Results 81 to 90 of about 11,668 (212)

Structure based design of a ricin antidote [PDF]

, 2013
textRicin is a potent cytotoxin easily purified in large quantities. It presents a significant public health concern due to its potential use as a bioterrorism agent. For this reason, extensive efforts have been underway to develop antidotes against this
Jasheway, Karl Richard
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Ricinus Communis: Nutritional Importance, Health Benefits, and Industrial Applications

eFood, Volume 7, Issue 1, February 2026.
The current paper summarizes the nutritional composition, phytochemistry, health benefits, safety studies, and applications of castor beans and their oil. Moreover, the diverse bioactive compounds, including saponins, emodins, terpenoids, anthraquinones, flavonoids, steroids, and alkaloids, exhibit therapeutic properties such as antioxidant, anticancer,
Hassan Raza, Muhammad Tauseef Sultan, Asad Abbas, Aimen Mazhar, Ahmad Mujtaba Noman, Muhammad Imran, Muzzamal Hussain, Ehab M. Mostafa, Ahmed H. El‐Ghorab, Mohammed M. Ghoneim, Samy Selim, Mohamed A. Abdelgawad, Anjuman Gul Memon, Entessar Al Jbawi   +13 more
wiley   +1 more source

Synthesis and optimization of a library of small molecule inhibitors of ricin toxin A [PDF]

, 2013
textRicin is a potent cyctotoxin with no known antidote. Chapter 1 provides background and context for this thesis, which is primarily focused on probing the active site of Ricin toxin A (RTA). Relevant information about Ricin, its use, method of action,
Pruet, Jeffrey Michael
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Acute Toxicity and Genotoxicity of cMoL, a Lectin From Moringa oleifera Seeds With Antifungal Activity Against Cryptococcus Strains

Journal of Applied Toxicology, Volume 46, Issue 2, Page 682-696, February 2026.
ABSTRACT Coagulant Moringa oleifera lectin (cMoL) is one of the compounds involved in the application of M. oleifera seeds for traditional water treatment methods. The present study highlights the new biotechnological potential of cMoL lectin as an antifungal agent against Cryptococcus neoformans B3501 and H99 and Cryptococcus gattii R265 strains ...
Matheus Cavalcanti de Barros, Sávia Soraia Santana da Silva, Eduarda Pinto Gagliano, Alícia Natalie Silva dos Santos, Leydianne Leite de Siqueira Patriota, Gustavo Ramos Salles Ferreira, Pollyanna Michelle da Silva, Simone da Paz Leôncio Alves, Julliano Matheus de Lima Maux, Jacinto da Costa Silva Neto, Fernanda Rafaelly Nascimento de Santana, Fabiana Aparecida Cavalcante Silva, Marilene Henning Vainstein, Luana Cassandra Breitenbach Barroso Coelho, Thâmarah de Albuquerque Lima, Thiago Henrique Napoleão, Patrícia Maria Guedes Paiva   +16 more
wiley   +1 more source

Isolation of a human-like antibody fragment (scFv) that neutralizes ricin biological activity

BMC Biotechnology, 2009
Background Ricin is a lethal toxin that inhibits protein synthesis. It is easily extracted from a ubiquitously grown plant, Ricinus communis, and thus readily available for use as a bioweapon (BW). Anti-ricin antibodies provide the only known therapeutic
Thullier Philippe, Dübel Stefan, Lefranc Marie-Paule, Hust Michael, Hale Martha, Pelat Thibaut   +5 more
doaj   +1 more source

Ricin [PDF]

, 2004
Ricin is a powerful protein toxin found in the castor plant, Ricinus communis. Ricin is present in all parts of the plant but is particularly concentrated in the seeds. The toxin could be used as a biological weapon.

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Ricin binds to tubules of kidneys in ricin-intoxicated mice.

, 2013
IF was used to detect ricin in the kidneys from a ricin-intoxicated mouse (A) and a PBS control mouse (B). Ricin was detected with a primary rabbit polyclonal anti-RTA and goat anti-rabbit Ig-AlexaFluor® 488 as the secondary antibody.
Alyssa D. Flora (434164), Louise D. Teel (434165), Angela R. Melton-Celsa (434167), Mark A. Smith (21079), Alison D. O’Brien (434168), James F. Sinclair (434166)   +5 more
core   +1 more source

Ricin Toxin Activates the NALP3 Inflammasome

Toxins, 2010
Ricin exhibits well characterized ribotoxic actions that lead to the inhibition of protein synthesis and the phosphorylation of stress activated protein kinases (SAPKs).
Meghan Lindauer, John Wong, Bruce Magun
doaj   +1 more source

A Novel Zak Knockout Mouse with a Defective Ribotoxic Stress Response

Toxins, 2016
Ricin activates the proinflammatory ribotoxic stress response through the mitogen activated protein 3 kinase (MAP3K) ZAK, resulting in activation of mitogen activated protein kinases (MAPKs) p38 and JNK1/2.
Dakshina M. Jandhyala, John Wong, Nicholas J. Mantis, Bruce E. Magun, John M. Leong, Cheleste M. Thorpe   +5 more
doaj   +1 more source

Questions and answers about ricin [PDF]

Ricin is a poison found naturally in castor beans. If castor beans are chewed and swallowed, the released ricin can cause injury. Ricin can be made from the waste material left over from processing castor beans.

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