Results 1 to 10 of about 10,488 (210)
Autophagic Degradation Is Involved in Cell Protection against Ricin Toxin
Toxins, 2023 Autophagy is a complex and highly regulated degradative process, which acts as a survival pathway in response to cellular stress, starvation and pathogen infection.
Yu Wu +8 more
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Toxins, 2022 Ricin is a toxin which enters cells and depurinates an adenine base in the sarcin-ricin loop in the large ribosomal subunit, leading to the inhibition of protein translation and cell death.
Yan Ryan +6 more
doaj +1 more source
Influence of environmental conditions on the attenuation of ricin toxin on surfaces. [PDF]
PLoS ONE, 2018 Ricin is a highly-toxic compound derived from castor plant beans. Several incidents involving contamination of residences and buildings due to ricin production or dissemination have occurred in recent years.
Joseph P Wood +3 more
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Ricin Trafficking in Cells [PDF]
Toxins, 2015 The heterodimeric plant toxin ricin binds exposed galactosyls at the cell surface of target mammalian cells, and, following endocytosis, is transported in vesicular carriers to the endoplasmic reticulum (ER). Subsequently, the cell-binding B chain (RTB) and the catalytic A chain (RTA) are separated reductively, RTA embeds in the ER membrane and then ...
Robert A. Spooner, J. Michael Lord
openaire +3 more sources
Ricin crosses polarized human intestinal cells and intestines of ricin-gavaged mice without evident damage and then disseminates to mouse kidneys. [PDF]
PLoS ONE, 2013 Ricin is a potent toxin found in the beans of Ricinus communis and is often lethal for animals and humans when aerosolized or injected and causes significant morbidity and occasional death when ingested.
Alyssa D Flora +5 more
doaj +1 more source
Toxins, 2019 Ricin, a lethal toxin derived from castor oil beans, is a potential bio-threat due to its high availability and simplicity of preparation. Ricin is prepared according to simple recipes available on the internet, and was recently considered in terrorist ...
Anita Sapoznikov +8 more
doaj +1 more source
Ricin toxicokinetics and its sensitive detection in mouse sera or feces using immuno-PCR. [PDF]
PLoS ONE, 2010 Ricin (also called RCA-II or RCA(60)), one of the most potent toxins and documented bioweapons, is derived from castor beans of Ricinus communis. Several in vitro methods have been designed for ricin detection in complex food matrices in the event of ...
Xiaohua He +4 more
doaj +1 more source
Differential ER stress as a driver of cell fate following ricin toxin exposure
FASEB BioAdvances, 2022 Inhalation of trace amounts of ricin toxin, a plant‐derived ribosome‐inactivating protein, results in ablation of alveolar macrophages, widespread epithelial damage, and the onset of acute respiratory distress syndrome (ARDS). While ricin's receptors are
Claire Peterson‐Reynolds +1 more
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Role of Phospholipase A2 in Retrograde Transport of Ricin
Toxins, 2011 Ricin is a protein toxin classified as a bioterror agent, for which there are no known treatment options available after intoxication. It is composed of an enzymatically active A-chain connected by a disulfide bond to a cell binding B-chain.
Kirsten Sandvig +3 more
doaj +1 more source
Active Immunity Induced by Passive IgG Post-Exposure Protection against Ricin
Toxins, 2014 Therapeutic antibodies can confer an instant protection against biothreat agents when administered. In this study, intact IgG and F(ab’)2 from goat anti-ricin hyperimmune sera were compared for the protection against lethal ricin mediated intoxication ...
Charles Chen Hu +4 more
doaj +1 more source