Results 81 to 90 of about 958,820 (304)

Bacterial toxin-antitoxin systems [PDF]

Mobile Genetic Elements, 2011
Toxin-antitoxin (TA) systems are composed of two elements: a toxic protein and an antitoxin which is either an RNA (type I and III) or a protein (type II). Type II systems are abundant in bacterial genomes in which they move via horizontal gene transfer.
Guglielmini, Julien, van Melderen, Laurence   +1 more
openaire   +4 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Noradrenaline release from permeabilized synaptosomes is inhibited by the light chain of tetanus toxin [PDF]

, 1992
Noradrenaline release from rat brain cortical synaptosomes permeabilized with streptolysin O can be triggered by μM concentrations of free Ca2+. This process was inhibited within minutes by tetanus toxin and its isolated light chain, but not by its heavy
Stecher, Brigitte, Weller, U., De Graan, P., Gratzl, Manfred, Graan, P.N.E. de, Gratz, M., Hens, Jacques J.H., Stecher, B., Gispen, W. H., De Graan, Pierre N.E., Hens, J.J.H., Hens, J., Jacques J.H. Hens, Ulrich Weller, Willem-Hendrik Gispen, Pierre N.E. De Graan, Manfred Gratzl, Gispen, Willem-Hendrik, Gispen, W.H., Weller, Ulrich, Brigitte Stecher   +20 more
core   +2 more sources

Alpha-1 antitrypsin inhibits Clostridium botulinum C2 toxin, Corynebacterium diphtheriae diphtheria toxin and B. anthracis fusion toxin

Scientific Reports
The bacterium Clostridium botulinum, well-known for producing botulinum neurotoxins, which cause the severe paralytic illness known as botulism, produces C2 toxin, a binary AB-toxin with ADP-ribosyltranferase activity.
Stefanie Lietz, Lena-Marie Sokolowski, Holger Barth, Katharina Ernst   +3 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Intimin, tir, and shiga toxin 1 do not influence enteropathogenic responses to shiga toxin-producing Escherichia coli in bovine ligated intestinal loops [PDF]

, 2002
Shiga toxin-producing Escherchia coli (STEC) comprises a group of attaching and effacing (A/E) enteric pathogens of animals and humans. Natural and experimental infection of calves with STEC may result in acute enteritis or subclinical infection ...
Campbell, June, June Campbell, Timothy S. Wallis, Phillips, A D, Oswald, Eric, Campbell, J, Olivier Marchès, Phillips, Alan D., Wallis, Timothy S., Stevens, M P, Veronika Huter, Gad Frankel, Huter, V, Wallis, T S, Mark P. Stevens, Alan D. Phillips, Marchès, Olivier, Huter, Veronika, Marches, O, Oswald, E, Frankel, Gad, Stevens, Mark P., Frankel, G, Eric Oswald   +23 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A novel Hsp70 inhibitor prevents cell intoxication with the actin ADP-ribosylating Clostridium perfringens iota toxin [PDF]

, 2016
International audienceHsp70 family proteins are folding helper proteins involved in a wide variety of cellular pathways. Members of this family interact with key factors in signal transduction, transcription, cell-cycle control, and stress response. Here,
Barth, Holger, Schiene-Fischer, Cordelia, Popoff, Michel, Schmid, Johannes, Ihmels, Heiko, Mathea, Sebastian, Ernst, Katharina, Liebscher, Markus, Granzhan, Anton   +8 more
core   +1 more source

T-2 toxin-induced testicular impairment by triggering oxidative stress and ferroptosis

Ecotoxicology and Environmental Safety
T-2 toxin is a trichothecene mycotoxin of significant danger to humans and animals. Its impact on reproductive toxicity is attributed to oxidative stress, which ultimately leads to cell death.
Jun He, Hong Jin, Jiabin Guo, Kexin Li, Li Jia, Yujie Li, Li Zhang   +6 more
doaj   +1 more source