Results 11 to 20 of about 130,160 (165)

Shiga Toxins: Intracellular Trafficking to the ER Leading to Activation of Host Cell Stress Responses

open access: yesToxins, 2010
Despite efforts to improve hygenic conditions and regulate food and drinking water safety, the enteric pathogens, Shiga toxin-producing Escherichia coli (STEC) and Shigella dysenteriae serotype 1 remain major public health concerns due to widespread ...
Moo-Seung Lee   +2 more
exaly   +4 more sources

Shiga Toxins as Multi-Functional Proteins: Induction of Host Cellular Stress Responses, Role in Pathogenesis and Therapeutic Applications

open access: yesToxins, 2016
Shiga toxins (Stxs) produced by Shiga toxin-producing bacteria Shigella dysenteriae serotype 1 and select serotypes of Escherichia coli are primary virulence factors in the pathogenesis of hemorrhagic colitis progressing to potentially fatal systemic ...
Dae Gwin Jeong   +2 more
exaly   +4 more sources

The Interactions of Human Neutrophils with Shiga Toxins and Related Plant Toxins: Danger or Safety? [PDF]

open access: yesToxins, 2012
Shiga toxins and ricin are well characterized similar toxins belonging to quite different biological kingdoms. Plant and bacteria have evolved the ability to produce these powerful toxins in parallel, while humans have evolved a defense system that ...
Maurizio Brigotti
exaly   +4 more sources

Detection of Shiga Toxins by Lateral Flow Assay [PDF]

open access: yesToxins, 2015
Shiga toxin-producing Escherichia coli (STEC) produce shiga toxins (Stxs) that can cause human disease and death. The contamination of food products with STEC represents a food safety problem that necessitates rapid and effective detection strategies to ...
Kathryn H. Ching   +5 more
doaj   +3 more sources

Shiga Toxins and the Pathophysiology of Hemolytic Uremic Syndrome in Humans and Animals

open access: yesToxins, 2012
Food-borne diseases are estimated at 76 million illnesses and 5000 deaths every year in the United States with the greatest burden on young children, the elderly and immunocompromised populations.
Shinichiro Kurosawa   +1 more
exaly   +4 more sources

Retrograde transport pathways utilised by viruses and protein toxins [PDF]

open access: yesVirology Journal, 2006
A model has been presented for retrograde transport of certain toxins and viruses from the cell surface to the ER that suggests an obligatory interaction with a glycolipid receptor at the cell surface. Here we review studies on the ER trafficking cholera
Roberts Lynne M   +4 more
doaj   +2 more sources

A High-Throughput, Precipitating Colorimetric Sandwich ELISA Microarray for Shiga Toxins [PDF]

open access: yesToxins, 2014
Shiga toxins 1 and 2 (Stx1 and Stx2) from Shiga toxin-producing E. coli (STEC) bacteria were simultaneously detected with a newly developed, high-throughput antibody microarray platform.
Andrew Gehring   +11 more
doaj   +2 more sources

Rapid and Label-Free Immunosensing of Shiga Toxin Subtypes with Surface Plasmon Resonance Imaging

open access: yesToxins, 2020
Shiga toxin-producing Escherichia coli (STEC) are responsible for gastrointestinal diseases reported in numerous outbreaks around the world as well as in the United States. Current detection methods have limitation to implement for rapid field-deployable
Bin Wang   +3 more
doaj   +2 more sources

Algorithm and Software to Type Stx Operons Accurately from Assembled Genomic Sequence [PDF]

open access: yesMicroorganisms
Shiga toxins in Shiga toxin-producing Escherichia coli (STEC) infections are responsible for bloody diarrhea and serious complications such as hemolytic uremic syndrome.
Arjun Balmiki Prasad   +11 more
doaj   +2 more sources

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