Results 91 to 100 of about 11,668 (212)
Serum toxicokinetics of ricin.
, 2013 A. Concentrations of ricin in mouse sera over 480 min post -intoxication. Ricin content was determined by IPCR. B. Concentrations of ricin in mouse sera from 2 to 30 min post-intoxication illustrating early and rapid sequestration of ricin with a t1/2α ...
Xiaohua He (361530) +4 more
core +1 more source
Medical Countermeasures against Ricin Intoxication
, 2023 Ricin toxin is a disulfide-linked glycoprotein (AB toxin) comprising one enzymatic A chain (RTA) and one cell-binding B chain (RTB) contained in the castor bean, a Ricinus species.
Christine Rasetti-Escargueil +1 more
core +1 more source
, 2004 Intracellular activation of ricin and of the ricin A-chain (RTA) immunotoxins requires reduction of their intersubunit disulfide(s). This crucial event is likely to be catalyzed by disulfide oxidoreductases and precedes dislocation of the toxic subunit ...
Bellisola, Guiseppe +15 more
core +2 more sources
Effects of ricin on primary pulmonary alveolar macrophages
Journal of International Medical Research, 2019 Objective We systematically investigated the cytotoxic effects of ricin in primary pulmonary alveolar macrophages (PAMs). Methods Primary PAMs were isolated from BALB/c mice.
Zhendong Guo +11 more
doaj +1 more source
Recommended Mass Spectrometry-Based Strategies to Identify Ricin-Containing Samples
Toxins, 2015 Ricin is a protein toxin produced by the castor bean plant (Ricinus communis) together with a related protein known as R. communis agglutinin (RCA120). Mass spectrometric (MS) assays have the capacity to unambiguously identify ricin and to detect ricin’s
Suzanne R. Kalb +5 more
doaj +1 more source
The cytosolic fate of ricin A chain in target cells [PDF]
Ricin is a heterodimeric, toxic plant protein. It is able to deliver its catalytic A chain (RTA) into the cytosol of target cells. RTA crosses the endoplasmic reticulum (ER) membrane into the cytosol, masquerading as a substrate of ER-associated ...
Hart, Philip John
core
Inhibitors of the Cellular Trafficking of Ricin
Toxins, 2012 Throughout the last decade, efforts to identify and develop effective inhibitors of the ricin toxin have focused on targeting its N-glycosidase activity.
Daniel Gillet +3 more
doaj +1 more source
Toxins, 2017 Ricin, a highly toxic plant-derived toxin, is considered a potential weapon in biowarfare and bioterrorism due to its pronounced toxicity, high availability, and ease of preparation.
Yoav Gal +6 more
doaj +1 more source
Exploiting the retrograde transport of disarmed toxins for the delivery of exogenous antigens into MHC class 1 presentation pathway [PDF]
The targeting of exogenous antigen into the MHC class 1-restricted presentation pathway is required for the induction of cytotoxic T lymphocytes (CTL) which have been shown to be an important component of the protective response to intracellular ...
Noakes, Karen
core