Results 101 to 110 of about 209,245 (296)

A common origin for the bacterial toxin-antitoxin systems parD and ccd, suggested by analyses of toxin/target and toxin/antitoxin interactions.

PLoS ONE, 2012
Bacterial toxin-antitoxin (TA) systems encode two proteins, a potent inhibitor of cell proliferation (toxin) and its specific antidote (antitoxin). Structural data has revealed striking similarities between the two model TA toxins CcdB, a DNA gyrase ...
Andrew B Smith, Juan López-Villarejo, Elizabeth Diago-Navarro, Lesley A Mitchenall, Arjan Barendregt, Albert J Heck, Marc Lemonnier, Anthony Maxwell, Ramón Díaz-Orejas   +8 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

BPTES inhibits anthrax lethal toxin-induced inflammatory response

, 2020
Bacillus anthracis is a lethal agent of anthrax disease and the toxins are required in anthrax pathogenesis. The anthrax lethal toxin can trigger NLRP1b inflammasome activation and pyroptosis.
Shen, Xizi, Zhong, Jiaying, Zhao, Yilin, Wang, Jinling, Liu, Xiaomei, Wang, Junsheng, Lin, Jinzhou, Qi, Zhongquan, Yang, Daowei   +8 more
core   +1 more source

Ricin trafficking in plant and mammalian cells [PDF]

, 2011
Ricin is a heterodimeric plant protein that is potently toxic to mammalian and many other eukaryotic cells. It is synthesized and stored in the endosperm cells of maturing Ricinus communis seeds (castor beans).
Lord, Mike, Spooner, Robert A., Robert A. Spooner, J. Michael Lord   +3 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Functional dissection of the retrograde Shiga toxin trafficking inhibitor Retro-2

, 2020
International audienceThe retrograde transport inhibitor Retro-2 has a protective effect on cells and in mice against Shiga-like toxins and ricin. Retro-2 causes toxin accumulation in early endosomes and relocalization of the Golgi SNARE protein syntaxin-
Raphael Sierocki, Julien Barbier, Sierocki, Raphael, Florent Dingli, Bachert, Collin, Renard, Henri-François, Dingli, Florent, Alison Forrester, Collin Bachert, Munier, Mathilde, Pichard, Sylvain, Sylvain Pichard, Stefan J. Rathjen, Henri-François Renard, Daniel Gillet, Gillet, Daniel, Damarys Loew, Loew, Damarys, Augusto Valades-Cruz, César, Ludger Johannes, Cintrat, Jean-Christophe, Adam D. Linstedt, Couhert, Audrey, Jean-Christophe Cintrat, Linstedt, Adam, Martinez, Jennifer, Audrey Couhert, Rathjen, Stefan, Livia Tepshi, César Augusto Valades-Cruz, Johannes, Ludger, Forrester, Alison, Christophe Lamaze, Barbier, Julien, Lamaze, Christophe, Daniela Garcia-Castillo, Maria, Mathilde Munier, Jennifer Martinez, Maria Daniela Garcia-Castillo, Tepshi, Livia   +39 more
core   +1 more source

Pharmacoinformatic Investigation of Silymarin as a Potential Inhibitor against Nemopilema nomurai Jellyfish Metalloproteinase Toxin-like Protein

, 2023
Jellyfish stings pose a major threat to swimmers and fishermen worldwide. These creatures have explosive cells containing one large secretory organelle called a nematocyst in their tentacles, which contains venom used to immobilize prey.
Ravi Deva Asirvatham, Ramachandran Loganathan Mohan Prakash, Changkeun Kang, Du Hyeon Hwang, Euikyung Kim   +4 more
core   +1 more source

Administration of novobiocin and apomorphine mitigates cholera toxin mediated cellular toxicity: Lessons from cholera toxin yeast model system.

PLoS ONE
Cholera is a dreadful disease. The scourge of this deadly disease is still evident in the developing world. Though several therapeutic strategies are in practice to combat and contain the disease, there is still a need for new drugs to control the ...
Sonali Eknath Bhalerao, Himanshu Sen, Saumya Raychaudhuri   +2 more
doaj   +1 more source

Effects of Nitric Oxide and Reactive Oxygen Species on HIF-1α Stabilization Following Clostridium Difficile Toxin Exposure of the Caco-2 Epithelial Cell Line

Cellular Physiology and Biochemistry, 2013
Background/Aims: Stabilization of the hypoxia-inducible factor (HIF-1α) is proposed to provide a protective host-response to C. difficile intoxication.
Joshua Y. Lee, Simon A. Hirota, Louise E. Glover, Glen D. Armstrong, Paul L. Beck, Justin A. MacDonald   +5 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source