Results 31 to 40 of about 29,285 (250)

The association of shiga-like toxin with detergent-resistant membranes is modulated by glucosylceramide and is an essential requirement in the endoplasmic reticulum for a cytotoxic effect [PDF]

, 2006
Receptor-mediated internalization to the endoplasmic reticulum (ER) and subsequent retro-translocation to the cytosol are essential sequential processes required for the productive intoxication of susceptible mammalian cells by Shiga-like toxin-1 (SLTx).
Falguières, T, Platt, Frances M., Platt, Frances, Roberts, LM, Sillence, DJ, Smith, Daniel C., Jarvis, Rosemary M., Lord, JM, Smith, DC, Lord, J. Michael, Roberts, Lynne M., Jarvis, R. M., Sillence, Daniel J., Johannes, Ludger, Falguires, T., Falguières, Thomas, Lord, Mike, Johannes, L, Roberts, L. M. (Lynne M.), Jarvis, RM, Smith, D. C.   +20 more
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Gas phase characterization of the noncovalent quaternary structure of Cholera toxin and the Cholera toxin B subunit pentamer [PDF]

, 2006
Cholera toxin (CTx) is an AB5 cytotonic protein that has medical relevance in cholera and as a novel mucosal adjuvant. Here, we report an analysis of the noncovalent homopentameric complex of CTx B chain (CTx B5) using electrospray ionization triple ...
Jennings, Keith R., Scrivens, JH, Williams, Jonathan P., Scrivens, James H., Williams, JP, Roberts, LM, Marsden, Brian D., Smith, Daniel C., Marsden, BD, Smith, DC, Roberts, Lynne M., Scrivens, James, Green, BN, Green, Brian N., Roberts, L. M. (Lynne M.), Jennings, KR   +15 more
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Syntaxin 16 and syntaxin 5 are required for efficient retrograde transport of several exogenous and endogenous cargo proteins [PDF]

, 2007
Retrograde transport allows proteins and lipids to leave the endocytic pathway to reach other intracellular compartments, such as trans-Golgi network (TGN)/Golgi membranes, the endoplasmic reticulum and, in some instances, the cytosol. Here, we have used
Falguières, Thomas, Roberts, L., Smith, Daniel C., Lord, J., Fradagrada, Alexandre, Amessou, Mohamed, Amessou, M., Johannes, Ludger, Fradagrada, A., Falguieres, T., Lord, Mike, Roberts, L. M. (Lynne M.), Lamaze, Christophe, Lamaze, C., Johannes, L., Smith, D.   +15 more
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Treatment Strategies for Infections With Shiga Toxin-Producing Escherichia coli

Frontiers in Cellular and Infection Microbiology, 2020
Infections with Shiga toxin-producing Escherichia coli (STEC) cause outbreaks of severe diarrheal disease in children and the elderly around the world. The severe complications associated with toxin production and release range from bloody diarrhea and ...
Sabrina Mühlen, Sabrina Mühlen, Petra Dersch, Petra Dersch   +3 more
doaj   +1 more source

A translational murine model of sub-lethal intoxication with Shiga toxin 2 reveals novel ultrastructural findings in the brain striatum. [PDF]

PLoS ONE, 2013
Infection by Shiga toxin-producing Escherichia coli causes hemorrhagic colitis, hemolytic uremic syndrome (HUS), acute renal failure, and also central nervous system complications in around 30% of the children affected. Besides, neurological deficits are
Carla Tironi-Farinati, Patricia A Geoghegan, Adriana Cangelosi, Alipio Pinto, C Fabian Loidl, Jorge Goldstein   +5 more
doaj   +1 more source

Volume Resuscitation and Progression to Organ Failure in Shiga Toxin-Producing Escherichia coli Infection in Adults

Critical Care Explorations, 2021
OBJECTIVES:. Shiga toxin-producing Escherichia coli infection is associated with dysentery and the hemolytic uremic syndrome, marked by the triad of microangiopathic hemolytic anemia, acute kidney failure, and thrombocytopenia.
Charles G. Volk, MD, Paul M. Cusmano, DO, Richard J. Bower, MD, Terrel Sanders, MD, Ryan C. Maves, MD   +4 more
doaj   +1 more source

Retrograde transport pathways utilised by viruses and protein toxins [PDF]

, 2006
A model has been presented for retrograde transport of certain toxins and viruses from the cell surface to the ER that suggests an obligatory interaction with a glycolipid receptor at the cell surface. Here we review studies on the ER trafficking cholera
J Michael Lord, Lord, Mike, Spooner, Robert A., Smith, Daniel C., Daniel C Smith, Roberts, L. M. (Lynne M.), Andrew J Easton, Easton, A. J. (Andrew J.), Robert A Spooner, Lynne M Roberts   +9 more
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Eeyarestatin 1 interferes with both retrograde and anterograde intracellular trafficking pathways [PDF]

, 2011
Background: The small molecule Eeyarestatin I (ESI) inhibits the endoplasmic reticulum (ER)-cytosol dislocation and subsequent degradation of ERAD (ER associated protein degradation) substrates.
Aletrari, Mina-Olga, Roger Whitehead, Helen Williams, Whitehead, Roger C., Robert A. Spooner, Flitsch, Sabine L., Swanton, Eileithyia, Stephen High, Pietroni, Paola, Eileithyia Swanton, Whitehead, Roger, Vidya Pawar, Sabine L. Flitsch, Sabine L Flitsch, Paola Pietroni, High, Stephen; id_orcid, J Michael Lord, Spooner, Robert A., Lord, J. Michael, McKibbin, Craig, Pawar, Vidya, Williams, Helen, Lord, Mike, Mina-Olga Aletrari, Robert A Spooner, Craig McKibbin, High, Stephen, J. Michael Lord, Aletrari, Mina Olga   +28 more
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Pathogenic Potential to Humans of Bovine Escherichia coli O26, Scotland [PDF]

, 2012
Escherichia coli O26 and O157 have similar overall prevalences in cattle in Scotland, but in humans, Shiga toxin–producing E. coli O26 infections are fewer and clinically less severe than E. coli O157 infections.
Low, JC, Mary F. Hanson, Matthews, L., Alfredo Caprioli, Pollock, K.J., J. Chris Low, Chase-Topping, ME, Caprioli, A, Chase-Topping, M.E., Pearce, M.C., Evans, J., Allison, L.J., Matthews, L, Emily Courcier, Pearce, MC; id_orcid, Michael C. Pearce, David L. Gally, Judith Evans, Courcier, E, Caprioli, A., Locking, M.E., Woolhouse, M.E.J., Allison, LJ, Rosser, T., Handel, I., Louise Matthews, Iain J. McKendrick, Helge Karch, Rosser, T, Gally, DL, Margo E. Chase-Topping, Courcier, E., Tracy Rosser, Gally, D.L., McKendrick, IJ, Evans, J, Karch, H., Hanson, MF, Hanson, Mary, Lesley J. Allison, Low, J.C., Pollock, KGJ, Woolhouse, M.E.; id_orcid, Hanson, M.F., Woolhouse, MEJ, Ian Handel, Pollock, K.G., Mary E. Locking, Karch, H, Kevin G.J. Pollock, Locking, ME, Mark E.J. Woolhouse, Handel, I, McKendrick, I.J.   +53 more
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Shiga Toxin-Producing E. coli in Animals: Detection, Characterization, and Virulence Assessment

, 2021
Cattle and other ruminants are primary reservoirs for Shiga toxin-producing Escherichia coli (STEC) strains which have a highly variable, but unpredictable, pathogenic potential for humans.
Christian Menge, Barth, Stefanie, Christian Berens, Menge, Christian, Stefanie A. Barth, Bauerfeind, Rolf, Rolf Bauerfeind, Berens, Christian   +7 more
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