Results 11 to 20 of about 21,600 (215)

Cytosolic chaperones influence the fate of a toxin dislocated from the endoplasmic reticulum [PDF]

, 2008
The plant cytotoxin ricin enters target mammalian cells by receptor-mediated endocytosis and undergoes retrograde transport to the endoplasmic reticulum (ER).
R. A. Spooner, P. J. Hart, J. P. Cook, P. Pietroni, C. Rogon, J. Hohfeld, L. M. Roberts, J. M. Lord, Brodsky, Meusser, Spooner, Wesche, Argent, van Deurs, Rapak, Wales, Meacham, Brodsky, Hudson, Roe, Lawson, Argent, Savino, Chaddock, Chen, Luders, H  hfeld, Urushitani, Younger, Arndt, Nakatsukasa, Nakatsukasa, Hundley   +32 more
core   +4 more sources

RIPpore: A Novel Host-Derived Method for the Identification of Ricin Intoxication through Oxford Nanopore Direct RNA Sequencing

Toxins, 2022
Ricin is a toxin which enters cells and depurinates an adenine base in the sarcin-ricin loop in the large ribosomal subunit, leading to the inhibition of protein translation and cell death.
Yan Ryan, Abbie Harrison, Hannah Trivett, Catherine Hartley, Jonathan David, Graeme C. Clark, Julian A. Hiscox   +6 more
doaj   +1 more source

Ricin crosses polarized human intestinal cells and intestines of ricin-gavaged mice without evident damage and then disseminates to mouse kidneys. [PDF]

PLoS ONE, 2013
Ricin is a potent toxin found in the beans of Ricinus communis and is often lethal for animals and humans when aerosolized or injected and causes significant morbidity and occasional death when ingested.
Alyssa D Flora, Louise D Teel, Mark A Smith, James F Sinclair, Angela R Melton-Celsa, Alison D O'Brien   +5 more
doaj   +1 more source

A double safety lock tumor-specific device for suicide gene therapy in breast cancer [PDF]

, 2020
Producción CientíficaThe complexity and continuous evolution of cancer make the design of novel strategies of treatment a constant challenge in biomedicine.
Arias Vallejo, Francisco Javier, Girotti, Alessandra, Muñoz Martínez, Raquel, Piña Lancho, María Jesús, Rodríguez Cabello, José Carlos, Serrano, Sofía   +5 more
core   +2 more sources

Ricin trafficking in plant and mammalian cells [PDF]

, 2011
Ricin is a heterodimeric plant protein that is potently toxic to mammalian and many other eukaryotic cells. It is synthesized and stored in the endosperm cells of maturing Ricinus communis seeds (castor beans).
Lord, Mike, Spooner, Robert A.
core   +2 more sources

Intramuscular Ricin Poisoning of Mice Leads to Widespread Damage in the Heart, Spleen, and Bone Marrow

Toxins, 2019
Ricin, a lethal toxin derived from castor oil beans, is a potential bio-threat due to its high availability and simplicity of preparation. Ricin is prepared according to simple recipes available on the internet, and was recently considered in terrorist ...
Anita Sapoznikov, Amir Rosner, Reut Falach, Yoav Gal, Moshe Aftalion, Yentl Evgy, Ofir Israeli, Tamar Sabo, Chanoch Kronman   +8 more
doaj   +1 more source

Ricin Antibodies’ Neutralizing Capacity against Different Ricin Isoforms and Cultivars

Toxins, 2021
Ricin, a highly toxic protein from Ricinus communis, is considered a potential biowarfare agent. Despite the many data available, no specific treatment has yet been approved.
Maria Lucia Orsini Delgado, Arnaud Avril, Julie Prigent, Julie Dano, Audrey Rouaix, Sylvia Worbs, Brigitte G. Dorner, Clémence Rougeaux, François Becher, François Fenaille, Sandrine Livet, Hervé Volland, Jean-Nicolas Tournier, Stéphanie Simon   +13 more
doaj   +1 more source

Ricin toxicokinetics and its sensitive detection in mouse sera or feces using immuno-PCR. [PDF]

PLoS ONE, 2010
Ricin (also called RCA-II or RCA(60)), one of the most potent toxins and documented bioweapons, is derived from castor beans of Ricinus communis. Several in vitro methods have been designed for ricin detection in complex food matrices in the event of ...
Xiaohua He, Stephanie McMahon, Thomas D Henderson, Stephen M Griffey, Luisa W Cheng   +4 more
doaj   +1 more source

The proteasome cap RPT5/Rpt5p subunit prevents aggregation of unfolded ricin A chain [PDF]

, 2013
The plant cytotoxin ricin enters mammalian cells by receptor-mediated endocytosis, undergoing retrograde transport to the endoplasmic reticulum (ER) where its catalytic A chain (RTA) is reductively separated from the holotoxin to enter the cytosol and ...
Afshar, Allen, Argent, Bays, Bellisola, Blum, Braun, Brodsky, Carvalho, Cascio, Craiu, David M. Roberts, Deeks, Elkabetz, Endo, Fiani, Fleming, Fu, Gallastegui, Giodini, Groll, Hartley, Hazes, Heiligenstein, Heinemeyer, Hendil, Holmberg, Hudson, Husnjak, J. Michael Lord, Jarosch, Jin, Jonathan P. Cook, Kohler, Lam, Li, Li, Lipson, Lundgren, Lynne M. Roberts, May, Mayerhofer, Nishi Vasisht, Paola Pietroni, Rabinovich, Rasmus Hartmann-Petersen, Redmann, Robert A. Spooner, Rubin, Sandvig, Schreiner, Sokolowska, Spooner, Spooner, Spooner, Spooner, Strickland, Surjit, Unno, van Nocker, Wesche, Ye   +61 more
core   +2 more sources

Differential ER stress as a driver of cell fate following ricin toxin exposure

FASEB BioAdvances, 2022
Inhalation of trace amounts of ricin toxin, a plant‐derived ribosome‐inactivating protein, results in ablation of alveolar macrophages, widespread epithelial damage, and the onset of acute respiratory distress syndrome (ARDS). While ricin's receptors are
Claire Peterson‐Reynolds, Nicholas J. Mantis   +1 more
doaj   +1 more source