Results 31 to 40 of about 130,160 (165)

Role of Recent Therapeutic Applications and the Infection Strategies of Shiga Toxin-Producing Escherichia coli

Frontiers in Cellular and Infection Microbiology, 2021
Shiga toxin-producing Escherichia coli (STEC) is a global foodborne bacterial pathogen that is often accountable for colon disorder or distress. STEC commonly induces severe diarrhea in hosts but can cause critical illnesses due to the Shiga toxin ...
Su-bin Hwang, Ramachandran Chelliah, Ji Eun Kang, Momna Rubab, Eric Banan-MwineDaliri, Fazle Elahi, Deog-Hwan Oh   +6 more
doaj   +1 more source

Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways [PDF]

, 2007
Rab family guanosine triphosphatases (GTPases) together with their regulators define specific pathways of membrane traffic within eukaryotic cells. In this study, we have investigated which Rab GTPase-activating proteins (GAPs) can interfere with the ...
Evelyn Fuchs, Francis A. Barr, Yoshimura, S. I., Spooner, Robert A., Haas, A. K., Robert A. Spooner, Shin-ichiro Yoshimura, Hass, Alexander K., Fuchs, Evelyn, Lord, Mike, Barr, F. A., Fuchs, E., Lord, J. M., Haas, Alexander K., Spooner, R. A., J. Michael Lord, Alexander K. Haas, Yoshimura, Shin-ichiro, Barr, Francis A.   +18 more
core   +1 more source

Detection of E. coli O157:H7 and Shigella dysenteriae toxins in clinical samples by PCR-ELISA

Brazilian Journal of Infectious Diseases, 2015
Shiga toxin producing bacteria are potential causes of serious human disease such as hemorrhagic colitis, severe inflammations of ileocolonic regions of gastrointestinal tract, thrombocytopenia, septicemia, malignant disorders in urinary ducts, hemolytic
Jafar Amani, Askary Ahmadpour, Abbas Ali Imani Fooladi, Shahram Nazarian   +3 more
doaj   +1 more source

C910 chemical compound inhibits the traffiking of several bacterial AB toxins with cross-protection against influenza virus

iScience, 2022
Summary: The development of anti-infectives against a large range of AB-like toxin-producing bacteria includes the identification of compounds disrupting toxin transport through both the endolysosomal and retrograde pathways.
Yu Wu, Nassim Mahtal, Eléa Paillares, Léa Swistak, Sara Sagadiev, Mridu Acharya, Caroline Demeret, Sylvie Van Der Werf, Florence Guivel-Benhassine, Olivier Schwartz, Serena Petracchini, Amel Mettouchi, Lucie Caramelle, Pierre Couvineau, Robert Thai, Peggy Barbe, Mathilde Keck, Priscille Brodin, Arnaud Machelart, Valentin Sencio, François Trottein, Martin Sachse, Gaëtan Chicanne, Bernard Payrastre, Florian Ville, Victor Kreis, Michel-Robert Popoff, Ludger Johannes, Jean-Christophe Cintrat, Julien Barbier, Daniel Gillet, Emmanuel Lemichez   +31 more
doaj   +1 more source

Active Shiga-like toxin produced by some Aeromonas spp., isolated in Mexico City

Frontiers in Microbiology, 2016
Shiga-like toxins (Stx) represent a group of bacterial toxins involved in human and animal diseases. Stx is produced by enterohemorrhagic Escherichia coli, Shigella dysenteriae type 1, Citrobacter freundii and Aeromonas spp.
Ingrid Palma-Martínez, Andrea Guerrero-Mandujano, Juan Manuel Ruiz-Ruiz, Juan Manuel Ruiz-Ruiz, Cecilia Hernández-Cortez, José Molina-lópez, Virgilio Bocanegra-Garcia, Graciela Castro-Escarpulli   +7 more
doaj   +1 more source

Intimin, tir, and shiga toxin 1 do not influence enteropathogenic responses to shiga toxin-producing Escherichia coli in bovine ligated intestinal loops [PDF]

, 2002
Shiga toxin-producing Escherchia coli (STEC) comprises a group of attaching and effacing (A/E) enteric pathogens of animals and humans. Natural and experimental infection of calves with STEC may result in acute enteritis or subclinical infection ...
Campbell, June, June Campbell, Timothy S. Wallis, Phillips, A D, Oswald, Eric, Campbell, J, Olivier Marchès, Phillips, Alan D., Wallis, Timothy S., Stevens, M P, Veronika Huter, Gad Frankel, Huter, V, Wallis, T S, Mark P. Stevens, Alan D. Phillips, Marchès, Olivier, Huter, Veronika, Marches, O, Oswald, E, Frankel, Gad, Stevens, Mark P., Frankel, G, Eric Oswald   +23 more
core   +1 more source

Tamoxifen blocks retrograde trafficking of Shiga toxin 1 and 2 and protects against lethal toxicosis

Life Science Alliance, 2019
This study reports an unexpected role of late endosome–lysosome fusion in early endosome-to-Golgi trafficking of Shiga toxins and identifies tamoxifen to be a potent inhibitor of Shiga toxicosis. Shiga toxin 1 (STx1) and 2 (STx2), produced by Shiga toxin–
Andrey S Selyunin, Steven Hutchens, Stanton F McHardy, Somshuvra Mukhopadhyay   +3 more
doaj   +1 more source

Baicalein Inhibits Stx1 and 2 of EHE: Effects of Baicalein on the Cytotoxicity, Production, and Secretion of Shiga Toxins of Enterohaemorrhagic Escherichia coli. [PDF]

Toxins (Basel), 2019
Shiga toxin-producing enterohaemorrhagic Escherichia coli (EHEC) O157:H7 is an important foodborne pathogen. Baicalein (5,6,7-trihydroxylflavone), a flavone isolated from the roots of Scutellaria baicalensis, is considered as a potential antibacterial ...
Vinh PT, Shinohara Y, Yamada A, Duc HM, Nakayama M, Ozawa T, Sato J, Masuda Y, Honjoh KI, Miyamoto T.   +9 more
europepmc   +2 more sources

The association of shiga-like toxin with detergent-resistant membranes is modulated by glucosylceramide and is an essential requirement in the endoplasmic reticulum for a cytotoxic effect [PDF]

, 2006
Receptor-mediated internalization to the endoplasmic reticulum (ER) and subsequent retro-translocation to the cytosol are essential sequential processes required for the productive intoxication of susceptible mammalian cells by Shiga-like toxin-1 (SLTx).
Falguières, T, Platt, Frances M., Platt, Frances, Roberts, LM, Sillence, DJ, Smith, Daniel C., Jarvis, Rosemary M., Lord, JM, Smith, DC, Lord, J. Michael, Roberts, Lynne M., Jarvis, R. M., Sillence, Daniel J., Johannes, Ludger, Falguires, T., Falguières, Thomas, Lord, Mike, Johannes, L, Roberts, L. M. (Lynne M.), Jarvis, RM, Smith, D. C.   +20 more
core   +1 more source

Cytosolic entry of Shiga-like toxin A chain from the yeast endoplasmic reticulum requires catalytically active Hrd1p [PDF]

, 2012
Background Escherichia coli Shiga-like toxin 1 normally traffics to the endoplasmic reticulum (ER) in sensitive mammalian cells from where the catalytic A chain (SLTxA1) dislocates to the cytosol to inactivate ribosomes.
Lynne M. Roberts (150050), J Michael Lord, Roberts Lynne M., Spooner, Robert A., Hampton Randolph Y., Lord J. Michael, Robert A. Spooner (150027), Spooner Robert A., Lord, J. Michael, Shuyu Li (18735), Roberts, Lynne M., Randolph Y Hampton, Lynne M Roberts, Shuyu Li, Lord, Mike, J. Michael Lord (150042), Li, Shuyu, Roberts, L. M. (Lynne M.), Robert A Spooner, Randolph Y. Hampton (150034), Li Shuyu, Hampton, Randolph Y.   +21 more
core   +2 more sources