Results 11 to 20 of about 66,837 (297)
Inhibition of Cholera Toxin and Other AB Toxins by Polyphenolic Compounds.
PLoS ONE, 2016 Cholera toxin (CT) is an AB-type protein toxin that contains a catalytic A1 subunit, an A2 linker, and a cell-binding B homopentamer. The CT holotoxin is released into the extracellular environment, but CTA1 attacks a target within the cytosol of a host ...
Patrick Cherubin +13 more
doaj +7 more sources
mBio, 2015 The macrophage response to planktonic Staphylococcus aureus involves the induction of proinflammatory microbicidal activity. However, S. aureus biofilms can interfere with these responses in part by polarizing macrophages toward an anti-inflammatory ...
Tyler D. Scherr +8 more
doaj +6 more sources
Toxin Instability and Its Role in Toxin Translocation from the Endoplasmic Reticulum to the Cytosol
Biomolecules, 2013 AB toxins enter a host cell by receptor-mediated endocytosis. The catalytic A chain then crosses the endosome or endoplasmic reticulum (ER) membrane to reach its cytosolic target. Dissociation of the A chain from the cell-binding B chain occurs before or
Ken Teter
doaj +2 more sources
AIP56, an AB toxin secreted by <i>Photobacterium damselae</i> subsp. <i>piscicida</i>, has tropism for myeloid cells. [PDF]
Front ImmunolAbstract The AB-type toxin AIP56 is a key virulence factor of Photobacterium damselae subsp. piscicida ( Phdp ), inducing apoptosis in fish immune cells.
Freitas IL +5 more
europepmc +7 more sources
Pet, a Non-AB Toxin, Is Transported and Translocated into Epithelial Cells by a Retrograde Trafficking Pathway [PDF]
Infection and Immunity, 2007 ABSTRACT The plasmid-encoded toxin (Pet) of enteroaggregative Escherichia coli is a 104-kDa autotransporter protein that exhibits proteolytic activity against the actin-binding protein α-fodrin. Intracellular cleavage of epithelial fodrin by Pet disrupts the actin cytoskeleton, causing both cytotoxic and ...
Navarro-GarcÃa, Fernando +4 more
openaire +5 more sources
AB Toxins: A Paradigm Switch from Deadly to Desirable [PDF]
Toxins, 2010 To ensure their survival, a number of bacterial and plant species have evolved a common strategy to capture energy from other biological systems. Being imperfect pathogens, organisms synthesizing multi-subunit AB toxins are responsible for the mortality ...
Oludare Odumosu +3 more
doaj +3 more sources
Sensors, 2010 This study describes the direct detection of the biological toxin (Ricin) in acidic environment without pH adjustment by hydrophobically modified electrochemical impedance immunosensor (EII). The nano-porous aluminum substrate for EII was hydrophobically
Changhoon Chai +2 more
doaj +2 more sources
Scientific ReportsThe bacterium Clostridium botulinum, well-known for producing botulinum neurotoxins, which cause the severe paralytic illness known as botulism, produces C2 toxin, a binary AB-toxin with ADP-ribosyltranferase activity.
Stefanie Lietz +3 more
doaj +3 more sources
Journal of Lasers in Medical Sciences, 2018 Type II toxin-antitoxin (TA) systems are the particular type of TA modules which take part in different kinds of cellular actions, such as biofilm formation, persistence, stress endurance, defense of the bacterial cell against multiple phage attacks, plasmid maintenance, and programmed cell death in favor of bacterial population.
Hosseini, Nava +5 more
openaire +4 more sources
Diphtheria and the AB Toxin Group
, 2023 AB toxins have historically been associated with significant morbidity, mortality through infections such as botulinum, anthrax, cholera, and diphtheria. These AB toxin-mediated diseases remain prevalent in low and middle income countries, with intermittent outbreaks of Shiga toxin-producing Escherichia coli (STEC) or whooping cough by Bordetella ...
Billy Pembroke +4 more
openaire +1 more source