Role of Phospholipase A2 in Retrograde Transport of Ricin
Toxins, 2011 Ricin is a protein toxin classified as a bioterror agent, for which there are no known treatment options available after intoxication. It is composed of an enzymatically active A-chain connected by a disulfide bond to a cell binding B-chain.
Kirsten Sandvig +3 more
doaj +1 more source
Differential ER stress as a driver of cell fate following ricin toxin exposure
FASEB BioAdvances, 2022 Inhalation of trace amounts of ricin toxin, a plant‐derived ribosome‐inactivating protein, results in ablation of alveolar macrophages, widespread epithelial damage, and the onset of acute respiratory distress syndrome (ARDS). While ricin's receptors are
Claire Peterson‐Reynolds +1 more
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Active Immunity Induced by Passive IgG Post-Exposure Protection against Ricin
Toxins, 2014 Therapeutic antibodies can confer an instant protection against biothreat agents when administered. In this study, intact IgG and F(ab’)2 from goat anti-ricin hyperimmune sera were compared for the protection against lethal ricin mediated intoxication ...
Charles Chen Hu +4 more
doaj +1 more source
The Possible Protective Effect of Alpha-Lipoic Acid against Acute Ricin-Induced Nephrotoxicity in Adult Male Albino Rats [PDF]
Ain Shams Journal of Forensic Medicine and Clinical Toxicology, 2018 Background: Ricin toxin is considered one of the most potent plant-derived toxins. It induces rapid and irreversible toxic effects through many mechanisms with special concern to inhibition of protein synthesis and oxidative stress resulting in cell ...
Ahmed Zaki +3 more
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The isolation and characterisation of temperature-dependent Ricin A chain molecules in Saccharomyces cerevisiae. [PDF]
, 2007 Ricin is a heterodimeric plant protein that is potently toxic to mammalian cells. Toxicity results from the catalytic depurination of eukaryotic ribosomes by ricin A chain (RTA) that follows toxin endocytosis to, and translocation across, the ...
Ladds, Graham +15 more
core +1 more source
Characterization of Ricin and R. communis Agglutinin Reference Materials
Toxins, 2015 Ricinus communis intoxications have been known for centuries and were attributed to the toxic protein ricin. Due to its toxicity, availability, ease of preparation, and the lack of medical countermeasures, ricin attracted interest as a potential ...
Sylvia Worbs +9 more
doaj +1 more source
Equal Neutralization Potency of Antibodies Raised against Abrin Subunits
Antibodies, 2020 Abrin and ricin are potent AB toxins, which are considered biological threats. To date, there are no approved treatments against abrin or ricin intoxications.
Yoav Gal +9 more
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POSSIBLE PROTECTIVE EFFECT OF ALPHA LIPOIC ACID AGAINST RICIN INDUCED HEPATOTOXICITY IN ADULT MALE ALBINO RATS [PDF]
The Egyptian Journal of Forensic Sciences and Applied Toxicology, 2016 Introduction: Ricin is one of the most potent and deadly plant toxins known. It induces oxidative stress and was exploited as a poison for bioterrorism due to its characters.
Naglaa Sarhan, Amira A. Wahdan
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The proteasome cap RPT5/Rpt5p subunit prevents aggregation of unfolded ricin A chain [PDF]
, 2013 The plant cytotoxin ricin enters mammalian cells by receptor-mediated endocytosis, undergoing retrograde transport to the endoplasmic reticulum (ER) where its catalytic A chain (RTA) is reductively separated from the holotoxin to enter the cytosol and ...
Spooner, Robert A. +12 more
core +1 more source
TRAIL (CD253) Sensitizes Human Airway Epithelial Cells to Toxin-Induced Cell Death
mSphere, 2018 Inhalation of ricin toxin is associated with the onset of acute respiratory distress syndrome (ARDS), characterized by hemorrhage, inflammatory exudates, and tissue edema, as well as the nearly complete destruction of the lung epithelium.
Yinghui Rong +4 more
doaj +1 more source