Antibodies, 2013 Ricin is a type II ribosome inactivating protein (RIP) isolated from castor beans. Its high toxicity classifies it as a possible biological weapon. On the other hand, ricin linked to specific monoclonal antibodies or used in other conjugates has powerful
Monika Słomińska-Wojewódzka +1 more
exaly +4 more sources
Ricin Antibodies’ Neutralizing Capacity against Different Ricin Isoforms and Cultivars [PDF]
Toxins, 2021 Ricin, a highly toxic protein from Ricinus communis, is considered a potential biowarfare agent. Despite the many data available, no specific treatment has yet been approved.
Maria Lucia Orsini Delgado +13 more
doaj +2 more sources
Rational development of an mRNA antibody cocktail with extended therapeutic window against ricin intoxication [PDF]
Applied Microbiology and BiotechnologyRicin, a highly toxic protein derived from Ricinus communis, is recognized as a biological threat due to its high toxicity and the absence of approved specific antidotes.
Mei Wu +14 more
doaj +2 more sources
Differential Thermal Inactivation Enables Simultaneous Quantitation of Ricin and Abrin [PDF]
ToxinsRicin and abrin are highly lethal Type II ribosome-inactivating proteins. They depurinate the same site of the 28S rRNA to inhibit protein synthesis. Consequently, standard molecular-level activity assays used to detect the toxic activity of ricin or ...
Woo-Hyeon Jeong
doaj +2 more sources
A Monoclonal Antibody with a High Affinity for Ricin Isoforms D and E Provides Strong Protection against Ricin Poisoning [PDF]
ToxinsRicin is a highly potent toxin that has been used in various attempts at bioterrorism worldwide. Although a vaccine for preventing ricin poisoning (RiVax™) is in clinical development, there are currently no commercially available prophylaxis or ...
Loïs Lequesne +11 more
doaj +2 more sources
Ricin Toxicity to Intestinal Cells Leads to Multiple Cell Death Pathways Mediated by Oxidative Stress [PDF]
ToxinsRicin, a type 2 ribosome-inactivating protein, is a lethal toxin found in castor bean seeds. Although the systemic toxicity of ricin has been extensively studied, its localized effect on the gastrointestinal tract remains a critical concern, particularly
Francesco Biscotti +5 more
doaj +2 more sources
Understanding Ricin from a Defensive Viewpoint
Toxins, 2011 The toxin ricin has long been understood to have potential for criminal activity and there has been concern that it might be used as a mass-scale weapon on a military basis for at least two decades.
Gareth D. Griffiths
doaj +2 more sources
Methods for nanoparticle labeling of ricin and effect on toxicity [PDF]
, 2009 The unique optical properties associated with nanostructured materials that support the excitation of surface plasmons offer many new opportunities for the enhanced optical investigation of biological materials that pose a security threat. In particular,
Jun Yu +9 more
core +4 more sources
Spiroplasma Are Protective Heritable Symbionts With Low Physiological Impact in the Drosophilid Fly Zaprionus kolodkinae. [PDF]
Environ Microbiol RepZaprionus kolodkinae flies carry a maternally inherited ixodetis clade Spiroplasma that protects its host against wasp attack but has low overall physiological impact. Genome analysis presented a set of known symbiosis‐relevant effectors, and one encoding—a ricin B domain protein—that is novel to this Spiroplasma genome.
Alamer N +5 more
europepmc +2 more sources
Autophagic Degradation Is Involved in Cell Protection against Ricin Toxin
Toxins, 2023 Autophagy is a complex and highly regulated degradative process, which acts as a survival pathway in response to cellular stress, starvation and pathogen infection.
Yu Wu +8 more
doaj +1 more source