Results 81 to 90 of about 10,488 (210)

Investigating diversity and similarity between CBM13 modules and ricin-B lectin domains using sequence similarity networks

BMC Genomics
Background The CBM13 family comprises carbohydrate-binding modules that occur mainly in enzymes and in several ricin-B lectins. The ricin-B lectin domain resembles the CBM13 module to a large extent.
Tibo De Coninck, Garry P. Gippert, Bernard Henrissat, Tom Desmet, Els J.M. Van Damme   +4 more
doaj   +1 more source

Antibody/doxycycline combined therapy for pulmonary ricinosis: Attenuation of inflammation improves survival of ricin-intoxicated mice

Toxicology Reports, 2014
Ricin, a highly toxic plant-derived toxin, is considered a potential weapon in biological warfare due to its high availability and ease of preparation. Pulmonary exposure to ricin results in the generation of an acute edematous inflammation followed by ...
Yoav Gal, Ohad Mazor, Ron Alcalay, Nehama Seliger, Moshe Aftalion, Anita Sapoznikov, Reut Falach, Chanoch Kronman, Tamar Sabo   +8 more
doaj   +1 more source

Chromosome‐level genome assembly of the photobiont microalga Trebouxia sp. ‘A48’ from the lichen Xanthoria parietina

New Phytologist, Volume 249, Issue 2, Page 1036-1052, January 2026.
Summary Lichens are symbiotic assemblies consisting of multiple organisms, chiefly a fungus and a photosynthetic microorganism, or photobiont. Among diverse photobionts, the most prevalent is the chlorophyte alga Trebouxia. We produced a chromosome‐level assembly of Trebouxia sp. ‘A48’, a photobiont of Xanthoria parietina. The genome was assembled into
Gulnara Tagirdzhanova, Jasper Raistrick, Nicholas J. Talbot   +2 more
wiley   +1 more source

A Novel Zak Knockout Mouse with a Defective Ribotoxic Stress Response

Toxins, 2016
Ricin activates the proinflammatory ribotoxic stress response through the mitogen activated protein 3 kinase (MAP3K) ZAK, resulting in activation of mitogen activated protein kinases (MAPKs) p38 and JNK1/2.
Dakshina M. Jandhyala, John Wong, Nicholas J. Mantis, Bruce E. Magun, John M. Leong, Cheleste M. Thorpe   +5 more
doaj   +1 more source

Recommended Mass Spectrometry-Based Strategies to Identify Ricin-Containing Samples

Toxins, 2015
Ricin is a protein toxin produced by the castor bean plant (Ricinus communis) together with a related protein known as R. communis agglutinin (RCA120). Mass spectrometric (MS) assays have the capacity to unambiguously identify ricin and to detect ricin’s
Suzanne R. Kalb, David M. Schieltz, François Becher, Crister Astot, Sten-Åke Fredriksson, John R. Barr   +5 more
doaj   +1 more source

Fungal Infections in Pediatric Patients With Hematologic Malignancies and Stem Cell Transplantation: Impact on the Upper and Lower Respiratory Systems

Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 2026, Issue 1, 2026.
Invasive fungal infections (IFIs) are a leading cause of morbidity and mortality in children with hematological malignancies as well as those undergoing hematopoietic stem cell transplantation (HSCT). Extreme immunological dysregulation secondary to severe neutropenia, T‐cell lymphopenia, graft‐versus‐host disease (GVHD), intensive chemotherapy ...
Matin Pourghasem, Seyed Ahmad Tabatabaii, Seyedeh Zalfa Modarresi, Abdolhamid Jafari Nodoushan, Nafise Fadavi, Maedeh Soflaee, Ali Hosseini Vajari, Fatemeh Khazaii, Babak Shahhosseini, Korosh Fakhimi Derakhshan, Saeid Sadat Mansouri, Satabdi Datta Choudhury   +11 more
wiley   +1 more source

Isolation of a human-like antibody fragment (scFv) that neutralizes ricin biological activity

BMC Biotechnology, 2009
Background Ricin is a lethal toxin that inhibits protein synthesis. It is easily extracted from a ubiquitously grown plant, Ricinus communis, and thus readily available for use as a bioweapon (BW). Anti-ricin antibodies provide the only known therapeutic
Thullier Philippe, Dübel Stefan, Lefranc Marie-Paule, Hust Michael, Hale Martha, Pelat Thibaut   +5 more
doaj   +1 more source

Medical Countermeasures against Ricin Intoxication

, 2023
Ricin toxin is a disulfide-linked glycoprotein (AB toxin) comprising one enzymatic A chain (RTA) and one cell-binding B chain (RTB) contained in the castor bean, a Ricinus species.
Christine Rasetti-Escargueil, Arnaud Avril   +1 more
core   +1 more source

Reductive activation of ricin and ricin A-chain immunotoxins by protein disulfide isomerase and thioredoxin reductase.

, 2004
Intracellular activation of ricin and of the ricin A-chain (RTA) immunotoxins requires reduction of their intersubunit disulfide(s). This crucial event is likely to be catalyzed by disulfide oxidoreductases and precedes dislocation of the toxic subunit ...
Bellisola, Guiseppe, R. Ippoliti, TRIDENTE, Giuseppe, COLOMBATTI, Marco, S. Soldà, G. Menestrina, Udali, Silvia, Menestrina, Gianfranco, Tomazzolli, Rossella, Rosén, Anders,, A. Rosén, Ippoliti, Rodolfo, FRACASSO, Giulio, R. Tomazzolli, BELLISOLA, GIUSEPPE, Soldà, Silvia   +15 more
core   +2 more sources

Ricin binds to tubules of kidneys in ricin-intoxicated mice.

, 2013
IF was used to detect ricin in the kidneys from a ricin-intoxicated mouse (A) and a PBS control mouse (B). Ricin was detected with a primary rabbit polyclonal anti-RTA and goat anti-rabbit Ig-AlexaFluor® 488 as the secondary antibody.
Alyssa D. Flora (434164), Louise D. Teel (434165), Angela R. Melton-Celsa (434167), Mark A. Smith (21079), Alison D. O’Brien (434168), James F. Sinclair (434166)   +5 more
core   +1 more source