Results 91 to 100 of about 209,245 (296)

Treatment of Clostridium difficile Infection with a Small-Molecule Inhibitor of Toxin UDP-Glucose Hydrolysis Activity

, 2018
Clostridium difficile infection (CDI) is the leading cause of hospital-acquired infectious diarrhea, with significant morbidity, mortality, and associated health care costs.
Igor Pechik, Maria L. Webb, Teresa E. Miller, Linh Ma, Philip D. Stein, David W. Hilbert, Laurie J. Sturzenbecker, Ilana L. Stroke, Jeffrey J. Letourneau, Joan Sabalski, Diana R. Savoly, Yan Xu   +11 more
core   +1 more source

Comparative evaluation of chromium methionine chelate and Nano chromium in alleviating Zearalenone-Induced oxidative stress

Current Research in Biotechnology
Zearalenone, a mycotoxin from Fusarium fungi found in contaminated feed, poses toxicity risks to livestock. The administration of antioxidant compounds has emerged as a potential approach for mitigating zearalenone-induced toxicity.
Mohammad Alizadeh, Arash Abolhassani, Amirhosein Zanjani Tabasi, Golnoush Shirkhani, Asal Ghahreman, Negin Shafaei, Ehsan Oskoueian, Ehsan Karimi   +7 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The Biochemistry of VapBC Toxin-Antitoxins

, 2011
The VapBC toxin-antitoxin (TA) systems were first identified in 2005 and little is known about their contemporary biological function, despite the fact that VapBC TAs are the largest TA family and are widespread in bacteria and archaea (Arcus, Rainey ...
McKenzie, Joanna Leigh
core  

Toxicological effects of hypoxanthine on Heterosigmaakashiwo: Mechanism of growth inhibition and change in hemolytic toxin content

, 2021
Heterosigmaakashiwo is an algal species that causes harmful algal blooms (HABs) with strong hemolytic toxicity on coastal aquatic organisms. This study investigated the mechanism of growth inhibition and changes in hemolytic toxin contents in algal ...
Qiming Jimmy Yu, Zhao, Ling, Binbin Chen, Ling Zhao, Chen, Binbin, Yu, Qiming Jimmy   +5 more
core   +1 more source

Clostridium perfringens Alpha-Toxin Induces Gm1a Clustering and Trka Phosphorylation in the Host Cell Membrane.

PLoS ONE, 2015
Clostridium perfringens alpha-toxin elicits various immune responses such as the release of cytokines, chemokines, and superoxide via the GM1a/TrkA complex.
Teruhisa Takagishi, Masataka Oda, Michiko Kabura, Mie Kurosawa, Kaori Tominaga, Shiori Urano, Yoshibumi Ueda, Keiko Kobayashi, Toshihide Kobayashi, Jun Sakurai, Yutaka Terao, Masahiro Nagahama   +11 more
doaj   +1 more source

Snake venom toxin from vipera lebetina turanica induces apoptosis of colon cancer cells via upregulation of ROS- and JNK-mediated death receptor expression

BMC Cancer, 2012
Background Abundant research suggested that the cancer cells avoid destruction by the immune system through down-regulation or mutation of death receptors.
Park Mi, Jo MiRan, Won Dohee, Song Ho, Han Sang, Song Min, Hong Jin   +6 more
doaj   +1 more source

Inhibitors of synaptic vesicle exocytosis reduce surface expression of postsynaptic glutamate receptors

Animal Cells and Systems, 2020
Bafilomycin A1, a vacuolar H+-ATPase inhibitor, and botulinum toxin B and tetanus toxin, both vesicle fusion inhibitors, are widely known exocytosis blockers that have been used to inhibit the presynaptic release of neurotransmitters.
Dong Ho Woo, Young-Na Hur, Minwoo Wendy Jang, C. Justin Lee, Mikyoung Park   +4 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Novel genes for insect resistance in transgenic plants [PDF]

, 1995
From a cDNA library of potato tuber, cDNAs for the potato carboxypeptidase inhibitors were isolated and characterised by DNA sequencing. One full length clone of each type was used to make plant expression constructs, and these constructs used to ...
Gatehouse, Laurence Neil
core