Results 21 to 30 of about 11,668 (212)
Purified Immunoglobulin F(ab′) 2 Protects Mice and Rhesus Monkeys against Lethal Ricin Intoxication
Zoonoses, 2023 Ricin is a highly toxic ribosome-inactivating lectin derived from castor beans. To date, no antidote is available to treat ricin-poisoned patients, and the development of a safe and effective antidote is urgently needed.
Jingjing Tian +16 more
doaj +1 more source
Acta Pharmaceutica Sinica B, 2020 Ricin is a highly toxic type 2 ribosome-inactivating protein (RIP) which is extracted from the seeds of castor beans. Ricin is considered a potential bioterror agent and no effective antidote for ricin exists so far.
Xu Zhao +7 more
doaj +1 more source
Toxins, 2022 Ricin is a toxin which enters cells and depurinates an adenine base in the sarcin-ricin loop in the large ribosomal subunit, leading to the inhibition of protein translation and cell death.
Yan Ryan +6 more
doaj +1 more source
Influence of environmental conditions on the attenuation of ricin toxin on surfaces. [PDF]
PLoS ONE, 2018 Ricin is a highly-toxic compound derived from castor plant beans. Several incidents involving contamination of residences and buildings due to ricin production or dissemination have occurred in recent years.
Joseph P Wood +3 more
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Ricin crosses polarized human intestinal cells and intestines of ricin-gavaged mice without evident damage and then disseminates to mouse kidneys. [PDF]
PLoS ONE, 2013 Ricin is a potent toxin found in the beans of Ricinus communis and is often lethal for animals and humans when aerosolized or injected and causes significant morbidity and occasional death when ingested.
Alyssa D Flora +5 more
doaj +1 more source
Ricin trafficking in plant and mammalian cells [PDF]
, 2011 Ricin is a heterodimeric plant protein that is potently toxic to mammalian and many other eukaryotic cells. It is synthesized and stored in the endosperm cells of maturing Ricinus communis seeds (castor beans).
Lord, Mike +3 more
core +1 more source
Toxins, 2019 Ricin, a lethal toxin derived from castor oil beans, is a potential bio-threat due to its high availability and simplicity of preparation. Ricin is prepared according to simple recipes available on the internet, and was recently considered in terrorist ...
Anita Sapoznikov +8 more
doaj +1 more source
Ricin toxicokinetics and its sensitive detection in mouse sera or feces using immuno-PCR. [PDF]
PLoS ONE, 2010 Ricin (also called RCA-II or RCA(60)), one of the most potent toxins and documented bioweapons, is derived from castor beans of Ricinus communis. Several in vitro methods have been designed for ricin detection in complex food matrices in the event of ...
Xiaohua He +4 more
doaj +1 more source
Differential ER stress as a driver of cell fate following ricin toxin exposure
FASEB BioAdvances, 2022 Inhalation of trace amounts of ricin toxin, a plant‐derived ribosome‐inactivating protein, results in ablation of alveolar macrophages, widespread epithelial damage, and the onset of acute respiratory distress syndrome (ARDS). While ricin's receptors are
Claire Peterson‐Reynolds +1 more
doaj +1 more source
Ricin Trafficking in Cells [PDF]
Toxins, 2015 The heterodimeric plant toxin ricin binds exposed galactosyls at the cell surface of target mammalian cells, and, following endocytosis, is transported in vesicular carriers to the endoplasmic reticulum (ER). Subsequently, the cell-binding B chain (RTB) and the catalytic A chain (RTA) are separated reductively, RTA embeds in the ER membrane and then ...
Robert A. Spooner, J. Michael Lord
openaire +3 more sources