Results 81 to 90 of about 21,600 (215)

Recommended Mass Spectrometry-Based Strategies to Identify Ricin-Containing Samples

Toxins, 2015
Ricin is a protein toxin produced by the castor bean plant (Ricinus communis) together with a related protein known as R. communis agglutinin (RCA120). Mass spectrometric (MS) assays have the capacity to unambiguously identify ricin and to detect ricin’s
Suzanne R. Kalb, David M. Schieltz, François Becher, Crister Astot, Sten-Åke Fredriksson, John R. Barr   +5 more
doaj   +1 more source

From structural to functional glycomics: core substitutions as molecular switches for shape and lectin affinity of N-glycans [PDF]

, 2009
Glycan epitopes of cellular glycoconjugates act as versatile biochemical signals (sugar coding). Here, we test the hypothesis that the common N-glycan modifications by core fucosylation and introduction of the bisecting N-acetylglucosamine moiety have ...
André, Sabine, Gabius, Hans-Joachim, Kojima, Shuji, Kozar, Tibor, Unverzagt, Carlo   +4 more
core   +1 more source

CDG due to Defective Membrane Transporters: Update

Journal of Inherited Metabolic Disease, Volume 49, Issue 1, January 2026.
ABSTRACT Congenital disorders of glycosylation are genetic defects in the glycoprotein and glycolipid glycan assembly and attachment. Some 200 CDG have been reported since the first clinical description in 1980. Most CDG are enzymatic deficiencies, but 13 (6.5%) are defects in the ER, Golgi apparatus (GA), and plasma membrane transporters.
D. Quelhas, C. R. Ferreira, J. Jaeken
wiley   +1 more source

Real-time cytotoxicity assay for rapid and sensitive detection of ricin from complex matrices.

PLoS ONE, 2012
BackgroundIn the context of a potential bioterrorist attack sensitive and fast detection of functionally active toxins such as ricin from complex matrices is necessary to be able to start timely countermeasures.
Diana Pauly, Sylvia Worbs, Sebastian Kirchner, Olena Shatohina, Martin B Dorner, Brigitte G Dorner   +5 more
doaj   +1 more source

The Role of Scientific Discovery in the Establishment of the First Biological Weapons Programmes [PDF]

, 2005
YesThis report addresses the scientific and technological discoveries in the biological sciences that enabled the early interest in biological warfare to move from hurling infected corpses into enemy cities in ancient times, through use of small cultures
Davison, N.
core  

Immunomagnetic t-lymphocyte depletion (ITLD) of rat bone marrow using OX-19 monoclonal antibody [PDF]

, 1989
Graft versus host disease (GVHD) may be abrogated and host survival prolonged by in vitro depletion of T lymphocytes from bone marrow (BM) prior to allotransplantation. Using a mouse anti-rat pan T-lymphocyte monoclonal antibody (0×19) bound to monosized,
A. Pascualone, A.L. Hoffman, B.F. Banner, Barclay A, Berenson R J, Beschorner W E, Bril H, D.G. Sheahan, D.V. Cramer, Dallman M J, Elkins W L, Farnsworth A, Filipovich A H, Kvalheim G, L. Makowka, Lubaroff D M, Martin P J, Monchik G J, Oaks M K, P. Rettinger, Prentice H G, Reisner Y, Rodt H, Slavin R E, T.E. Starzl, Thtschka P J, Tsoi M-S, Van Bekkum D W, Vartdal F, Waldman H, X. Cai   +30 more
core   +1 more source

Chromosome‐level genome assembly of the photobiont microalga Trebouxia sp. ‘A48’ from the lichen Xanthoria parietina

New Phytologist, Volume 249, Issue 2, Page 1036-1052, January 2026.
Summary Lichens are symbiotic assemblies consisting of multiple organisms, chiefly a fungus and a photosynthetic microorganism, or photobiont. Among diverse photobionts, the most prevalent is the chlorophyte alga Trebouxia. We produced a chromosome‐level assembly of Trebouxia sp. ‘A48’, a photobiont of Xanthoria parietina. The genome was assembled into
Gulnara Tagirdzhanova, Jasper Raistrick, Nicholas J. Talbot   +2 more
wiley   +1 more source

Antibody/doxycycline combined therapy for pulmonary ricinosis: Attenuation of inflammation improves survival of ricin-intoxicated mice

Toxicology Reports, 2014
Ricin, a highly toxic plant-derived toxin, is considered a potential weapon in biological warfare due to its high availability and ease of preparation. Pulmonary exposure to ricin results in the generation of an acute edematous inflammation followed by ...
Yoav Gal, Ohad Mazor, Ron Alcalay, Nehama Seliger, Moshe Aftalion, Anita Sapoznikov, Reut Falach, Chanoch Kronman, Tamar Sabo   +8 more
doaj   +1 more source

Folding-competent and folding-defective forms of Ricin A chain have different fates following retrotranslocation from the endoplasmic reticulum [PDF]

, 2010
We report that a toxic polypeptide retaining the potential to refold upon dislocation from the endoplasmic reticulum (ER) to the cytosol (ricin A chain; RTA) and a misfolded version that cannot (termed RTAΔ), follow ER-associated degradation (ERAD ...
Alcock F., Allen S., Allen S. C., Argent R. H., Arndt V., Bar-Nun S., Barlowe C., Bazirgan O. A., Bellisola G., Biederer T., Bordallo J., Caldwell S. R., Carroll S. M., Carvalho P., Chaddock J. A., Christianson J. C., Christopher P. Guise, Deeks E. D., Denic V., Di Cola A., Duden R., Elkabetz Y., Endo Y., Gaber R. F., Gauss R., Ghislain M., Gietz R. D., Gillece P., Graham Ladds, Graham T. R., Haynes C. M., Hazes B., Heiligenstein S., Heinemeyer W., Hitt R., J. Michael Lord, Jarosch E., Jarosch E., Kaiser C. A., Kawaguchi S., Kim I., Kim Y., Knop M., Kohler A., Lipson C., Lord J. M., Lynne M. Roberts, Manfred J. Schmitt, Marshall R. S., Mayerhofer P. U., Medicherla B., Metzger M. B., Meusser B., Nakatsukasa K., Nishikawa S. I., Rabinovich E., Robert A. Spooner, Rodighiero C., Rouiller I., Rubin D. M., Sharma N., Shuyu Li, Sikorski R. S., Simpson J. C., Simpson J. C., Spear E. D., Spooner R. A., Spooner R. A., Spooner R. A., Springer S., Stuart C. H. Allen, Taxis C., Thomas Sommer, Tina Schnöder, Vashist S., Vashist S., Vogel J. P., Wesche J., Wilson J. D., Xia Z., Ye Y., Ye Y.   +81 more
core   +2 more sources

Fungal Infections in Pediatric Patients With Hematologic Malignancies and Stem Cell Transplantation: Impact on the Upper and Lower Respiratory Systems

Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 2026, Issue 1, 2026.
Invasive fungal infections (IFIs) are a leading cause of morbidity and mortality in children with hematological malignancies as well as those undergoing hematopoietic stem cell transplantation (HSCT). Extreme immunological dysregulation secondary to severe neutropenia, T‐cell lymphopenia, graft‐versus‐host disease (GVHD), intensive chemotherapy ...
Matin Pourghasem, Seyed Ahmad Tabatabaii, Seyedeh Zalfa Modarresi, Abdolhamid Jafari Nodoushan, Nafise Fadavi, Maedeh Soflaee, Ali Hosseini Vajari, Fatemeh Khazaii, Babak Shahhosseini, Korosh Fakhimi Derakhshan, Saeid Sadat Mansouri, Satabdi Datta Choudhury   +11 more
wiley   +1 more source