Results 61 to 70 of about 958,820 (304)
Frontiers in Cellular and Infection Microbiology, 2020 Shiga toxin is the main virulence factor of non-invasive enterohemorrhagic Escherichia coli strains capable of causing hemolytic uremic syndrome. Our group has previously shown that the toxin can reach the kidney within microvesicles where it is taken up
Karl Johansson +6 more
doaj +1 more source
An Introduction to the Toxins Special Issue on “Novel Pharmacological Inhibitors for Bacterial Protein Toxins” [PDF]
Toxins, 2017 Bacterial AB-type protein toxins that consist of an enzymatically active subunit (A) and a binding/transport subunit (B), are among the most toxic substances and represent the causative agents for a variety of severe human and animal diseases, such as in the context of infections, post-traumatic complications or food poisoning.[...]
openaire +4 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Adult survivors of childhood acute lymphoblastic leukemia (ALL) are at risk of reduced exercise capacity, decreased physical activity levels, persistent fatigue, and neurocognitive deficits. The aim was to investigate exercise capacity and physical activity levels of adult survivors of childhood ALL and their associations with ...
Laura Jess +5 more
wiley +1 more source
Botulinum toxin-A for the treatment of overactive bladder: UK contributions [PDF]
, 2013 Background: Botulinum toxin-A (BoNT/A) is now established second-line management for refractory overactivebladder (OAB) and recognised in many incontinence guidelines and pathways.
Fowler, CJ +13 more
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background and Aims Infant bone and soft tissue neoplasms present distinct clinical challenges and lack large‐scale data to inform treatment decisions. This study aims to characterize bone and soft tissue neoplasms in infants in Canada and to compare their outcomes with those of older pediatric patients.
Samuel Sassine +21 more
wiley +1 more source
The Biochemistry of VapBC Toxin-Antitoxins [PDF]
, 2011 The VapBC toxin-antitoxin (TA) systems were first identified in 2005 and little is known about their contemporary biological function, despite the fact that VapBC TAs are the largest TA family and are widespread in bacteria and archaea (Arcus, Rainey ...
McKenzie, Joanna Leigh
core
The role of TcdB and TccC subunits in secretion of the photorhabdus Tcd toxin complex [PDF]
, 2013 The Toxin Complex (TC) is a large multi-subunit toxin encoded by a range of bacterial pathogens. The best-characterized examples are from the insect pathogens Photorhabdus, Xenorhabdus and Yersinia.
Guowei Yang +7 more
core +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
How ricin and shiga toxin reach the cytosol of target cells : retrotranslocation from the endoplasmic reticulum [PDF]
, 2012 A number of protein toxins bind at the surface of mammalian cells and after endocytosis traffic to the endoplasmic reticulum, where the toxic A chains are liberated from the holotoxin.
Lord, Mike, Spooner, Robert A.
core