Results 41 to 50 of about 11,668 (212)
, 2020 The plant toxin ricin is one of the most potent and lethal substances known. Due to its wide availability and the ease of production, ricin has been exploited as an agent of bioterrorism and biological warfare and is classified as a level B threat.
core +1 more source
Retrograde transport pathways utilised by viruses and protein toxins [PDF]
, 2006 A model has been presented for retrograde transport of certain toxins and viruses from the cell surface to the ER that suggests an obligatory interaction with a glycolipid receptor at the cell surface. Here we review studies on the ER trafficking cholera
J Michael Lord +9 more
core +1 more source
Advanced Science, EarlyView.Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu +11 more
wiley +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT Moringa oleifera Lam. seeds contain WSMoL, a lectin previously studied for toxicity and pharmacological effects. In this study, we investigated WSMoL (10, 25, or 50 mg/kg i.p.) for acute and 14‐day repeated‐dose toxicity, as well as genotoxicity, in Swiss mice.
Alícia Natalie Silva dos Santos +10 more
wiley +1 more source
A case of accidental Ricin poisoning [PDF]
, 2004 A case report of accidental, mild ricin poisoning by ingestion of ten Castor beans by a 70 year old man. The clinical presentation is followed by a discussion about the toxicity of ricin, its use and misuse and the contrast between the toxicity of pure ...
Despott, Edward, Cachia, Mario J.
core
Targeting ricin to the ribosome [PDF]
Toxicon, 2013 The plant toxin ricin is highly toxic for mammalian cells and is of concern for bioterrorism. Ricin belongs to a family of functionally related toxins, collectively referred to as ribosome inactivating proteins (RIPs), which disable ribosomes and halt protein synthesis. Currently there are no specific antidotes against ricin or related RIPs.
Kerrie L, May +2 more
openaire +2 more sources
Mass Spectrometry Reviews, EarlyView.ABSTRACT Identification of a chemical agent yields insights into its physicochemical properties. By examining the intrinsic characteristics and environment of a compound, information about its history can be gathered. The main objective of authentication/forensic approaches to chemicals is to trace the history of the compound's origin, regardless of ...
Carla Orlandi +6 more
wiley +1 more source
AVIDbase: A biologically accurate structural dataset of nanobody‐antigen complexes
Protein Science, Volume 35, Issue 9, September 2026.Abstract Accurate structural data in a standardized format is one of the key factors behind the success of machine learning (ML)‐based methods for protein design and structure prediction. However, their application to nanobody‐antigen complexes has lower success rates compared to globular protein complexes, partly due to the limited amount of high ...
Tadej Medved +3 more
wiley +1 more source
Syntaxin 16 and syntaxin 5 are required for efficient retrograde transport of several exogenous and endogenous cargo proteins [PDF]
, 2007 Retrograde transport allows proteins and lipids to leave the endocytic pathway to reach other intracellular compartments, such as trans-Golgi network (TGN)/Golgi membranes, the endoplasmic reticulum and, in some instances, the cytosol. Here, we have used
Falguières, Thomas +15 more
core +1 more source
ISOLATION OF CRYSTALLINE RICIN [PDF]
Journal of General Physiology, 1948 A toxic crystalline protein has been isolated from crude extracts of castor bean meal. Ultracentrifuge and electrophoresis tests show the crystalline protein to become fairly homogeneous after three or four crystallizations. This is also confirmed by toxicity measurements.
M, KUNITZ, M R, McDONALD
openaire +2 more sources