hemorrhagic colitis is lacking.
Samuel eStone, Cheleste eThorpe, Amrita eAhluwalia, Amrita eAhluwalia, Arlin eRogers, Fumiko eObata, Aimee eVozenilek, Glynis eKolling, Anne eKane, Bruce eMagun, Dakshina eJandhyala   +10 more
doaj   +1 more source