Results 41 to 50 of about 66,837 (297)
Antibody-Mediated Inhibition of Ricin Toxin Retrograde Transport
mBio, 2014 Ricin is a member of the ubiquitous family of plant and bacterial AB toxins that gain entry into the cytosol of host cells through receptor-mediated endocytosis and retrograde traffic through the trans-Golgi network (TGN) and endoplasmic reticulum (ER ...
Anastasiya Yermakova +4 more
doaj +1 more source
Medical Countermeasures against Ricin Intoxication
Toxins, 2023 Ricin toxin is a disulfide-linked glycoprotein (AB toxin) comprising one enzymatic A chain (RTA) and one cell-binding B chain (RTB) contained in the castor bean, a Ricinus species.
Christine Rasetti-Escargueil +1 more
doaj +1 more source
AB 5 Preassembly Is Not Required for Shiga Toxin Activity [PDF]
Journal of Bacteriology, 2016 ABSTRACT Shiga toxin (Stx)-producing Escherichia coli (STEC) is a major cause of foodborne illness, including the life-threatening complication hemolytic-uremic syndrome. The German outbreak in 2011 resulted in nearly 4,000 cases of infection, with 54 deaths.
Christine A, Pellino +3 more
openaire +2 more sources
Clostridium and Bacillus Binary Enterotoxins: Bad for the Bowels, and Eukaryotic Being
Toxins, 2014 Some pathogenic spore-forming bacilli employ a binary protein mechanism for intoxicating the intestinal tracts of insects, animals, and humans. These Gram-positive bacteria and their toxins include Clostridium botulinum (C2 toxin), Clostridium difficile (
Bradley G. Stiles +5 more
doaj +1 more source
Role of Homologous Fc Fragment in the Potency and Efficacy of Anti‐Botulinum Antibody Preparations
Toxins, 2017 The only approved treatment for botulism relies on passive immunity which is mostly based on antibody preparations collected from hyper‐immune horses. The IgG Fc fragment is commonly removed from these heterologous preparations to reduce the incidence of
Amram Torgeman +9 more
doaj +1 more source
Human Peptides α-Defensin-1 and -5 Inhibit Pertussis Toxin
Toxins, 2021 Bordetella pertussis causes the severe childhood disease whooping cough, by releasing several toxins, including pertussis toxin (PT) as a major virulence factor.
Carolin Kling +3 more
doaj +1 more source
Characterizing RecA-Independent Induction of Shiga toxin2-encoding Phages by EDTA Treatment
, 2013 The bacteriophage life cycle has an important role in Shiga toxin (Stx) expression. The induction of Shiga toxin-encoding phages (Stx phages) increases toxin production as a result of replication of the phage genome, and phage lysis of the host cell also
Muniesa Pérez, Ma. Teresa +1 more
core +1 more source
Draft Genome Sequence of an Escherichia coli O157:H43 Strain Isolated from Cattle
, 2013 Here we report the draft genome sequence of an Escherichia coli O157:H43 strain, designated T22, with an atypical virulence gene profile and isolated from healthy cattle.
Maróti, Gergely +4 more
core +1 more source
Purification and some properties of Clostridium botulinum type AB toxin [PDF]
FEMS Microbiology Letters, 1986 Abstract The progenitor toxin of Clostridium botulinum type AB was purified; both large-sized (L) and medium-sized (M) toxins were found. The toxicity of M toxin increased by about 10-fold upon trypsinization; the increase was due mostly to type B toxin and a little to type A toxin.
openaire +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source