Results 21 to 30 of about 21,994 (199)

Shiga Toxin-Producing Escherichia coli: Detection, Differentiation, and Implications for Food Safety

EDIS, 2016
Shiga toxin is a protein found within the genome of a type of virus called a bacteriophage. These bacteriophages can integrate into the genomes of the bacterium E. Coli. Even though most E. coli are benign or even beneficial members of our gut microbial
William J. Zaragoza, Max Teplitski, Clifton K. Fagerquist   +2 more
doaj   +5 more sources

Serine protease EspP from enterohemorrhagic Escherichia coli is sufficient to induce shiga toxin macropinocytosis in intestinal epithelium. [PDF]

PLoS ONE, 2013
Life-threatening intestinal and systemic effects of the Shiga toxins produced by enterohemorrhagic Escherichia coli (EHEC) require toxin uptake and transcytosis across intestinal epithelial cells.
Julie In, Valeriy Lukyanenko, Jennifer Foulke-Abel, Ann L Hubbard, Michael Delannoy, Anne-Marie Hansen, James B Kaper, Nadia Boisen, James P Nataro, Chengru Zhu, Edgar C Boedeker, Jorge A Girón, Olga Kovbasnjuk   +12 more
doaj   +1 more source

Shiga toxin 2-induced intestinal pathology in infant rabbits is A-subunit dependent and responsive to the tyrosine kinase and potential ZAK inhibitor imatinib

Frontiers in Cellular and Infection Microbiology, 2012
Shiga toxin producing Escherichia coli (STEC) are a major cause of food-borne illness worldwide. However, a consensus regarding the role Shiga toxins play in the onset of diarrhea and hemorrhagic colitis is lacking.
Samuel eStone, Cheleste eThorpe, Amrita eAhluwalia, Amrita eAhluwalia, Arlin eRogers, Fumiko eObata, Aimee eVozenilek, Glynis eKolling, Anne eKane, Bruce eMagun, Dakshina eJandhyala   +10 more
doaj   +1 more source

Down-Regulation of Renal Klotho Expression by Shiga Toxin 2

Kidney & Blood Pressure Research, 2014
Background/Aims: Shiga toxin 2 may trigger classical hemolytic uremic syndrome (HUS) eventually leading to renal failure. Klotho, a transmembrane protein, protease and hormone mainly expressed in kidney is involved in the regulation of renal phosphate ...
Martina Feger, Sobuj Mia, Tatsiana Pakladok, Jan P. Nicolay, Ioana Alesutan, Stefan W. Schneider, Jakob Voelkl, Florian Lang   +7 more
doaj   +1 more source

Mild Illness during Outbreak of Shiga Toxin−Producing Escherichia coli O157 Infections Associated with Agricultural Show, Australia

Emerging Infectious Diseases, 2017
During a large outbreak of Shiga toxin−producing Escherichia coli illness associated with an agricultural show in Australia, we used whole-genome sequencing to detect an IS1203v insertion in the Shiga toxin 2c subunit A gene of Shiga toxin−producing E ...
Bhakti R. Vasant, Russell J. Stafford, Amy V. Jennison, Sonya M. Bennett, Robert J. Bell, Christine J. Doyle, Jeannette R. Young, Susan A. Vlack, Paul Titmus, Debra El Saadi, Kari A.J. Jarvinen, Patricia Coward, Janine Barrett, Megan Staples, Rikki M.A. Graham, Helen V. Smith, Stephen B. Lambert   +16 more
doaj   +1 more source

Roles of Shiga Toxins in Immunopathology [PDF]

Toxins, 2019
Shigella species and Shiga toxin-producing Escherichia coli (STEC) are agents of bloody diarrhea that may progress to potentially lethal complications such as diarrhea-associated hemolytic uremic syndrome (D+HUS) and neurological disorders. The bacteria share the ability to produce virulence factors called Shiga toxins (Stxs).
Moo-Seung Lee, Vernon L. Tesh
openaire   +3 more sources

Laboratory Practices and Incidence of Non-O157 Shiga Toxin–producing Escherichia coli Infections

Emerging Infectious Diseases, 2012
We surveyed laboratories in Washington State, USA, and found that increased use of Shiga toxin assays correlated with increased reported incidence of non-O157 Shiga toxin–producing Escherichia coli (STEC) infections during 2005–2010.
Kathleen A. Stigi, J. Kathryn MacDonald, Anthony A. Tellez-Marfin, Kathryn H. Lofy   +3 more
doaj   +1 more source

Shiga toxin 2 from enterohemorrhagic Escherichia coli induces reactive glial cells and neurovascular disarrangements including edema and lipid peroxidation in the murine brain hippocampus

Journal of Biomedical Science, 2019
Background Shiga toxin 2 from enterohemorrhagic Escherichia coli is the etiologic agent of bloody diarrhea, hemolytic uremic syndrome and derived encephalopathies that may result to death in patients.
Clara Berdasco, Alipio Pinto, Valeria Calabró, David Arenas, Adriana Cangelosi, Patricia Geoghegan, Pablo Evelson, Jorge Goldstein   +7 more
doaj   +1 more source

Microvesicle Involvement in Shiga Toxin-Associated Infection

Toxins, 2017
Shiga toxin is the main virulence factor of enterohemorrhagic Escherichia coli, a non-invasive pathogen that releases virulence factors in the intestine, causing hemorrhagic colitis and, in severe cases, hemolytic uremic syndrome (HUS).
Annie Villysson, Ashmita Tontanahal, Diana Karpman   +2 more
doaj   +1 more source

Protection against Shiga Toxins [PDF]

Toxins, 2017
Shiga toxins consist of an A-moiety and five B-moieties able to bind the neutral glycosphingolipid globotriaosylceramide (Gb3) on the cell surface. To intoxicate cells efficiently, the toxin A-moiety has to be cleaved by furin and transported retrogradely to the Golgi apparatus and to the endoplasmic reticulum.
Simona Kavaliauskiene, Anne Dyve Lingelem, Tore Skotland, Kirsten Sandvig   +3 more
openaire   +4 more sources