Results 31 to 40 of about 10,488 (210)

Folding-competent and folding-defective forms of Ricin A chain have different fates following retrotranslocation from the endoplasmic reticulum [PDF]

, 2010
We report that a toxic polypeptide retaining the potential to refold upon dislocation from the endoplasmic reticulum (ER) to the cytosol (ricin A chain; RTA) and a misfolded version that cannot (termed RTAΔ), follow ER-associated degradation (ERAD ...
Ladds, Graham, Manfred J. Schmitt, Robert A. Spooner, Stuart C. H. Allen, Schmitt, Manfred J., Shuyu Li, Christopher P. Guise, Lord, J M, Allen, Stuart C. H., Li, Shuyu, Roberts, L. M. (Lynne M.), Allen, Stuart C H, Schnöder, Tina, Spooner, R A, Spooner, Robert A., Ladds, G, Roberts, R M, Tina Schnöder, Guise, C P, Schmitt, M J, Guise, Christopher P., Graham Ladds, Lord, Mike, Lynne M. Roberts, J. Michael Lord, Li, S, Schnoder, T   +26 more
core   +1 more source

Equal Neutralization Potency of Antibodies Raised against Abrin Subunits

Antibodies, 2020
Abrin and ricin are potent AB toxins, which are considered biological threats. To date, there are no approved treatments against abrin or ricin intoxications.
Yoav Gal, Anita Sapoznikov, Reut Falach, Ohad Mazor, Ron Alcalay, Eytan Elhanany, Moshe Aftalion, Sharon Ehrlich, Chanoch Kronman, Tamar Sabo   +9 more
doaj   +1 more source

POSSIBLE PROTECTIVE EFFECT OF ALPHA LIPOIC ACID AGAINST RICIN INDUCED HEPATOTOXICITY IN ADULT MALE ALBINO RATS [PDF]

The Egyptian Journal of Forensic Sciences and Applied Toxicology, 2016
Introduction: Ricin is one of the most potent and deadly plant toxins known. It induces oxidative stress and was exploited as a poison for bioterrorism due to its characters.
Naglaa Sarhan, Amira A. Wahdan
doaj   +1 more source

TRAIL (CD253) Sensitizes Human Airway Epithelial Cells to Toxin-Induced Cell Death

mSphere, 2018
Inhalation of ricin toxin is associated with the onset of acute respiratory distress syndrome (ARDS), characterized by hemorrhage, inflammatory exudates, and tissue edema, as well as the nearly complete destruction of the lung epithelium.
Yinghui Rong, Jennifer Westfall, Dylan Ehrbar, Timothy LaRocca, Nicholas J. Mantis   +4 more
doaj   +1 more source

Eeyarestatin 1 interferes with both retrograde and anterograde intracellular trafficking pathways [PDF]

, 2011
Background: The small molecule Eeyarestatin I (ESI) inhibits the endoplasmic reticulum (ER)-cytosol dislocation and subsequent degradation of ERAD (ER associated protein degradation) substrates.
Aletrari, Mina-Olga, Roger Whitehead, Helen Williams, Whitehead, Roger C., Robert A. Spooner, Flitsch, Sabine L., Swanton, Eileithyia, Stephen High, Pietroni, Paola, Eileithyia Swanton, Whitehead, Roger, Vidya Pawar, Sabine L. Flitsch, Sabine L Flitsch, Paola Pietroni, High, Stephen; id_orcid, J Michael Lord, Spooner, Robert A., Lord, J. Michael, McKibbin, Craig, Pawar, Vidya, Williams, Helen, Lord, Mike, Mina-Olga Aletrari, Robert A Spooner, Craig McKibbin, High, Stephen, J. Michael Lord, Aletrari, Mina Olga   +28 more
core   +1 more source

Ricin Toxins [PDF]

, 2020
The plant toxin ricin is one of the most potent and lethal substances known. Due to its wide availability and the ease of production, ricin has been exploited as an agent of bioterrorism and biological warfare and is classified as a level B threat.

core   +1 more source

Immunochromatography Detection of Ricin in Environmental and Biological Samples

Nano Biomedicine and Engineering, 2011
Ricin has been considered as a potential agent of biological warfare or terrorist attack. This work is aimed to develop and evaluate a rapid test strip for the assay of ricin in environmental and biological samples.
Junhua Wu, Yuxia Wang, Peiyuan Jia, Chenyu Wang, Yu Zhao, Hui Peng, Wenqing Wei, Hua Li   +7 more
doaj   +1 more source

Generation of Highly Efficient Equine-Derived Antibodies for Post-Exposure Treatment of Ricin Intoxications by Vaccination with Monomerized Ricin

Toxins, 2018
Ricin, a highly lethal toxin derived from the seeds of Ricinus communis (castor beans) is considered a potential biological threat agent due to its high availability, ease of production, and to the lack of any approved medical countermeasure against ...
Reut Falach, Anita Sapoznikov, Ron Alcalay, Moshe Aftalion, Sharon Ehrlich, Arik Makovitzki, Avi Agami, Avishai Mimran, Amir Rosner, Tamar Sabo, Chanoch Kronman, Yoav Gal   +11 more
doaj   +1 more source

Retrograde transport pathways utilised by viruses and protein toxins [PDF]

, 2006
A model has been presented for retrograde transport of certain toxins and viruses from the cell surface to the ER that suggests an obligatory interaction with a glycolipid receptor at the cell surface. Here we review studies on the ER trafficking cholera
J Michael Lord, Lord, Mike, Spooner, Robert A., Smith, Daniel C., Daniel C Smith, Roberts, L. M. (Lynne M.), Andrew J Easton, Easton, A. J. (Andrew J.), Robert A Spooner, Lynne M Roberts   +9 more
core   +1 more source

Methods for nanoparticle labeling of ricin and effect on toxicity

, 2009
The unique optical properties associated with nanostructured materials that support the excitation of surface plasmons offer many new opportunities for the enhanced optical investigation of biological materials that pose a security threat. In particular,
Jun Yu, Graham, Duncan, Christopher D. Lindsay, Nativo, Paola, Alastair W. Wark, Duncan Graham, Wark, Alastair, Paola Nativo, Yu, Jun, Lindsay, C. D.   +9 more
core   +1 more source