Results 61 to 70 of about 11,668 (212)

Ricin Poisoning [PDF]

JAMA, 2005
The recent discoveries of ricin, a deadly biologic toxin, at a South Carolina postal facility, a White House mail facility, and a US senator's office has raised concerns among public health officials, physicians, and citizens. Ricin is one of the most potent and lethal substances known, particularly when inhaled.
Jennifer, Audi, Martin, Belson, Manish, Patel, Joshua, Schier, John, Osterloh   +4 more
openaire   +2 more sources

Chemical Characterization and In Vivo Safety Assessment of Aqueous Extract From Anacardium occidentale L. (Anacardiaceae) Leaves

Chemistry &Biodiversity, Volume 23, Issue 7, July 2026.
Anacardium occidentale leaf aqueous extract showed rich polyphenolic composition, including flavonoids, tannins, and phenolic acids. Acute toxicity in mice revealed no mortality or adverse effects, with LD50 >2000 mg/kg and GHS Class 5. Genotoxicity assays were negative, supporting safety and potential phytopharmaceutical development, pending chronic ...
Elinado Francisco de Lima Bento, Caio Everton Nunes da Silva, Talita Giselly dos Santos Souza, Camylla Janiele Lucas Tenório, Natanael Teles Ramos de Lima, Cristiano Aparecido Chagas, José Maria Barbosa Filho, Magda Rhayanny Assunção Ferreira, Luiz Alberto Lira Soares, Samuel Paulo Cibulski, Alisson Macário de Oliveira, Thiago Henrique Napoleão   +11 more
wiley   +1 more source

Two kinds of anti-ricin antibody and ricin interaction evaluated by biosensor based on imaging ellipsometry

, 2011
In order to meet the requirements of antibody comparison and evaluation, the optimization for the surface modification, ligand immobilization, unspecific blocking and ligand receptor interaction condition is introduced to the biosensor based on imaging ...
牛宇, Yan XY, 靳刚, Jin, G (reprint author), Chinese Acad Sci, NML, Inst Mech, 15 Bei Si Huan W Rd, Beijing 100190, Peoples R China, Zhuang J, 刘丽   +5 more
core   +1 more source

Pairing Alpaca and Llama-Derived Single Domain Antibodies to Enhance Immunoassays for Ricin

Antibodies, 2017
Previously, our group isolated and evaluated anti-ricin single domain antibodies (sdAbs) derived from llamas, engineered them to further increase their thermal stability, and utilized them for the development of sensitive immunoassays. In work focused on
Kendrick B. Turner, Sabrina Hardy, Jinny L. Liu, Dan Zabetakis, P. Audrey Brozozog Lee, Ellen R. Goldman, George P. Anderson   +6 more
doaj   +1 more source

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, Volume 13, Issue 32, 9 June 2026.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

Edulitin 2, a Ribotoxin‐Like Protein From Boletus edulis That Triggers Apoptosis in Colon Cancer Cells While Preserving the Integrity of the Intestinal Microbiota

eFood, Volume 7, Issue 3, June 2026.
Edulitin 2 is a ribotoxin‐like protein exhibiting a potent antiproliferative activity towards Caco‐2 and HT29 cells by programmed cell death. However, edulitin 2 does not affect gut microbiota growth, despite damaging fungal ribosomes. ABSTRACT Porcini (Boletus edulis Bull.) are a reservoir of pharmacological biomolecules with health‐promoting ...
Massimo Bortolotti, Sara Ragucci, Federica Falà, Anella Saggese, Francesco Biscotti, Ylenia De Luca, Nicola Landi, Paolo V. Pedone, Andrea Bolognesi, Ezio Ricca, Letizia Polito, Antimo Di Maro   +11 more
wiley   +1 more source

Intracellular Transport and Cytotoxicity of the Protein Toxin Ricin

Toxins, 2019
Ricin can be isolated from the seeds of the castor bean plant (Ricinus communis). It belongs to the ribosome-inactivating protein (RIP) family of toxins classified as a bio-threat agent due to its high toxicity, stability and availability.
Natalia Sowa-Rogozińska, Hanna Sominka, Jowita Nowakowska-Gołacka, Kirsten Sandvig, Monika Słomińska-Wojewódzka   +4 more
doaj   +1 more source

Establishment of a Novel Oral Murine Model of Ricin Intoxication and Efficacy Assessment of Ovine Ricin Antitoxins

Toxins, 2020
Ricin, produced from the castor beans of Ricinus communis, is a cytotoxin that exerts its action by inactivating ribosomes and causing cell death. Accidental (e.g., ingestion of castor beans) and/or intentional (e.g., suicide) exposure to ricin through ...
Sarah J. Whitfield, Debbie B. Padgen, Simon Knight, Robert J. Gwyther, Jane L. Holley, Graeme C. Clark, A. Christopher Green   +6 more
doaj   +1 more source

Isolation of Anti-Ricin Protective Antibodies Exhibiting High Affinity from Immunized Non-Human Primates

Toxins, 2016
Ricin, derived from the castor bean plant Ricinus communis, is one of the most potent and lethal toxins known, against which there is no available antidote.
Tal Noy-Porat, Ronit Rosenfeld, Naomi Ariel, Eyal Epstein, Ron Alcalay, Anat Zvi, Chanoch Kronman, Arie Ordentlich, Ohad Mazor   +8 more
doaj   +1 more source

Hydroxyl radical footprinting modification reveals an intradomain communication pathway in EFL1 disrupted by a Shwachman‐Diamond syndrome‐associated mutation

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Shwachman‐Diamond syndrome (SDS) is a rare genetic disorder characterized by pancreatic insufficiency and neutropenia. While most cases are linked to mutations in the SBDS gene, some involve mutations in the GTPase EFL1. This protein works with SBDS to release the anti‐association factor eIF6 from the 60S ribosomal subunit during ribosome ...
Jonathan A. Zúñiga‐Domínguez, Rohit Jain, Martín González‐Andrade, Erik R. Farquhar, Mark R. Chance, Abril Gijsbers, Nuria Sánchez‐Puig   +6 more
wiley   +1 more source