Results 71 to 80 of about 958,820 (304)

Enhancement of toxin- and virus-neutralizing capacity of single-domain antibody fragments by N-glycosylation [PDF]

, 2009
Single-domain antibody fragments (VHHs) have several beneficial properties as compared to conventional antibody fragments. However, their small size complicates their toxin- and virus-neutralizing capacity.
Fijten, H.P.D., Smits, C.B., H. P. D. Fijten, C. B. van Solt, Harmsen, M.M., M. M. Harmsen   +5 more
core   +1 more source

Neurotransmitter evaluation in the hippocampus of rats after intracerebral injection of TsTX scorpion toxin

Journal of Venomous Animals and Toxins including Tropical Diseases, 2009
TsTX is an α-type sodium channel toxin that stimulates the discharge of neurotransmitters from neurons. In the present study we investigated which neurotransmitters are released in the hippocampus after TsTX injection and if they are responsible for
ALA Nencioni, SA Barreto, I Lebrun, JC Florio, GA Lourenço, VAC Dorce   +5 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Chaperone-mediated native folding of a β-scorpion toxin in the periplasm of E.coli [PDF]

, 2014
Background: Animal neurotoxin peptides are valuable probes for investigating ion channel structure/function relationships and represent lead compounds for novel therapeutics and insecticides.
Cole, Ambrose R., Lampert, A., Wallace, Bonnie A., O'Reilly, A.O., O’Reilly, A.O., Wallace, B.A., Cole, A.R., Lopes, J.L.S.   +7 more
core   +1 more source

Proteo-Transcriptomic Analysis Identifies Potential Novel Toxins Secreted by the Predatory, Prey-Piercing Ribbon Worm Amphiporus lactifloreus

Marine Drugs, 2020
Nemerteans (ribbon worms) employ toxins to subdue their prey, but research thus far has focused on the small-molecule components of mucus secretions and few protein toxins have been characterized.
Björn Marcus von Reumont, Tim Lüddecke, Thomas Timm, Günter Lochnit, Andreas Vilcinskas, Jörn von Döhren, Maria A. Nilsson   +6 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Adenylylation of Gyrase and Topo IV by FicT Toxins Disrupts Bacterial DNA Topology [PDF]

, 2015
Toxin-antitoxin (TA) modules are ubiquitous molecular switches controlling bacterial growth via the release of toxins that inhibit cell proliferation.
Gerdes, K., Glatter, Timo, Dehio, Christoph, Alexander Harms, Goepfert, A., Scheu, P., Kenn Gerdes, Glatter, T. ; https://orcid.org/, Schirmer, T., Harms, Alexander, Christoph Dehio, Harms, A., Timo Glatter, Stanger, Frédéric Valentin, Gerdes, Kenn, Dehio, C., Schirmer, Tilman, Harms, Alexander; id_orcid, de Jong, I., de Jong, Imke Greet, Stanger, F., Tilman Schirmer, Patrick Daniel Scheu, Arnaud Goepfert, Scheu, Patrick Daniel, Frédéric Valentin Stanger, Imke Greet de Jong, Goepfert, Arnaud   +27 more
core   +1 more source

Characterizing RecA-Independent Induction of Shiga toxin2-encoding Phages by EDTA Treatment [PDF]

, 2012
The bacteriophage life cycle has an important role in Shiga toxin (Stx) expression. The induction of Shiga toxin-encoding phages (Stx phages) increases toxin production as a result of replication of the phage genome, and phage lysis of the host cell also
Muniesa Maite, Lejla Imamovic (180270), Lejla Imamovic, Maite Muniesa (66350), Maite Muniesa, Imamovic Lejla, Muniesa Pérez, Ma. Teresa, Muniesa Pérez, Ma Teresa, Imamovic, Lejla   +8 more
core   +3 more sources

The relationship between the metabolism of sphingomyelin species and the hemolysis of sheep erythrocytes induced by Clostridium perfringens α-toxins⃞

Journal of Lipid Research, 2008
Clostridium perfringens α-toxin induces the hemolysis of sheep erythrocytes by activating the metabolism of sphingomyelin (SM) via a GTP binding protein in membranes.
Masataka Oda, Takayuki Matsuno, Ryouta Shiihara, Sadayuki Ochi, Rieko Yamauchi, Yuki Saito, Hiroshi Imagawa, Masahiro Nagahama, Mugio Nishizawa, Jun Sakurai   +9 more
doaj   +1 more source

Structure-guided design of a potent Clostridioides difficile toxin A inhibitor

Frontiers in Microbiology, 2023
Crystal structures of camelid heavy-chain antibody variable domains (VHHs) bound to fragments of the combined repetitive oligopeptides domain of Clostridioides difficile toxin A (TcdA) reveal that the C-terminus of VHH A20 was located 30 Å away from the ...
Greg Hussack, Martin A. Rossotti, Henk van Faassen, Tomohiko Murase, Luiz Eugenio, Joseph D. Schrag, Kenneth K.-S. Ng, Kenneth K.-S. Ng, Jamshid Tanha, Jamshid Tanha   +9 more
doaj   +1 more source