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Acta Pharmaceutica Sinica B, 2020 Ricin is a highly toxic type 2 ribosome-inactivating protein (RIP) which is extracted from the seeds of castor beans. Ricin is considered a potential bioterror agent and no effective antidote for ricin exists so far.
Wu Zhong, Xingzhou Li, Yuxia Wang
exaly +3 more sources
Antibodies, 2013 Ricin is a type II ribosome inactivating protein (RIP) isolated from castor beans. Its high toxicity classifies it as a possible biological weapon. On the other hand, ricin linked to specific monoclonal antibodies or used in other conjugates has powerful
Monika Słomińska, Kirsten Sandvig
exaly +3 more sources
Ricin Antibodies’ Neutralizing Capacity Against Different Ricin Isoforms and Cultivars
Toxins, 2021 Ricin, a highly toxic protein from Ricinus communis, is considered a potential biowarfare agent. Despite the many data available, no specific treatment has yet been approved.
François Fenaille +2 more
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Rational development of an mRNA antibody cocktail with extended therapeutic window against ricin intoxication [PDF]
Applied Microbiology and BiotechnologyRicin, a highly toxic protein derived from Ricinus communis, is recognized as a biological threat due to its high toxicity and the absence of approved specific antidotes.
Mei Wu +14 more
doaj +2 more sources
Differential Thermal Inactivation Enables Simultaneous Quantitation of Ricin and Abrin [PDF]
ToxinsRicin and abrin are highly lethal Type II ribosome-inactivating proteins. They depurinate the same site of the 28S rRNA to inhibit protein synthesis. Consequently, standard molecular-level activity assays used to detect the toxic activity of ricin or ...
Woo-Hyeon Jeong
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Ricin Toxicity to Intestinal Cells Leads to Multiple Cell Death Pathways Mediated by Oxidative Stress [PDF]
ToxinsRicin, a type 2 ribosome-inactivating protein, is a lethal toxin found in castor bean seeds. Although the systemic toxicity of ricin has been extensively studied, its localized effect on the gastrointestinal tract remains a critical concern, particularly
Francesco Biscotti +5 more
doaj +2 more sources
Autophagic Degradation Is Involved in Cell Protection against Ricin Toxin
Toxins, 2023 Autophagy is a complex and highly regulated degradative process, which acts as a survival pathway in response to cellular stress, starvation and pathogen infection.
Yu Wu +8 more
doaj +1 more source
Purified Immunoglobulin F(ab′) 2 Protects Mice and Rhesus Monkeys against Lethal Ricin Intoxication
Zoonoses, 2023 Ricin is a highly toxic ribosome-inactivating lectin derived from castor beans. To date, no antidote is available to treat ricin-poisoned patients, and the development of a safe and effective antidote is urgently needed.
Jingjing Tian +16 more
doaj +1 more source
Toxins, 2022 Ricin is a toxin which enters cells and depurinates an adenine base in the sarcin-ricin loop in the large ribosomal subunit, leading to the inhibition of protein translation and cell death.
Yan Ryan +6 more
doaj +1 more source
Influence of environmental conditions on the attenuation of ricin toxin on surfaces. [PDF]
PLoS ONE, 2018 Ricin is a highly-toxic compound derived from castor plant beans. Several incidents involving contamination of residences and buildings due to ricin production or dissemination have occurred in recent years.
Joseph P Wood +3 more
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