Results 11 to 20 of about 232 (115)
Inhibition of Cholera Toxin and Other AB Toxins by Polyphenolic Compounds.
PLoS ONE, 2016 Cholera toxin (CT) is an AB-type protein toxin that contains a catalytic A1 subunit, an A2 linker, and a cell-binding B homopentamer. The CT holotoxin is released into the extracellular environment, but CTA1 attacks a target within the cytosol of a host ...
Patrick Cherubin +13 more
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AB Toxins: A Paradigm Switch from Deadly to Desirable [PDF]
Toxins, 2010 To ensure their survival, a number of bacterial and plant species have evolved a common strategy to capture energy from other biological systems. Being imperfect pathogens, organisms synthesizing multi-subunit AB toxins are responsible for the mortality ...
Oludare Odumosu +3 more
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mBio, 2015 The macrophage response to planktonic Staphylococcus aureus involves the induction of proinflammatory microbicidal activity. However, S. aureus biofilms can interfere with these responses in part by polarizing macrophages toward an anti-inflammatory ...
Tyler D. Scherr +8 more
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Diphtheria and the AB Toxin Group
, 2023 AB toxins have historically been associated with significant morbidity, mortality through infections such as botulinum, anthrax, cholera, and diphtheria. These AB toxin-mediated diseases remain prevalent in low and middle income countries, with intermittent outbreaks of Shiga toxin-producing Escherichia coli (STEC) or whooping cough by Bordetella ...
Billy Pembroke +4 more
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AB Toxins as High-Affinity Ligands for Cell Targeting in Cancer Therapy
International Journal of Molecular Sciences, 2023 Conventional targeted therapies for the treatment of cancer have limitations, including the development of acquired resistance. However, novel alternatives have emerged in the form of targeted therapies based on AB toxins. These biotoxins are a diverse group of highly poisonous molecules that show a nanomolar affinity for their target cell receptors ...
Márquez López, Ana +1 more
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Direct IgG epitope mapping on bacterial AB toxins by cryo-EM
STAR Protocols, 2021 This cryo-EM protocol was used to determine the B cell epitope map on the CdtB subunit of typhoid toxin, an A2B5 toxin secreted by Salmonella Typhi during infection. Immunoglobulin G (IgG) was directly mixed with typhoid toxin in this protocol, different from our previous cryo-EM protocol that uses the Fab fragments in place of IgG.
Tri Nguyen, Jeongmin Song
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Sensitivity of Kupffer cells and liver sinusoidal endothelial cells to ricin toxin and ricin toxin–Ab complexes [PDF]
Journal of Leukocyte Biology, 2019 Abstract Ricin toxin is a plant-derived, ribosome-inactivating protein that is rapidly cleared from circulation by Kupffer cells (KCs) and liver sinusoidal endothelial cells (LSECs)—with fatal consequences. Rather than being inactivated, ricin evades normal degradative pathways and kills both KCs and LSECs with remarkable efficiency ...
Bridget Mooney +4 more
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PLoS ONE, 2012 Antitoxins are needed that can be produced economically with improved safety and shelf life compared to conventional antisera-based therapeutics. Here we report a practical strategy for development of simple antitoxin therapeutics with substantial ...
Jean Mukherjee +11 more
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Cholera toxin B subunits assemble into pentamers--proposition of a fly-casting mechanism. [PDF]
PLoS ONE, 2010 The cholera toxin B pentamer (CtxB(5)), which belongs to the AB(5) toxin family, is used as a model study for protein assembly. The effect of the pH on the reassembly of the toxin was investigated using immunochemical, electrophoretic and spectroscopic ...
Jihad Zrimi +4 more
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Cytolethal Distending Toxin: A Unique Variation on the AB Toxin Paradigm [PDF]
New Journal of Science, 2014 Some of the most potent toxins produced by plants and bacteria are members of a large family known as the AB toxins. AB toxins are generally characterized by a heterogenous complex consisting of two protein chains arranged in various monomeric or polymeric configurations. The newest class within this superfamily is the cytolethal distending toxin (Cdt).
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