Shiga Toxin: Expression, Distribution, and Its Role in the Environment
Toxins, 2011 In this review, we highlight recent work that has increased our understanding of the production and distribution of Shiga toxin in the environment. Specifically, we review studies that offer an expanded view of environmental reservoirs for Shiga toxin ...
Gerald Koudelka
exaly +4 more sources
Structural Basis of Shiga Toxin Neutralization by Human Antibodies Targeting Canonical Receptor-Binding and Non-Canonical Assembly Sites. [PDF]
Adv Sci (Weinh)Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Ke J +10 more
europepmc +2 more sources
Down-Regulation of Renal Klotho Expression by Shiga Toxin 2
Kidney & Blood Pressure Research, 2014 Background/Aims: Shiga toxin 2 may trigger classical hemolytic uremic syndrome (HUS) eventually leading to renal failure. Klotho, a transmembrane protein, protease and hormone mainly expressed in kidney is involved in the regulation of renal phosphate ...
Martina Feger +7 more
doaj +2 more sources
Microvesicle Involvement in Shiga Toxin-Associated Infection
Toxins, 2017 Shiga toxin is the main virulence factor of enterohemorrhagic Escherichia coli, a non-invasive pathogen that releases virulence factors in the intestine, causing hemorrhagic colitis and, in severe cases, hemolytic uremic syndrome (HUS).
Annie Villysson +2 more
doaj +2 more sources
Cell Reports, 2018 Summary: The non-canonical caspase-4 and canonical NLRP3 inflammasomes are both activated by intracellular lipopolysaccharide (LPS), but the crosstalk between these two pathways remains unclear.
Stephen E Girardin +2 more
exaly +3 more sources
Hemolytic Uremic Syndrome Outbreak in Adults and Shiga Toxin–Producing Escherichia coli Negative for Locus of Enterocyte Effacement, France, 2025 [PDF]
Emerging Infectious DiseasesIn January 2025, the Escherichia coli National Reference Center of France detected an outbreak of hemolytic uremic syndrome (HUS) in adults, caused by Shiga toxin–producing E. coli negative for locus of enterocyte effacement (LEE). The outbreak included
Justine de Larminat +16 more
doaj +2 more sources
Chemosensors, 2022 Foodborne bacteria have persisted as a significant threat to public health and to the food and agriculture industry. Due to the widespread impact of these pathogens, there has been a push for the development of strategies that can rapidly detect ...
Sabrina Petrucci +3 more
doaj +1 more source
Influence of temperature and pH on induction of Shiga toxin Stx1a in Escherichia coli
Frontiers in Microbiology, 2023 Shiga toxin-producing strains represent pathogenic group that is of concern in food production. The present study evaluated forty-eight E. coli isolates (11 with intact stx gene, while remaining isolates presented only stx-fragments) for Shiga toxin ...
Vinicius Silva Castro +2 more
doaj +1 more source
Inhibition of development of Shiga toxin-converting bacteriophages by either treatment with citrate or amino acid starvation [PDF]
, 2012 Objectives: Shiga toxin–producing Escherichia coli (STEC) are pathogenic strains, whose virulence depends on induction of Shiga toxin–converting prophages and their subsequent lytic development.
Bożena Nejman-Faleńczyk +9 more
core +2 more sources
Characterizing RecA-Independent Induction of Shiga toxin2-encoding Phages by EDTA Treatment [PDF]
, 2012 The bacteriophage life cycle has an important role in Shiga toxin (Stx) expression. The induction of Shiga toxin-encoding phages (Stx phages) increases toxin production as a result of replication of the phage genome, and phage lysis of the host cell also
Muniesa Maite +8 more
core +3 more sources