Shiga Toxins as Antitumor Tools [PDF]
Toxins, 2021 Shiga toxins (Stxs), also known as Shiga-like toxins (SLT) or verotoxins (VT), constitute a family of structurally and functionally related cytotoxic proteins produced by the enteric pathogens Shigella dysenteriae type 1 and Stx-producing Escherichia ...
Aude Robert, Joelle Wiels
exaly +7 more sources
Roles of Shiga Toxins in Immunopathology [PDF]
Toxins, 2019 Shigella species and Shiga toxin-producing Escherichia coli (STEC) are agents of bloody diarrhea that may progress to potentially lethal complications such as diarrhea-associated hemolytic uremic syndrome (D+HUS) and neurological disorders.
Moo-Seung Lee, Vernon L Tesh
exaly +7 more sources
Protection against Shiga Toxins [PDF]
Toxins, 2017 Shiga toxins consist of an A-moiety and five B-moieties able to bind the neutral glycosphingolipid globotriaosylceramide (Gb3) on the cell surface.
Simona Kavaliauskiene +3 more
doaj +6 more sources
Shiga Toxins as Multi-Functional Proteins: Induction of Host Cellular Stress Responses, Role in Pathogenesis and Therapeutic Applications [PDF]
Toxins, 2016 Shiga toxins (Stxs) produced by Shiga toxin-producing bacteria Shigella dysenteriae serotype 1 and select serotypes of Escherichia coli are primary virulence factors in the pathogenesis of hemorrhagic colitis progressing to potentially fatal systemic ...
Moo-Seung Lee +2 more
exaly +4 more sources
Shiga Toxins Induce Apoptosis and ER Stress in Human Retinal Pigment Epithelial Cells [PDF]
Toxins, 2017 Shiga toxins (Stxs) produced by Shiga toxin-producing bacteria Shigella dysenteriae serotype 1 and select serotypes of Escherichia coli are the most potent known virulence factors in the pathogenesis of hemorrhagic colitis progressing to potentially ...
Jun-Young Park +2 more
exaly +4 more sources
Shiga Toxins and the Pathophysiology of Hemolytic Uremic Syndrome in Humans and Animals [PDF]
Toxins, 2012 Food-borne diseases are estimated at 76 million illnesses and 5000 deaths every year in the United States with the greatest burden on young children, the elderly and immunocompromised populations.
Shinichiro Kurosawa +1 more
exaly +4 more sources
AB5 Enterotoxin-Mediated Pathogenesis: Perspectives Gleaned from Shiga Toxins [PDF]
Toxins, 2022 Foodborne diseases affect an estimated 600 million people worldwide annually, with the majority of these illnesses caused by Norovirus, Vibrio, Listeria, Campylobacter, Salmonella, and Escherichia coli. To elicit infections in humans, bacterial pathogens
Erika N. Biernbaum, Indira T. Kudva
doaj +2 more sources
Targeting the Early Endosome-to-Golgi Transport of Shiga Toxins as a Therapeutic Strategy [PDF]
Toxins, 2020 Shiga toxin (STx) produced by Shigella and closely related Shiga toxin 1 and 2 (STx1 and STx2) synthesized by Shiga toxin-producing Escherichia coli (STEC) are bacterial AB5 toxins.
Danyang Li +2 more
doaj +2 more sources
Therapeutic Antibodies Against Shiga Toxins: Trends and Perspectives [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 Shiga toxins (Stx) are AB5-type toxins, composed of five B subunits which bind to Gb3 host cell receptors and an active A subunit, whose action on the ribosome leads to protein synthesis suppression.
Izabella de Macedo Henrique +6 more
doaj +2 more sources
Escherichia coli Shiga Toxins and Gut Microbiota Interactions [PDF]
Toxins, 2021 Escherichia coli (EHEC) and Shigella dysenteriae serotype 1 are enterohemorrhagic bacteria that induce hemorrhagic colitis. This, in turn, may result in potentially lethal complications, such as hemolytic uremic syndrome (HUS), which is characterized by ...
Kyung-Soo Lee +2 more
doaj +2 more sources