Results 31 to 40 of about 11,668 (212)

RNAi screening of Drosophila (Sophophora) melanogaster S2 cells for ricin sensitivity and resistance [PDF]

, 2011
The ribosome-inhibiting toxin ricin binds exposed β1→4 linked galactosyls on multiple glycolipids and glycoproteins on the cell surface of most eukaryotic cells. After endocytosis, internal cell trafficking is promiscuous, with only a small proportion of
Omar, Mahmoud M., Spooner, Robert A., Robert A. Spooner, Kevin G. Moffat, Sean T. Sweeney, De, Antara, Pawar, Vidya, Lord, Mike, Laura Briggs, Antara De, Lynne M. Roberts, Briggs, Laura, Roberts, L. M. (Lynne M.), Moffat, Kevin G., Vidya Pawar, Sweeney, Sean T., Mahmoud M. Omar, J. Michael Lord   +17 more
core   +1 more source

Role of Phospholipase A2 in Retrograde Transport of Ricin

Toxins, 2011
Ricin is a protein toxin classified as a bioterror agent, for which there are no known treatment options available after intoxication. It is composed of an enzymatically active A-chain connected by a disulfide bond to a cell binding B-chain.
Kirsten Sandvig, Anne Berit Dyve Lingelem, Anne-Grethe Myrann, Tove Irene Klokk   +3 more
doaj   +1 more source

Active Immunity Induced by Passive IgG Post-Exposure Protection against Ricin

Toxins, 2014
Therapeutic antibodies can confer an instant protection against biothreat agents when administered. In this study, intact IgG and F(ab’)2 from goat anti-ricin hyperimmune sera were compared for the protection against lethal ricin mediated intoxication ...
Charles Chen Hu, Junfei Yin, Damon Chau, John W. Cherwonogrodzky, Wei-Gang Hu   +4 more
doaj   +1 more source

The Possible Protective Effect of Alpha-Lipoic Acid against Acute Ricin-Induced Nephrotoxicity in Adult Male Albino Rats [PDF]

Ain Shams Journal of Forensic Medicine and Clinical Toxicology, 2018
Background: Ricin toxin is considered one of the most potent plant-derived toxins. It induces rapid and irreversible toxic effects through many mechanisms with special concern to inhibition of protein synthesis and oxidative stress resulting in cell ...
Ahmed Zaki, Sadika Tawfik, Marwa Shahin, Doaa Elgharbawy   +3 more
doaj   +1 more source

Equal Neutralization Potency of Antibodies Raised against Abrin Subunits

Antibodies, 2020
Abrin and ricin are potent AB toxins, which are considered biological threats. To date, there are no approved treatments against abrin or ricin intoxications.
Yoav Gal, Anita Sapoznikov, Reut Falach, Ohad Mazor, Ron Alcalay, Eytan Elhanany, Moshe Aftalion, Sharon Ehrlich, Chanoch Kronman, Tamar Sabo   +9 more
doaj   +1 more source

POSSIBLE PROTECTIVE EFFECT OF ALPHA LIPOIC ACID AGAINST RICIN INDUCED HEPATOTOXICITY IN ADULT MALE ALBINO RATS [PDF]

The Egyptian Journal of Forensic Sciences and Applied Toxicology, 2016
Introduction: Ricin is one of the most potent and deadly plant toxins known. It induces oxidative stress and was exploited as a poison for bioterrorism due to its characters.
Naglaa Sarhan, Amira A. Wahdan
doaj   +1 more source

The proteasome cap RPT5/Rpt5p subunit prevents aggregation of unfolded ricin A chain [PDF]

, 2013
The plant cytotoxin ricin enters mammalian cells by receptor-mediated endocytosis, undergoing retrograde transport to the endoplasmic reticulum (ER) where its catalytic A chain (RTA) is reductively separated from the holotoxin to enter the cytosol and ...
Spooner, Robert A., Roberts, David M, Roberts, Lynne M, Lord, J Michael, Cook, Jonathan P., Pietroni, Paola, Roberts, David M., Lord, Mike, Roberts, L. M. (Lynne M.), Spooner, Robert A, Vasisht, Nishi, Hartmann-Petersen, Rasmus, Cook, Jonathan P   +12 more
core   +1 more source

The isolation and characterisation of temperature-dependent Ricin A chain molecules in Saccharomyces cerevisiae. [PDF]

, 2007
Ricin is a heterodimeric plant protein that is potently toxic to mammalian cells. Toxicity results from the catalytic depurination of eukaryotic ribosomes by ricin A chain (RTA) that follows toxin endocytosis to, and translocation across, the ...
Ladds, Graham, Moffat, K G, Allen, Stuart C H, Fulop, V, Moore, Katherine A. H., Marsden, Catherine J., Marsden, C J, Ladds, G, Roberts, L M, Lord, Mike, Lord, J M, Allen, Stuart C. H., Roberts, L. M. (Lynne M.), Moffat, Kevin G., Fülöp, Vilmos, Moore, K A H   +15 more
core   +1 more source

Folding-competent and folding-defective forms of Ricin A chain have different fates following retrotranslocation from the endoplasmic reticulum [PDF]

, 2010
We report that a toxic polypeptide retaining the potential to refold upon dislocation from the endoplasmic reticulum (ER) to the cytosol (ricin A chain; RTA) and a misfolded version that cannot (termed RTAΔ), follow ER-associated degradation (ERAD ...
Ladds, Graham, Manfred J. Schmitt, Robert A. Spooner, Stuart C. H. Allen, Schmitt, Manfred J., Shuyu Li, Christopher P. Guise, Lord, J M, Allen, Stuart C. H., Li, Shuyu, Roberts, L. M. (Lynne M.), Allen, Stuart C H, Schnöder, Tina, Spooner, R A, Spooner, Robert A., Ladds, G, Roberts, R M, Tina Schnöder, Guise, C P, Schmitt, M J, Guise, Christopher P., Graham Ladds, Lord, Mike, Lynne M. Roberts, J. Michael Lord, Li, S, Schnoder, T   +26 more
core   +1 more source

Eeyarestatin 1 interferes with both retrograde and anterograde intracellular trafficking pathways [PDF]

, 2011
Background: The small molecule Eeyarestatin I (ESI) inhibits the endoplasmic reticulum (ER)-cytosol dislocation and subsequent degradation of ERAD (ER associated protein degradation) substrates.
Aletrari, Mina-Olga, Roger Whitehead, Helen Williams, Whitehead, Roger C., Robert A. Spooner, Flitsch, Sabine L., Swanton, Eileithyia, Stephen High, Pietroni, Paola, Eileithyia Swanton, Whitehead, Roger, Vidya Pawar, Sabine L. Flitsch, Sabine L Flitsch, Paola Pietroni, High, Stephen; id_orcid, J Michael Lord, Spooner, Robert A., Lord, J. Michael, McKibbin, Craig, Pawar, Vidya, Williams, Helen, Lord, Mike, Mina-Olga Aletrari, Robert A Spooner, Craig McKibbin, High, Stephen, J. Michael Lord, Aletrari, Mina Olga   +28 more
core   +2 more sources